Gastrin/CCK family peptides play a physiological role on the regulation of gastrointestinal motility. Nitric oxide (NO) has been recently described as a putative non-adrenergic-non-cholinergic inhibitory neurotransmitter of the enteric nervous system. We propose a multifocal approach to the CCK mechanism of action on the rat gastrointestinal tract, receptors and neural mediators implicated. Preliminary studies show that NO is involved in the mechanism of action of some gastrointestinal peptides. Thus, the study of the physiological role of NO as a regulator of the motility and its implication in the mechanism of action of CCK is an important aim of this project. The study will be undertaken by means of "in vivo" (electromyography of the stomach, small intestine and colon, gastricemptying and isolated intestinal segments) and "in vitro" techniques (organ bath, intracellular recordings in
|Effective start/end date||26/05/93 → 26/05/96|
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