Els anells {Pt\sub 2\nosub S\sub 2\nosub } com metal·lolligands i com unitats bàsiques en estructures macromoleculars. Química bioinorgànica de tiolats metàl·lics: comportament \i in vivo\i0 de metal·

Project Details


The main objective of this projects aims at opening new perspectives in the current research areas of this group and it is based on the results obtained in the present project (PB97-0216) and on the indications withdrawn from the literature. Thus, the study of the metal complexes with sulphur containing ligands will focus on the analysis, under an experimental and theoretical point of view, of the influence of the nature of the terminal phosphine in the electronic features, and thus in the stability and reactivity (Lewis acid-base character and redox behaviour) of the central {Pt\sub 2\nosub S\sub 2\nosub} core in complexes of general formula [(P\sub O\nosub P)Pt(\mu-S)\sub 2\nosub Pt(P\sub O\nosub P)].Additionally, the previous complexes will be used as building blocks in the synthesis of macromolecular structures of formula [(Pt\sub 2\nosub S\sub 2\nosub )\sub m\nosub {L\sub 2\nosub Pt(\mu-S)\sub 2\nosub PtL\sub 2\nosub }\sub n\nosub ] cemented by {Pt\sub 2\nosub S\sub 2\nosub } rings. On the other hand, thioamide or iminothiol ligands will be assayed as an alternative to prevent formation of the polymeric species often found in metal thiolates. In the field of bioinorganic chemistry, we aim at studying the specific functions of metallothioneins (MT), nowadays still a matter of debate. The high purity of the recombinant MT proteins facilitates determination of their \i in vivo\i0 bindingcapacity towards essential metal ions. Thus, by comparison with the corresponding \i in vitro\i0 results, it will be possible to establish the Zn-or Cu-thionein nature of the recombinant protein. A phylogenetic analysisi of these data will allow us to propose a new classification of MT, more functional than the actual one. Furthemore, the study of the antioxidant activity of Zn-M, Cu-Mt and Zn, Cu-MT species from a wide variety of organisms will be essential in order to corroborate the adequacy of the proposed classification with the functionality of MT
Effective start/end date28/12/0127/12/04


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