A Cluster for tuberculosis vaccine developement - TB VACCINE CLUSTER

Project Details


The overall objective of the Cluster is to establish a framework for preclinical development of novel tuberculosis vaccine candidates. We aim to identify optimal strategies for generation of vaccine candidates by comparing innovative approaches based on identification of novel protein antigens, characterisation of non-protein antigens that elicit T cell responses in man, and construction of live attenuated strains of mycobacteria. New vaccines will be compared alone or in combination in standardised experimental challenge models to identify candidates superior to the existing BCG vaccine. In parallel, the immunological mechanisms underlying vaccine-induced protection will be characterised in man and in experimental models. This information will be used to develop immunological tests for initial clinical asse ssment of new vaccines. Integration of these activites, with the participation of the top academic and industrial researchers in Europe (Aventis Pasteur, SmithKline Beecham and the Statens Serum Institut), is essential for completion of the final goal of bringing one or more new vaccines to a stage suitable for clinical trials.
Effective start/end date1/02/0031/12/03

Collaborative partners

  • Institut Pasteur (lead)
  • The Chancellor, Masters And Scholars of the University Of Oxford
  • Leibniz University Hannover
  • Biomedical Primate Research Centre
  • Centre National de la Recherche Scientifique (CNRS)
  • German Research Centre for Biotechnology (Gesellschaft für Biotechnologische Forschung)
  • IRCCS Institute for Infectious Diseases Lazzaro Spallanzani
  • French Institute of Health and Medical Research
  • Institut Pasteur de Lille
  • London School of Hygiene & Tropical Medicine
  • Ministry of Agriculture, Fisheries and Food -GB-
  • Max Planck Society
  • Microbiological Research Authority
  • Medical Research Council (MRC)
  • Ministere aux Affaires Sociales a la Sante Publique et a l'Environnement
  • National Biological Standards Board
  • Pasteur Mérieux Sérums and Vaccins
  • Queen's University of Belfast
  • Leiden University (LEI)
  • SmithKline Beecham Biologicals s.a.
  • Statens Serum Institut
  • Swedish Institute for Infectius Disease Control
  • Netherlands Organization for Applied Scientific Research
  • University of Basel
  • University of Bergen
  • University of Erlangen–Nuremberg (FAU)
  • University of Surrey
  • University of Zaragoza (UNIZAR)
  • Universitat Autònoma de Barcelona (UAB)


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