Study objective: To charcterize the molecular mechanisms leading to Retinosis Pigmentaria (RP) linked to rhodopsin. RP is the main and no curable cause of adult blindness. Design: Construction, cloning and expression of the identified individual mutations. Cellular classification of the cases. Production of the mutants classified as Type I and biochemical characterization of its functionallity. Duration of the study: 3 years. Patients: Rhodopsin-linked RP-diagnosed patients (RP multicentric action, presently operating).
|Effective start/end date||11/04/96 → 1/09/99|