The Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood disorder. The adolescent with ADHD is at high risk for academic failure, low self-esteem, poor peer relations, parental conflict, delinquency, and substance abuse. On the other hand, it is now recognized that ADHD often persists in the adulthood and it is associated, during this period, with disorders such as antisocial behaviour, substances abuse and mood disorders. Due to the high impact on our society, we think that it is necessary to have some instrument, an animal model in this case, in order to study the disorder indeep. In all research areas the main aim is to find or build models that could be used to summarize and simplify the understanding of a disorder. Ideally, an animal model should be similar to the disorder in terms of aetiology, biochemistry, symptomatology and treatment. The current ADHD animal models are based on the face validity. However, most of them only prove this validity partially. On the other hand, research in perinatal hypothyroidism suggest that this could be a good animal model for ADHD. The main aim of this study is the characterization of perinatal hypothyroidism as an animal model of ADHD by studying the following aspects: a) Face validity: the animals have to mimic the fundamental of the behaviour deficits of ADHD. b) Construct validity: the animal model has to confirm aspects as the current therapy for ADHD, i.e. metilphenidate. This treatment should show effectiveness reversing the animal's behaviour deficits or alterations. c) Predictive validity: it is possible to predict some valuable aspects not still taken into account in actual clinic studies, like some physiological aspects related to the neurobiology of ADHD.To achieve our goals we propose two different experiments. Experiment I: we will analyze if perinatal hypothyroid rats show behavioural alterations homologues to human symptoms, during childhood and adulthood periods(...)
|Effective start/end date||1/12/07 → 30/11/10|
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