The hepatitis C virus (HCV) is the most common cause of chronic viral infection in Spain and the causative agent of the majority of cases of chronic liver disease and hepatocellular carcinoma. HCV is the first infectious agent identified by direct molecular cloning, after all conventional methods for its isolation had proven to be unsuccesfull. In fact, most of our knowledge about HCV has been generated from sequencing its entire genome and producing antegenic recombinant protein. This project is aimed at developing a simple technique for concentration of HCV particles in a small volume sample by immunoabsortion (which should simplify and enhance the sensitivity of current techniques for HCV-RNA detection) and optimizing several techniques for large scale concentration and purification of HCV particles in order to obtain final products containing a minimum of 10 sub10/ml HCV native parti
|Effective start/end date||10/11/92 → 31/12/94|
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