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Rafael Blesa Gonzalez

    • Source: Scopus
    • Calculated based on no. of publications stored in Pure and citations from Scopus
    20062019

    Research activity per year

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    Search results

    • 2019

      Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse

      Alcolea, D., Pegueroles, J., Muñoz, L., Camacho, V., López-Mora, D., Fernández-León, A., Le Bastard, N., Huyck, E., Nadal, A., Olmedo, V., Sampedro, F., Montal, V., Vilaplana, E., Clarimón, J., Blesa, R., Fortea, J. & Lleó, A., 1 Sep 2019, In: Annals of Clinical and Translational Neurology. 6, p. 1815-1824

      Research output: Contribution to journalArticleResearch

      27 Citations (Scopus)
    • Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer’s disease cerebrospinal fluid*

      Lleó, A., Núñez-Llaves, R., Alcolea, D., Chiva, C., Balateu-Paños, D., Colom-Cadena, M., Gomez-Giro, G., Muñoz, L., Querol-Vilaseca, M., Pegueroles, J., Rami, L., Lladó, A., Molinuevo, J. L., Tainta, M., Clarimón, J., Spires-Jones, T., Blesa, R., Fortea, J., Martínez-Lage, P., Sánchez-Valle, R. & 3 others, Sabidó, E., Bayés, À. & Belbin, O., 1 Mar 2019, In: Molecular and Cellular Proteomics. 18, p. 546-560

      Research output: Contribution to journalArticleResearch

      48 Citations (Scopus)
    • Cortical microstructure in the behavioural variant of frontotemporal dementia: Looking beyond atrophy

      Illán-Gala, I., Montal, V., Borrego-Écija, S., Vilaplana, E., Pegueroles, J., Alcolea, D., Sánchez-Saudinós, B., Clarimón, J., Turón-Sans, J., Bargalló, N., González-Ortiz, S., Rosen, H. J., Gornoini, M. L., Miller, B. L., Lladó, A., Rojas-García, R., Blesa, R., Sánchez-Valle, R., Lleó, A. & Fortea, J., 1 Jan 2019, In: Brain. 142, p. 1121-1133

      Research output: Contribution to journalArticleResearch

      21 Citations (Scopus)
    • Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer’s disease

      Morenas-Rodríguez, E., Alcolea, D., Suárez-Calvet, M., Muñoz-Llahuna, L., Vilaplana, E., Sala, I., Subirana, A., Querol-Vilaseca, M., Carmona-Iragui, M., Illán-Gala, I., Ribosa-Nogué, R., Blesa, R., Haass, C., Fortea, J. & Lleó, A., 1 Dec 2019, In: Scientific Reports. 9, 7803.

      Research output: Contribution to journalArticleResearch

      10 Citations (Scopus)
    • Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD

      Alcolea, D., Irwin, D. J., Illán-Gala, I., Muñoz, L., Clarimón, J., McMillan, C. T., Fortea, J., Blesa, R., Lee, E. B., Trojanowski, J. Q., Grossman, M. & Lleo, A., 1 Feb 2019, In: Journal of Neurology, Neurosurgery and Psychiatry. 90, p. 180-186

      Research output: Contribution to journalArticleResearch

      13 Citations (Scopus)
    • Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

      Bonham, L. W., Steele, N. Z. R., Karch, C. M., Broce, I., Geier, E. G., Wen, N. L., Momeni, P., Hardy, J., Miller, Z. A., Gorno-Tempini, M. L., Hess, C. P., Lewis, P., Miller, B. L., Seeley, W. W., Manzoni, C., Desikan, R. S., Baranzini, S. E., Ferrari, R., Yokoyama, J. S., Hernandez, D. G. & 80 others, Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Landqvist Waldö, M., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G. Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Pastor, P., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Mead, S., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Cruts, M., Van Broeckhoven, C., Cappa, S. F., Leber, I. & Hannequin, D., 1 Dec 2019, In: Scientific Reports. 9, 10854.

      Research output: Contribution to journalArticleResearch

      5 Citations (Scopus)
    • Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

      Moreno-Grau, S., de Rojas, I., Hernández, I., Quintela, I., Montrreal, L., Alegret, M., Hernández-Olasagarre, B., Madrid, L., González-Perez, A., Maroñas, O., Rosende-Roca, M., Mauleón, A., Vargas, L., Lafuente, A., Abdelnour, C., Rodríguez-Gómez, O., Gil, S., Santos-Santos, M. Á., Espinosa, A., Ortega, G. & 79 others, Sanabria, Á., Pérez-Cordón, A., Cañabate, P., Moreno, M., Preckler, S., Ruiz, S., Aguilera, N., Pineda, J. A., Macías, J., Alarcón-Martín, E., Sotolongo-Grau, O., Abdelnour, C., Alarcon, E., Benaque, A., Boada, M., Buendia, M., Carracedo, A., Corbatón, A., Diego, S., Gailhajenet, A., García González, P., Guitart, M., Ibarria, M., Macias, J., Martín, E., Martínez, M. T., Marquié, M., Monté-Rubio, G., Orellana, A., Pancho, A., Pelejà, E., Real, L. M., Ruiz, A., Ruiz, S., Sáez, M. E., Sanabria, A., Serrano-Rios, M., Tárraga, L., Valero, S., Adarmes-Gómez, A. D., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Buiza-Rueda, D., Bullido, M. J., Burguera, J. A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M. J., Clarimón, J., Cruz-Gamero, J. M., de Pancorbo, M. M., del Ser, T., Diez-Fairen, M., Fortea, J., Franco, E., Frank-García, A., García-Alberca, J. M., Garcia Madrona, S., Garcia-Ribas, G., Gómez-Garre, P., Hevilla, S., Jesús, S., Espinosa, L., Lage, C., Legaz, A., Lleó, A., López de Munáin, A., López-García, S., Macias, D., Manzanares, S., Marín, M., Marín-Muñoz, J. & Marín, T., 1 Oct 2019, In: Alzheimer's and Dementia. 15, 10, p. 1333-1347 15 p.

      Research output: Contribution to journalArticleResearch

      31 Citations (Scopus)
    • Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

      Swarup, V., Hinz, F. I., Rexach, J. E., Noguchi, K. I., Toyoshiba, H., Oda, A., Hirai, K., Sarkar, A., Seyfried, N. T., Cheng, C., Haggarty, S. J., Ferrari, R., Rohrer, J. D., Ramasamy, A., Hardy, J., Hernandez, D. G., Nalls, M. A., Singleton, A. B., Kwok, J. B. J., Dobson-Stone, C. & 80 others, Brooks, W. S., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A., Cairns, N. J., Cruchaga, C., Binetti, G., Ghidoni, R., Benussi, L., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Waldö, M. L., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G. Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Jaros, E., Pietrini, P., Huey, E. D., Wassermann, E. M., Tierney, M. C., Baborie, A., Pastor, P., Ortega-Cubero, S., Razquin, C., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., George-Hyslop, P. S., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Mead, S., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., Pickering-Brown, S., Momeni, P., van der Zee, J., Cruts, M., Van Broeckhoven, C., Cappa, S. F., Leber, I., Brice, A., Hannequin, D. & Golfier, V., 1 Jan 2019, In: Nature Medicine. 25, p. 152-164

      Research output: Contribution to journalArticleResearch

      36 Citations (Scopus)
    • The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders

      Alcolea, D., Clarimón, J., Carmona-Iragui, M., Illán-Gala, I., Morenas-Rodríguez, E., Barroeta, I., Ribosa-Nogué, R., Sala, I., Sánchez-Saudinós, M. B., Videla, L., Subirana, A., Benejam, B., Valldeneu, S., Fernández, S., Estellés, T., Altuna, M., Santos-Santos, M., García-Losada, L., Bejanin, A., Pegueroles, J. & 21 others, Montal, V., Vilaplana, E., Belbin, O., Dols-Icardo, O., Sirisi, S., Querol-Vilaseca, M., Cervera-Carles, L., Muñoz, L., Núñez, R., Torres, S., Camacho, M. V., Carrió, I., Giménez, S., Delaby, C., Rojas-Garcia, R., Turon-Sans, J., Pagonabarraga, J., Jiménez, A., Blesa, R., Fortea, J. & Lleó, A., 1 Jan 2019, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 597-609

      Research output: Contribution to journalArticleResearch

      16 Citations (Scopus)
    • Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

      Powers, R. K., Culp-Hill, R., Ludwig, M. P., Smith, K. P., Waugh, K. A., Minter, R., Tuttle, K. D., Lewis, H. C., Rachubinski, A. L., Granrath, R. E., Carmona-Iragui, M., Wilkerson, R. B., Kahn, D. E., Joshi, M., Lleó, A., Blesa, R., Fortea, J., D’Alessandro, A., Costello, J. C., Sullivan, K. D. & 1 others, Espinosa, J. M., 1 Dec 2019, In: Nature Communications. 10, 4766.

      Research output: Contribution to journalArticleResearch

      27 Citations (Scopus)
    • Two year outcomes, cognitive and behavioral markers of decline in healthy, cognitively normal older persons with global deterioration scale stage 2 (Subjective cognitive decline with impairment)

      Reisberg, B., Torossian, C., Shulman, M. B., Monteiro, I., Boksay, I., Golomb, J., Benarous, F. G., Ulysse, A., Oo, T., Vedvyas, A., Rao, J. A., Marsh, K., Kluger, A., Sangha, J., Hassan, M., Alshalabi, M., Arain, F., Shaikh, N., Buj, M., Kenowsky, S. & 12 others, Masurkar, A. V., Rabin, L., Noroozian, M., Sanchez-Saudinos, M. B., Blesa, R., Auer, S., Zhang, Y., De Leon, M., Sadowski, M., Wisniewski, T., Gauthier, S. & Shao, Y., 1 Jan 2019, In: Journal of Alzheimer's Disease. 67, p. 685-705

      Research output: Contribution to journalArticleResearch

      4 Citations (Scopus)
    • 2018

      Analysis of known amyotrophic lateral sclerosis and frontotemporal dementia genes reveals a substantial genetic burden in patients manifesting both diseases not carrying the C9orf72 expansion mutation

      Dols-Icardo, O., García-Redondo, A., Rojas-García, R., Borrego-Hernández, D., Illán-Gala, I., Muñoz-Blanco, J. L., Rábano, A., Cervera-Carles, L., Juárez-Rufián, A., Spataro, N., De Luna, N., Galán, L., Cortes-Vicente, E., Fortea, J., Blesa, R., Grau-Rivera, O., Lleó, A., Esteban-Pérez, J., Gelpi, E. & Clarimón, J., 1 Feb 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89, 2, p. 162-168

      Research output: Contribution to journalArticleResearchpeer-review

      26 Citations (Scopus)
    • Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease

      Cantero, J. L., Atienza, M., Sanchez-Juan, P., Rodriguez-Rodriguez, E., Vazquez-Higuera, J. L., Pozueta, A., Gonzalez-Suarez, A., Vilaplana, E., Pegueroles, J., Montal, V., Blesa, R., Alcolea, D., Lleo, A. & Fortea, J., 1 Apr 2018, In: Neurobiology of Aging. 64, p. 58-67

      Research output: Contribution to journalArticleResearchpeer-review

      7 Citations (Scopus)
    • Challenges associated with biomarker-based classification systems for Alzheimer's disease

      Illán-Gala, I., Pegueroles, J., Montal, V., Vilaplana, E., Carmona-Iragui, M., Alcolea, D., Dickerson, B. C., Sánchez-Valle, R., de Leon, M. J., Blesa, R., Lleó, A. & Fortea, J., 1 Jan 2018, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 346-357

      Research output: Contribution to journalArticleResearchpeer-review

      22 Citations (Scopus)
    • Clinical Subtypes of Dementia with Lewy Bodies Based on the Initial Clinical Presentation

      Morenas-Rodríguez, E., Sala, I., Subirana, A., Pascual-Goñi, E., Sánchez-Saudinós, M. B., Alcolea, D., Illán-Gala, I., Carmona-Iragui, M., Ribosa-Nogué, R., Camacho, V., Blesa, R., Fortea, J. & Lleó, A., 1 Jan 2018, In: Journal of Alzheimer's Disease. 64, 2, p. 505-513

      Research output: Contribution to journalArticleResearchpeer-review

      6 Citations (Scopus)
    • Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort

      Verheijen, J., van der Zee, J., Gijselinck, I., Van den Bossche, T., Dillen, L., Heeman, B., Gómez-Tortosa, E., Lladó, A., Sanchez-Valle, R., Graff, C., Pastor, P., Pastor, M. A., Benussi, L., Ghidoni, R., Binetti, G., Clarimon, J., de Mendonça, A., Gelpi, E., Tsolaki, M., Diehl-Schmid, J. & 47 others, Nacmias, B., Almeida, M. R., Borroni, B., Matej, R., Ruiz, A., Engelborghs, S., Vandenberghe, R., De Deyn, P. P., Cruts, M., Van Broeckhoven, C., Sleegers, K., Goeman, J., Nuytten, D., Vandenbulcke, M., Santens, P., De Bleecker, J., Sieben, A., Dermaut, B., Versijpt, J., Michotte, A., Deryck, O., Bergmans, B., Willems, C., Ivanoiu, A., Salmon, E., Alexopoulos, P., Sorbi, S., Bessi, V., Bagnoli, S., Santana, I., Simões do Couto, F., Martins, M., Thonberg, H., Fratiglioni, L., Padovani, A., Rohan, Z., Razquin, C., Lorenzo, E., Iglesias, E., Seijo-Martínez, M., Rene, R., Gascon, J., Campdelacreu, J., Koutroumani, M., Lleó, A., Fortea, J. & Blesa, R., 1 Feb 2018, In: Neurobiology of Aging. 62, p. 245.e1-245.e7

      Research output: Contribution to journalArticleResearchpeer-review

      14 Citations (Scopus)
    • Cortical microstructural changes along the Alzheimer's disease continuum

      Montal, V., Vilaplana, E., Alcolea, D., Pegueroles, J., Pasternak, O., González-Ortiz, S., Clarimón, J., Carmona-Iragui, M., Illán-Gala, I., Morenas-Rodríguez, E., Ribosa-Nogué, R., Sala, I., Sánchez-Saudinós, M. B., García-Sebastian, M., Villanúa, J., Izagirre, A., Estanga, A., Ecay-Torres, M., Iriondo, A., Clerigue, M. & 10 others, Tainta, M., Pozueta, A., González, A., Martínez-Heras, E., Llufriu, S., Blesa, R., Sanchez-Juan, P., Martínez-Lage, P., Lleó, A. & Fortea, J., 1 Mar 2018, In: Alzheimer's and Dementia. 14, 3, p. 340-351

      Research output: Contribution to journalArticleResearchpeer-review

      45 Citations (Scopus)
    • CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum

      Illán-Gala, I., Alcolea, D., Montal, V., Dols-Icardo, O., Muñoz, L., De Luna, N., Turón-Sans, J., Cortés-Vicente, E., Belén Sánchez-Saudinós, M. A., Subirana, A., Sala, I., Blesa, R., Clarimón, J., Fortea, J., Rojas-García, R. & Lleó, A., 23 Oct 2018, In: Neurology. 91, p. E1619-E1628

      Research output: Contribution to journalArticleResearch

      36 Citations (Scopus)
    • Distinct clinical features and outcomes in motor neuron disease associated with behavioural variant frontotemporal dementia

      Cortés-Vicente, E., Turon-Sans, J., Gelpi, E., Clarimón, J., Borrego-Écija, S., Dols-Icardo, O., Illán-Gala, I., Lleó, A., Illa, I., Blesa, R., Al-Chalabi, A. & Rojas-Garciá, R., 1 Jul 2018, In: Dementia and Geriatric Cognitive Disorders. 45, 3-4, p. 220-231

      Research output: Contribution to journalArticleResearchpeer-review

      1 Citation (Scopus)
    • Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

      Broce, I., Karch, C. M., Wen, N., Fan, C. C., Wang, Y., Hong Tan, C., Kouri, N., Ross, O. A., Höglinger, G. U., Muller, U., Hardy, J., Momeni, P., Hess, C. P., Dillon, W. P., Miller, Z. A., Bonham, L. W., Rabinovici, G. D., Rosen, H. J., Schellenberg, G. D., Franke, A. & 80 others, Karlsen, T. H., Veldink, J. H., Ferrari, R., Yokoyama, J. S., Miller, B. L., Andreassen, O. A., Dale, A. M., Desikan, R. S., Sugrue, L. P., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Brooks, W. S., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Landqvist Waldö, M., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G. Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., G McKeith, I., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Pastor, P., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M. & Uphill, J., 1 Jan 2018, In: PLoS Medicine. 15, 1, e1002487.

      Research output: Contribution to journalArticleResearchpeer-review

      60 Citations (Scopus)
    • Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease

      Dekker, A. D., Vermeiren, Y., Carmona-Iragui, M., Benejam, B., Videla, L., Gelpi, E., Aerts, T., Van Dam, D., Fernández, S., Lleó, A., Videla, S., Sieben, A., Martin, J. J., Blesa, R., Fortea, J. & De Deyn, P. P., 1 Jan 2018, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 99-111

      Research output: Contribution to journalArticleResearchpeer-review

      4 Citations (Scopus)
    • Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

      Fortea, J., Carmona-Iragui, M., Benejam, B., Fernández, S., Videla, L., Barroeta, I., Alcolea, D., Pegueroles, J., Muñoz, L., Belbin, O., de Leon, M. J., Maceski, A. M., Hirtz, C., Clarimón, J., Videla, S., Delaby, C., Lehmann, S., Blesa, R. & Lleó, A., 1 Oct 2018, In: The Lancet Neurology. 17, p. 860-869

      Research output: Contribution to journalArticleResearch

      81 Citations (Scopus)
    • Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia

      Bergeron, D., Gorno-Tempini, M. L., Rabinovici, G. D., Santos-Santos, M. A., Seeley, W., Miller, B. L., Pijnenburg, Y., Keulen, M. A., Groot, C., van Berckel, B. N. M., van der Flier, W. M., Scheltens, P., Rohrer, J. D., Warren, J. D., Schott, J. M., Fox, N. C., Sanchez-Valle, R., Grau-Rivera, O., Gelpi, E., Seelaar, H. & 66 others, Papma, J. M., van Swieten, J. C., Hodges, J. R., Leyton, C. E., Piguet, O., Rogalski, E. J., Mesulam, M. M., Koric, L., Nora, K., Pariente, J., Dickerson, B., Mackenzie, I. R., Hsiung, G. Y. R., Belliard, S., Irwin, D. J., Wolk, D. A., Grossman, M., Jones, M., Harris, J., Mann, D., Snowden, J. S., Chrem-Mendez, P., Calandri, I. L., Amengual, A. A., Miguet-Alfonsi, C., Magnin, E., Magnani, G., Santangelo, R., Deramecourt, V., Pasquier, F., Mattsson, N., Nilsson, C., Hansson, O., Keith, J., Masellis, M., Black, S. E., Matías-Guiu, J. A., Cabrera-Martin, M. N., Paquet, C., Dumurgier, J., Teichmann, M., Sarazin, M., Bottlaender, M., Dubois, B., Rowe, C. C., Villemagne, V. L., Vandenberghe, R., Granadillo, E., Teng, E., Mendez, M., Meyer, P. T., Frings, L., Lleó, A., Blesa, R., Fortea, J., Seo, S. W., Diehl-Schmid, J., Grimmer, T., Frederiksen, K. S., Sánchez-Juan, P., Chételat, G., Jansen, W., Bouchard, R. W., Laforce, R. J., Visser, P. J. & Ossenkoppele, R., 1 Nov 2018, In: Annals of Neurology. 84, p. 729-740

      Research output: Contribution to journalArticleResearch

      46 Citations (Scopus)
    • Prevalence of sleep disorders in adults with down syndrome: A comparative study of self-reported, actigraphic, and polysomnographic findings

      Giménez, S., Videla, L., Romero, S., Benejam, B., Clos, S., Fernández, S., Martínez, M., Carmona-Iragui, M., Antonijoan, R. M., Mayos, M., Fortuna, A., Peñacoba, P., Plaza, V., Osorio, R. S., Sharma, R. A., Bardés, I., Rebillat, A. S., Lleó, A., Blesa, R., Videla, S. & 1 others, Fortea, J., 15 Oct 2018, In: Journal of Clinical Sleep Medicine. 14, p. 1725-1733

      Research output: Contribution to journalArticleResearch

      24 Citations (Scopus)
    • The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome

      Dekker, A. D., Sacco, S., Carfi, A., Benejam, B., Vermeiren, Y., Beugelsdijk, G., Schippers, M., Hassefras, L., Eleveld, J., Grefelman, S., Fopma, R., Bomer-Veenboer, M., Boti, M., Oosterling, G. D. E., Scholten, E., Tollenaere, M., Checkley, L., Strydom, A., Van Goethem, G., Onder, G. & 6 others, Blesa, R., Zu Eulenburg, C., Coppus, A. M. W., Rebillat, A. S., Fortea, J. & De Deyn, P. P., 1 Jan 2018, In: Journal of Alzheimer's Disease. 63, 2, p. 797-820

      Research output: Contribution to journalArticleResearchpeer-review

      19 Citations (Scopus)
    • 2017

      Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease

      Carmona-Iragui, M., Balasa, M., Benejam, B., Alcolea, D., Fernández, S., Videla, L., Sala, I., Sánchez-Saudinós, M. B., Morenas-Rodriguez, E., Ribosa-Nogué, R., Illán-Gala, I., Gonzalez-Ortiz, S., Clarimón, J., Schmitt, F., Powell, D. K., Bosch, B., Lladó, A., Rafii, M. S., Head, E., Molinuevo, J. L. & 5 others, Blesa, R., Videla, S., Lleó, A., Sánchez-Valle, R. & Fortea, J., 1 Nov 2017, In: Alzheimer's and Dementia. 13, 11, p. 1251-1260

      Research output: Contribution to journalArticleResearchpeer-review

      26 Citations (Scopus)
    • Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome

      Dekker, A. D., Fortea, J., Blesa, R. & De Deyn, P. P., 1 Jan 2017, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 8, p. 1-10

      Research output: Contribution to journalArticleResearchpeer-review

      20 Citations (Scopus)
    • Cerebrospinal fluid mitochondrial DNA in the Alzheimer's disease continuum

      Cervera-Carles, L., Alcolea, D., Estanga, A., Ecay-Torres, M., Izagirre, A., Clerigué, M., García-Sebastián, M., Villanúa, J., Escalas, C., Blesa, R., Martínez-Lage, P., Lleó, A., Fortea, J. & Clarimón, J., 1 May 2017, In: Neurobiology of Aging. 53, p. 192.e1-192.e4

      Research output: Contribution to journalArticleResearchpeer-review

      16 Citations (Scopus)
    • CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration

      Alcolea, D., Vilaplana, E., Suárez-Calvet, M., Illán-Gala, I., Blesa, R., Clarimón, J., Lladó, A., Sánchez-Valle, R., Molinuevo, J. L., García-Ribas, G., Compta, Y., Martí, M. J., Piñol-Ripoll, G., Amer-Ferrer, G., Noguera, A., García-Martín, A., Fortea, J. & Lleó, A., 11 Jul 2017, In: Neurology. 89, 2, p. 178-188

      Research output: Contribution to journalArticleResearchpeer-review

      64 Citations (Scopus)
    • Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer’s disease

      De Roeck, A., Van den Bossche, T., van der Zee, J., Verheijen, J., De Coster, W., Van Dongen, J., Dillen, L., Baradaran-Heravi, Y., Heeman, B., Sanchez-Valle, R., Lladó, A., Nacmias, B., Sorbi, S., Gelpi, E., Grau-Rivera, O., Gómez-Tortosa, E., Pastor, P., Ortega-Cubero, S., Pastor, M. A., Graff, C. & 39 others, Thonberg, H., Benussi, L., Ghidoni, R., Binetti, G., de Mendonça, A., Martins, M., Borroni, B., Padovani, A., Almeida, M. R., Santana, I., Diehl-Schmid, J., Alexopoulos, P., Clarimon, J., Lleó, A., Fortea, J., Tsolaki, M., Koutroumani, M., Matěj, R., Rohan, Z., De Deyn, P., Engelborghs, S., Cras, P., Van Broeckhoven, C., Sleegers, K., Bessi, V., Bagnoli, S., do Couto, F. S., Verdelho, A., Fratiglioni, L., Padovani, A., Rohan, Z., Razquin, C., Lorenzo, E., Iglesias, E., Seijo-Martínez, M., Rene, R., Gascon, J., Campdelacreu, J. & Blesa, R., 1 Sep 2017, In: Acta Neuropathologica. 134, 3, p. 475-487

      Research output: Contribution to journalArticleResearchpeer-review

      26 Citations (Scopus)
    • Diagnostic and Prognostic Value of the Combination of Two Measures of Verbal Memory in Mild Cognitive Impairment due to Alzheimer's Disease

      Sala, I., Illán-Gala, I., Alcolea, D., Sánchez-Saudinós, M. B., Salgado, S. A., Morenas-Rodríguez, E., Subirana, A., Videla, L., Clarimón, J., Carmona-Iragui, M., Ribosa-Nogué, R., Blesa, R., Fortea, J. & Lleó, A., 1 Jan 2017, In: Journal of Alzheimer's Disease. 58, 3, p. 909-918

      Research output: Contribution to journalArticleResearchpeer-review

      15 Citations (Scopus)
    • Effect size analyses of souvenaid in patients with Alzheimer's disease

      Cummings, J., Scheltens, P., Mckeith, I., Blesa, R., Harrison, J. E., Bertolucci, P. H. F., Rockwood, K., Wilkinson, D., Wijker, W., Bennett, D. A. & Shah, R. C., 1 Jan 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1131-1139

      Research output: Contribution to journalArticleResearchpeer-review

      28 Citations (Scopus)
    • Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome

      Carmona-Iragui, M., Santos, T., Videla, S., Fernández, S., Benejam, B., Videla, L., Alcolea, D., Blennow, K., Blesa, R., Lleó, A. & Fortea, J., 1 Jan 2017, In: Journal of Alzheimer's Disease. 55, 4, p. 1489-1496

      Research output: Contribution to journalArticleResearchpeer-review

      10 Citations (Scopus)
    • Longitudinal brain structural changes in preclinical Alzheimer's disease

      Pegueroles, J., Vilaplana, E., Montal, V., Sampedro, F., Alcolea, D., Carmona-Iragui, M., Clarimon, J., Blesa, R., Lleó, A. & Fortea, J., 1 May 2017, In: Alzheimer's and Dementia. 13, 5, p. 499-509

      Research output: Contribution to journalArticleResearchpeer-review

      36 Citations (Scopus)
    • Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS

      Taskesen, E., Mishra, A., van der Sluis, S., Ferrari, R., Veldink, J. H., van Es, M. A., Smit, A. B., Posthuma, D., Pijnenburg, Y., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L. & 80 others, Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Waldö, M. L., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G. Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Pastor, P., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Mead, S., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Van Broeckhoven, C., Cappa, S. F., Leber, I., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M. & Mayhaus, M., 1 Dec 2017, In: Scientific Reports. 7, 1, 8899.

      Research output: Contribution to journalArticleResearchpeer-review

      15 Citations (Scopus)
    • Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

      Colom-Cadena, M., Pegueroles, J., Herrmann, A. G., Henstridge, C. M., Muñoz, L., Querol-Vilaseca, M., Martín-Paniello, C. S., Luque-Cabecerans, J., Clarimon, J., Belbin, O., Núñez-Llaves, R., Blesa, R., Smith, C., McKenzie, C. A., Frosch, M. P., Roe, A., Fortea, J., Andilla, J., Loza-Alvarez, P., Gelpi, E. & 3 others, Hyman, B. T., Spires-Jones, T. L. & Lleó, A., 1 Dec 2017, In: Brain. 140, 12, p. 3204-3214

      Research output: Contribution to journalArticleResearchpeer-review

      44 Citations (Scopus)
    • Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer's disease

      Jimenez, A., Pegueroles, J., Carmona-Iragui, M., Vilaplana, E., Montal, V., Alcolea, D., Videla, L., Gala, I. I., Pané, A., Casajoana, A., Belbin, O., Clarimón, J., Moizé, V., Vidal, J., Lleó, A., Fortea, J. & Blesa, R., 1 Jan 2017, In: Oncotarget. 8, 62, p. 104706-104716

      Research output: Contribution to journalArticleResearchpeer-review

      20 Citations (Scopus)
    • 2016

      Assessing the role of TUBA4A gene in frontotemporal degeneration

      Dols-Icardo, O., Iborra, O., Valdivia, J., Pastor, P., Ruiz, A., de Munain, A. L., Sánchez-Valle, R., Álvarez, V., Sánchez-Juan, P., Lleó, A., Fortea, J., Blesa, R., Cardona, F., Baquero, M., Alonso, M. D., Ortega-Cubero, S., Pastor, M. A., Razquin, C., Boada, M., Hernández, I. & 8 others, Gorostidi, A., Moreno, F., Zulaika, M., Lladó, A., Coto, E., Combarros, O., Pérez-Tur, J. & Clarimón, J., 1 Jan 2016, In: Neurobiology of Aging. 38, p. 215.e13-215.e14

      Research output: Contribution to journalArticleResearchpeer-review

      6 Citations (Scopus)
    • Cerebrospinal Fluid Anti-Amyloid-Beta; Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation

      Carmona-Iragui, M., Fernández-Arcos, A., Alcolea, D., Piazza, F., Morenas-Rodriguez, E., Antón-Aguirre, S., Sala, I., Clarimon, J., Dols-Icardo, O., Camacho, V., Sampedro, F., Munuera, J., Nuñez-Marin, F., Lleó, A., Fortea, J., Gómez-Ansón, B. & Blesa, R., 1 Jan 2016, In: Journal of Alzheimer's Disease. 50, 1, p. 1-7

      Research output: Contribution to journalArticleResearchpeer-review

      19 Citations (Scopus)
    • Exome sequencing in a consanguineous family clinically diagnosed with early-onset Alzheimer's disease identifies a homozygous CTSF mutation

      Bras, J., Djaldetti, R., Alves, A. M., Mead, S., Darwent, L., Lleo, A., Molinuevo, J. L., Blesa, R., Singleton, A., Hardy, J., Clarimon, J. & Guerreiro, R., 1 Oct 2016, In: Neurobiology of Aging. 46, p. 236.e1-236.e6

      Research output: Contribution to journalArticleResearchpeer-review

      13 Citations (Scopus)
    • Progranulin protein levels in cerebrospinal fluid in primary neurodegenerative dementias

      Morenas-Rodríguez, E., Cervera-Carles, L., Vilaplana, E., Alcolea, D., Carmona-Iragui, M., Dols-Icardo, O., Ribosa-Nogué, R., Muñoz-Llahuna, L., Sala, I., Belén Sánchez-Saudinós, M., Blesa, R., Clarimón, J., Fortea, J. & Lleó, A., 10 Jan 2016, In: Journal of Alzheimer's Disease. 50, 2, p. 539-546

      Research output: Contribution to journalArticleResearchpeer-review

      27 Citations (Scopus)
    • sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

      Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., Heneka, M. T., Struyfs, H., Engelborghs, S., Sleegers, K. & 7 others, Van Broeckhoven, C., Zetterberg, H., Nellgård, B., Blennow, K., Crispin, A., Ewers, M. & Haass, C., 1 May 2016, In: EMBO Molecular Medicine. 8, 5, p. 466-476

      Research output: Contribution to journalArticleResearchpeer-review

      207 Citations (Scopus)
    • 2015

      Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease

      Alcolea, D., Martínez-Lage, P., Sánchez-Juan, P., Olazarán, J., Antúnez, C., Izagirre, A., Ecay-Torres, M., Estanga, A., Clerigué, M., Guisasola, M. C., Sánchez Ruiz, D., Marín Muñoz, J., Calero, M., Blesa, R., Clarimón, J., Carmona-Iragui, M., Morenas-Rodríguez, E., Rodríguez-Rodríguez, E., Vázquez Higuera, J. L., Fortea, J. & 1 others, Lleó, A., 1 Jan 2015, In: Neurology. 85, 7, p. 626-633

      Research output: Contribution to journalArticleResearchpeer-review

      101 Citations (Scopus)
    • APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls

      Sampedro, F., Vilaplana, E., de Leon, M. J., Alcolea, D., Pegueroles, J., Montal, V., Carmona-Iragui, M., Sala, I., Sánchez-Saudinos, M. B., Antón-Aguirre, S., Morenas-Rodríguez, E., Camacho, V., Falcón, C., Pavía, J., Ros, D., Clarimón, J., Blesa, R., Lleó, A. & Fortea, J., 1 Jan 2015, In: Oncotarget. 6, 29, p. 26663-26674

      Research output: Contribution to journalArticleResearchpeer-review

      61 Citations (Scopus)
    • Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: An ARIA before the tsunami

      Martínez-Lizana, E., Carmona-Iragui, M., Alcolea, D., Gómez-Choco, M., Vilaplana, E., Sánchez-Saudinós, M. B., Clarimón, J., Hernández-Guillamon, M., Munuera, J., Gelpi, E., Gómez-Anson, B., De Juan-Delago, M., Delgado-Mederos, R., Montaner, J., Ois, A., Amaro, S., Blesa, R., Martí-Fàbregas, J., Lleó, A. & Fortea, J., 1 Jan 2015, In: Journal of Cerebral Blood Flow and Metabolism. 35, 5, p. 710-717

      Research output: Contribution to journalArticleResearchpeer-review

      21 Citations (Scopus)
    • Early cerebellar hypometabolism in patients with frontotemporal dementia carrying the C9orf72 expansion

      Suárez-Calvet, M., Camacho, V., Gómez-Ansón, B., Antón, S., Vives-Gilabert, Y., Dols-Icardo, O., Clarimón, J., Alcolea, D., Blesa, R., Fortea, J. & Lleó, A., 1 Jan 2015, In: Alzheimer Disease and Associated Disorders. 29, 4, p. 353-356

      Research output: Contribution to journalArticleResearchpeer-review

      5 Citations (Scopus)
    • PLD3 in non-familial Alzheimer's disease

      Heilmann, S., Drichel, D., Clarimon, J., Fernández, V., Lacour, A., Wagner, H., Thelen, M., Hernández, I., Fortea, J., Alegret, M., Blesa, R., Mauleón, A., Roca, M. R., Kornhuber, J., Peters, O., Heun, R., Frölich, L., Hüll, M., Heneka, M. T., Rüther, E. & 12 others, Riedel-Heller, S., Scherer, M., Wiltfang, J., Jessen, F., Becker, T., Tárraga, L., Boada, M., Maier, W., Lleó, A., Ruiz, A., Nöthen, M. M. & Ramirez, A., 2 Apr 2015, In: Nature. 520, 7545, p. E3-E5

      Research output: Contribution to journalArticleResearchpeer-review

      46 Citations (Scopus)
    • Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

      Alcolea, D., Vilaplana, E., Pegueroles, J., Montal, V., Sánchez-Juan, P., González-Suárez, A., Pozueta, A., Rodríguez-Rodríguez, E., Bartrés-Faz, D., Vidal-Piñeiro, D., González-Ortiz, S., Medrano, S., Carmona-Iragui, M., Sánchez-Saudinós, M. B., Sala, I., Anton-Aguirre, S., Sampedro, F., Morenas-Rodríguez, E., Clarimón, J., Blesa, R. & 2 others, Lleó, A. & Fortea, J., 1 Jun 2015, In: Neurobiology of Aging. 36, 6, p. 2018-2023

      Research output: Contribution to journalArticleResearchpeer-review

      57 Citations (Scopus)
    • 2014

      Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

      Ruiz, A., Dols-Icardo, O., Bullido, M. J., Pastor, P., Rodríguez-Rodríguez, E., López de Munain, A., de Pancorbo, M. M., Pérez-Tur, J., Álvarez, V., Antonell, A., López-Arrieta, J., Hernández, I., Tárraga, L., Boada, M., Lleó, A., Blesa, R., Frank-García, A., Sastre, I., Razquin, C., Ortega-Cubero, S. & 10 others, Lorenzo, E., Sánchez-Juan, P., Combarros, O., Moreno, F., Gorostidi, A., Elcoroaristizabal, X., Baquero, M., Coto, E., Sánchez-Valle, R. & Clarimón, J., 1 Jan 2014, In: Neurobiology of Aging. 35, 2, p. 444.e1-444.e4

      Research output: Contribution to journalArticleResearchpeer-review

      77 Citations (Scopus)
    • Cerebrospinal fluid β-amyloid and phospho-tau biomarker interactions affecting brain structure in preclinical Alzheimer disease

      Fortea, J., Vilaplana, E., Alcolea, D., Carmona-Iragui, M., Sánchez-Saudinos, M. B., Sala, I., Antón-Aguirre, S., González, S., Medrano, S., Pegueroles, J., Morenas, E., Clarimón, J., Blesa, R. & Lleó, A., 1 Jan 2014, In: Annals of Neurology. 76, 2, p. 223-230

      Research output: Contribution to journalArticleResearchpeer-review

      74 Citations (Scopus)
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