Ús de trasplantaments de glia envoltant del bulb olfactori per promoure la regeneració als sistemes nerviosos perifèric i central lesionats

  • Cuadras Mas, Jordi (Principal Investigator)
  • Buti Sole, Miquel (Investigator)
  • Calvet Marquez, Santiago (Investigator)
  • Navarro Acebes, Xavier (Investigator)
  • Nieto Sampedro, Manuel (Investigator)
  • Verdú Navarro, Enrique (Investigator)
  • Viñeta, Joaquin Fores (Investigator)

Project Details

Description

Study objective: to test whether the ability of ensheathing glia to promote the regeneration of some sensory fibers, can be generalized. Check that the regenerated fibers do engage in functional synaptic relations. Design: a pluridisciplinar study, using techniques of cell culture, microscopy (optical and electron), electrophysiology and behavior. Setting: repair of damaged nerve fibers in chosen loci of the adult nervous system. Subjects: mammals of species ranging from rodent to pig. Interventions: well-defined surgical lesions (sciatic and pelvic nerve transection; dorsal root transection; internuclear neuron axotomy in the external ocular motor nucleus). Measurements: yield, in the culture and purification of ensheathing glia. Use of these glial cells to enhance the repair (anatomical, electrophysiological and behavioral) of damaged neural circuits.
StatusFinished
Effective start/end date1/01/9531/12/97

Funding

  • Fondo de Investigación Sanitaria: €45,075.91

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