Diabetes mellitus is the most common metabolic disease in humans. In spite of a immense investment of resources, a clear understanding of the basic pathogenic mechanisms of diabetes has not yet emerged. Conventional approaches do not provide further insights in the comprehension of this process. Gene transfer into animals of key genes in the regulation of the metabolic pathways involved in the development of the diabetic process will support the understanding of this group of pathologies and the establishment of new therapy protocols. In this project, we will generate and analyze transgenic animals to be used as models for the study of liver and pancreas contribution to diabetic alterations. At the same time, we will obtain a chimeric gene that will allow the expression of human insulin in a regulated and fully processable way by extrapancreatic tissues. These studies in animal models represent the first and essential step to the establishment of a gene therapy protocol in humans
|Effective start/end date||1/01/94 → 1/01/97|
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