Áreas de Salud Ambiental, Laboral y Reproductiva (CIBERESP)

Project Details

Description

1. Genotoxic/carcinogenic mechanisms of arsenic

This research field involves both in vitro and biomonitoring studies with exposed populations. The most interesting recent results can be summarized as:

a. In the human populations studied (Chile and Mexico), the exposed people (never mind if they are occupationally or environmentally exposed) present high levels of genetic damage.

b. We have found a new polymorphism of the AS3MT gene (Met287Thr) acting as an important modulator of the genetic risk. Individuals carrying such variant accumulate the metabolite MMA(III) that is the arsenic specie showing the highest genotoxic potentiality.

c. We have generated a wide set of in vitro tools to evaluate the carcinogenic potential of arsenic.

d. We have demonstrated for first time that oxidative damage plays an important role in both the genotoxicity and carcinogenicity of arsenic.



2. Risk factors in patients with thyroid pathologies

The most important goals reached in this research line can be summarized as follows:

a. We have found a region in chromosome 1p12 showing a strong association with thyroid cancer. In this region there is a new gene (WDR3) responsible of the observed association

b. We have found associations between different genes involved in the repair of DNA (OGG1, XRCC1, XRCC2 and XRCC3) and the metabolism of thyroid (TG) and the thyroid cancer.

c. In a wide study of all the genome (GWA), carried out with samples from four European populations we have found a strong association with the rs6759952 polymorphism of the DIRC3 gene.

d. Finally, in a collaborative study with Italian groups we have shown for first time that the thyroperoxidase gene (TPO) is involved in the risk of suffering thyroid cancer.



3. Risk factors in patients with kidney thyroid pathologies

The most important recent goals of this research line are as follows:

a. We have found that patients with chronic renal failure (CRF) present high levels of genetic damage at both primary and fixed level.

b. The CRF patients are characterized by genomic instability. This supposes that these patients are extremely sensitive to the environmental genotoxicants.

c. CRF patients present high mortality, but not specific causes have been found.

d. DNA oxidative damage and its inability to repair it is an important factor explaining why these patients show high levels of genetic damage.



4. Genotoxic mechanisms of nanomaterials.

This is a recent research line aiming to determine the risk that can suppose the presence of these new materials in our near environment.

The obtained results until now indicate that

a. Silver in its nanoparticulated form is able of induce genotoxic damage in vivo as we have demonstrate in Drosophila.

b. We have detected several nanomaterials such as titanium dioxide and zinc oxide modulate the genotoxic effects induced by UV light.

c. Long-term exposures to sub-toxic doses of cobalt nanoparticles induce cell transformation as well as other markers of tumoral processes.

d. Cerium nanoparticles pose antioxidant potential both in vivo and in vitro.

AcronymCIBERESP
StatusActive
Effective start/end date6/02/0931/12/30

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