Agents clau en la resposta immune primerenca en peixos

  • Tort Bardolet, Lluis (Principal Investigator)
  • Acerate Rodríguez, Laura (Scholar)
  • Adriana Hernández Sierra (Scholar)
  • Liarte Quesada, Cristina (Scholar)
  • Mackenzie , Simon Anthony (Researcher on contract)
  • Padros Bover, Francesc (Researcher on contract)
  • Crespo Giménez, Sílvia (Investigator)
  • Ribas Cabezas, Laia (Investigator)

Project Details

Description

Previous studies of the research group have focused on the non-specific immune response in fish, more varied and powerful than the specific, and the dynamics of such responses after stress episodes and or infection. In the previous project (AGL) the role of the complement system and its activation mechanisms were determined. In the present proposal, the role of other relevant processes in the early immune response of fish, in particular, the role of certain cytokines (TFN) will be firstly studied in relation with the activation of myeloid cells. Secondly, the dynamics of myeloid cells will be studied in relation to maturation and cell trafficking to the tissues, where immune action is carried out. Thus, the integration of the role of these key factors (complement, cytokines and cell trafficking) with a functional approach, will enable to further elucidate the coordination of non-specific immune activation systems. Two species will be used, Rainbow trout (freshwater), and mostly sea bream (marine). Experimental models both in vitro (cell cultures) and in vivo will be used. For in vivo experiments, different experiments with stress (acute and mainly chronic) will be performed, as the group has a wide experience in the field, as well as experimental bacterial infection. In the case of sea ream a treatment with a ciliated parasite (Microcotile) will be also performed as it is one of the most widely distributed pathogens for sea bream in the Mediterranean, which the group has already investigated. The development of the present project will improve the understanding of the mechanisms of the immune systems in fish and, therefore, allow to design strategies for the prevention of immune suppression, pathogen entry and disease occurrence

StatusFinished
Effective start/end date1/12/0330/11/06

Funding

  • Ministerio de Ciencia y Tecnología: €7,400.00

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