The idea that changes in the electrical impedance of a biological (or other) system may be used as transductionprinciple for the development of sensors is not new. The large potential number of applications is also surprising, due to the easy application in direct or non-invasive measurement, and especially when the multidimensional features of the obtained signal are exploited, The above mentioned characteristic is responsible fpor the terminology used in the field: Electrochemical Impedance Spectroscopy (EIS) that displays resistive and properties of a medium versus different frequencies of applied AC voltage. However, the number of commercial devices and devices with industrial, environmental, food, medical or clinical applications in scare. The presented R+D project proposes the use of EIS for the development of biosensors, for its characterisation and for its more efficient optisation. It also aims to the use of the technique as the transduction principle for the construction of biosensors based on intergitated structures employing immobilised components such as microorganisms or DNA. Tentative applications are the multivariate determination using biosensor arrays, a specific biosensor (surfactants), a non specific sensor (toxicity) and the introduction of gene sensors. The final aim is the integration in a single microfabricated biosystem piece perfoming detection and amplification for DNA analysis
|Effective start/end date||28/12/01 → 27/12/04|
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