Desenvolupament de noves estratègies en síntesi estereoselectiva de mol.lècules bioactives de compostos carbonílics \alpha, \beta-insaturats

The aim of this project is the stereoselective total synthesis of natural products having any interesting biological activity or their analogues. Starting materials are \alpha, \beta-unsaturated carbonyl compounds, particularly lactones, esters and p-benzoquinone acetals. For the asymmetric induction we use materials from the chiral pool and C\sub 2\nosub symmetric diols as auxiliaries. Key reactions are mainly 1, 3-dipolar and [2+2] photochemical cycloadditions. Some of the strategies relay on bidirectional synthesis. Target compounds are the Securinega and Stemona family alkaloids, several polyfunctionalised cyclohexanes with pharmaogical activity, cyclobutanic pheromones and cyclobutanic nucleosides