Transforming growth factors (TGFs) and growth factors are raising a big deal of interest because their role as regulators of cell proliferation and differentiation. Amongst them, TGF-b stands out because of its peculiar characteristics. Several of these factors, specially TGF-b, can induce important changes in the extracellular matrix, a structure involved in the control of basic phenomena as morphogenesis and carcinogenesis. One of the main components are the proteoglycans (PGs), which are induced by TGF-b. The working hypothesis of this project is that the effects on the extra cellular matrix and the effects on proliferation and differentiation are related. The main goals are to study: 1) the effects of TGF-b and other growth factors on the production and processing of PGs in normal cells, using specific tools as antibodies and cDNA probes, and 2) the effects of TGF-b on the proliferation and differentiation of cancer cells, using the human melanoma; this is an interesting model because we have several cell lines in various states of differentiation and because they express a specific PG as a differentiation marker
|Effective start/end date||1/04/90 → 31/03/91|
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