Transforming growth factor beta (TGF-"beta") is a polypeptidic growth factor which acts as a potent growth inhibitor and a differenciation promoter in several types of cells. One of the most important phenotipic effects of TGF-"beta" is induction of several components of the extracellular matrix (ECM), amongst which are the proteoglycans (PGs). On the other hand, it is well known that the ECM can modulate cell proliferation, adhesion, migration and shape, as well as complex processes as tissue morphogenesis and embryogenesis. The aim of this project is the study of the relationship between TGF-"beta" effects on cell proliferation and the changes in ECM structure, regarding specially to the PGs. The working hypothesis is that TGF-"beta" effects can be mediated, at least partially, by the ECM. The particular goals of the project are a) study of the mechanism of TGF-"beta" action on PG meta
|Effective start/end date||2/08/91 → 2/08/94|
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