Aproximació biotecnològica a les metal.loproteases

  • Aviles Puigvert, Francesc Xavier (Principal Investigator)
  • Companys García, Verónica (Scholar)
  • Gomez Ortiz, María de la O (Scholar)
  • Lorenzo Rivera, Julia (Scholar)
  • Marino-Buslje, Cristina (Scholar)
  • Reverter Cendros, David (Scholar)
  • Xavier Daura Ribera (Scholar)
  • Canals Suris, Francesc (Investigator)
  • Jorba Barguño, Xavier (Investigator)
  • Oliva Miguel, Baldomero (Investigator)
  • Vendrell Roca, Josep (Investigator)

Project Details

Description

An overall research on metalloproteases -carboxypeptidases and endoproteases-, on their precursors and on their specific inhibitors, is proposed with different goals of biotechnological interest: redesign to improve their specificity, thermostability and renaturability, new procedure for their massive production by heterologous expression and quick purification, development and use of advanced biocomputerized procedures for their rational design and the simulation of their properties, design of specific inhibitors of potential pharmacological application, and use of these proteases and precursors as markers of pancreatic pathologies (mainly cancer). The research will be particularly focused on new carboxypeptidases and mutants obtained by genetic engineering procedures: carboxypeptidases A2 and B, mast cell carboxypeptidase, mitocondrial carboxypeptidase and carboxypeptidase-Taq. By X-ra
StatusFinished
Effective start/end date1/07/951/07/98

Funding

  • Comisión Interministerial de Ciencia y Tecnología (CICYT)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.