Control de qualitat de la indústria farmacèutica per espec- troscopia en l'infraroig pròxim

The aim of this project is to develop the application of near infrared spectrosocpy (NIR) to the quality control in the pharmaceutical industry, through the direct analysis of raw materials, intermediate mixtures and final products. NIR diffuse reflectance spectra of the samples will be recorded by the conventional batch procedure and by using optical fibers. The precision and accuracy of the results obtained by both procedures will be compared and a sound validation of the developped methodologies perfomed. In order to decode all the analytical information contained by the spectra, chemometrics procedures will be used, and applied both to quantitative chemical analysis and to the estimation of some interesting physical parameters: particle size and mixture homogeneity. The modern multivariate techniques of calibration will be tested in order to obtain a correct calibration. It is projec