Desenvolupament de noves estratègies en síntesi estereoselectiva de mol.lècules bioactives de compostos carbonílics \alpha, \beta-insaturats

  • Font Cierco, Josep (Principal Investigator)
  • Ballbé Mohedano, Marta (Scholar)
  • Blanco Merinero, Pilar (Scholar)
  • Busque Sanchez, Felix (Scholar)
  • Canto Vallverdu, Maria (Scholar)
  • Casas Arce, Eva (Scholar)
  • Garcia Garcia, Elena (Scholar)
  • Peris Franquet, Eduard (Scholar)
  • Racamonde Villanueva, Marta (Scholar)
  • Elias Rius, Laia (Researcher on contract)
  • Marjanet Artigas, Georgina (Researcher on contract)
  • Sanfeliu Sabater, Elena (Researcher on contract)
  • Alibes Arques, Ramon (Investigator)
  • Figueredo Galimany, Marta (Investigator)
  • March Centelles, Pere de (Investigator)

Project Details

Description

The aim of this project is the stereoselective total synthesis of natural products having any interesting biological activity or their analogues. Starting materials are \alpha, \beta-unsaturated carbonyl compounds, particularly lactones, esters and p-benzoquinone acetals. For the asymmetric induction we use materials from the chiral pool and C\sub 2\nosub symmetric diols as auxiliaries. Key reactions are mainly 1, 3-dipolar and [2+2] photochemical cycloadditions. Some of the strategies relay on bidirectional synthesis. Target compounds are the Securinega and Stemona family alkaloids, several polyfunctionalised cyclohexanes with pharmaogical activity, cyclobutanic pheromones and cyclobutanic nucleosides
StatusFinished
Effective start/end date28/12/0127/12/04

Funding

  • Ministerio de Ciencia y Tecnología: €317,935.40

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