(...) Recent studies, some of them conducted in our laboratory, have revealed that pairing process does not participate in human aneuploidy etiology. However, implication of defective recombination in aneuploidy origin is clear. Similarly, recombination may influence segregation of homologue chromosomes in the first meiotic division. Moreover, epidemiologic studies have demonstrated maternal age implication in the production of unbalanced oocytes, most likely due to the presence of a defective meiotically specific cohesin. Thus, in this grant we want to study the recombinational process and chromosome segregation during the human female meiosis, as well as the mechanisms that control their evolution applyng immunofluorescent and in situ hybridization techniques on spread and 3D-structure preserved human oocytes in order to find the possible causes that explain the high difference existing in parental aneuploidy origin in human.
|Effective start/end date||1/10/06 → 30/09/09|