Intracellular calcium plays a central role as a second messenger in the control of a wide range of cellular functions. In the central nervous system it is well known that entry of calcium through voltage-gated membrane channels is necessary for the stimulus-secretion coupling and that calcium is the most important regulator of this process. Only the L-type of voltage sensitive calcium channels are sensitive to dihydropyridines. Although there are accumulating evidences that these substances can modulate several functions of the central nervous system, the actions of dihhydropyridines in this tissue are still controversial. Because of this, the aim of the present project is to study the effects of several dihydropyrines on the release of acetilcholine, dopamine and noradrenaline in rat brain synaptosomes
|Effective start/end date||1/04/90 → 31/03/91|
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