In a previous study we showed that participationin clean-up activities of the Prestige ail spill resulted in a long-term increased prevalence of respiratory symptoms, bronchial hyperresponsiveness, increase of 8-isoprostane and interleukin-4 exhaled breath condensate, as well as an increase of chromosomal instability in exposed fishermen and shellfish farmers from Galicia. \b Hypotheses:\b0 Recurrent inhalatory exposure to volatile hydrocarbons fromm the oil of the tanker Prestige produced persistent oxidative stress, airways inflammation, bronchial hyperresponsiveness and respiratory symptoms. These compounds also induced the appearance or not complete repairof chromosomal lesions and alterations that, if persistent, might predispose to the development of cancer. \b Objectives:\b0 To evaluate the persistency of respiratory and genotoxic effects through the re-evaluation of clinical, biological and functional alterations five years after exposure to the clean up activities of the Prestige oil spill. \b Methodology\b0 : Prospective follow-up study of galician fishermen, including both exposed and non-exposed to the clean-up activities of the Prestige oil spill.678 coastal fishermen and shellfish farmers associated with 26 Galician cooperatives, who participated in the second stage of the previous survey, will be contacted (501 exposed and 177 non-exposed). Information on respiratory symptoms will be obtained by using telephone interviews. Spirometric lung function testing, methacoline challenge testing, determination of makersof inflammation and oxidative stress, as well as chromosomal instability in peripheral blood lymphocytes (analysis of chromosomal fragility and molecular cytogenetical techniques) will be performed in the sub sample of 317 lifetime non-smoking participants (230 exposed and 87 non-exposed).
|Effective start/end date||16/10/07 → 30/03/11|
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