Research output per year
Research output per year
- 22 results
Search results
-
2024
Broad-spectrum ubiquitin/ubiquitin-like deconjugation activity of the rhizobial effector NopD from Bradyrhizobium (sp. XS1150)
Varejao Nogueira, N., Varejão, N., Reverter, D., Lois, M., Perez-Gil, J. & Li, Y., 27 May 2024, In: Communications Biology. 7, 11 p., 644.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
2023
A termiticidal and high denaturation-resistant lectin from Moringa oleifera seed cake
Varejao Nogueira, N., Sept 2023, In: Journal of Natural Pesticide Research. 5, 9 p., 100040.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
PITB : A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties
Pinheiro, F., Varejão, N., Sánchez-Morales, A., Bezerra, F., Navarro, S., Velázquez-Campoy, A., Busqué Sánchez, F., Almeida, M. R., Alibes, R., Reverter, D., Pallarès i Goitiz, I. & Ventura, S., 5 Dec 2023, In: CHIM.THER.. 261, 10 p., 115837.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
2022
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation
Pinheiro, F., Pallarès, I., Peccati, F., Sánchez-Morales, A., Varejão, N., Bezerra, F., Ortega-Alarcon, D., Gonzalez, D., Osorio, M., Navarro, S., Velázquez-Campoy, A., Almeida, M. R., Reverter, D., Busqué, F., Alibés, R., Sodupe, M. & Ventura, S., 10 Nov 2022, In: Journal of Medicinal Chemistry. 65, 21, p. 14673-14691 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)3 Downloads (Pure) -
Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1
Li, Y., Reverter, D. & Varejao Nogueira, N., 5 Apr 2022, In: Nature communications. 13, 12 p., 1819.Research output: Contribution to journal › Article › Research › peer-review
Open Access18 Citations (Scopus) -
2021
Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation
Esperante, S. A., Varejao, N., Pinheiro, F., Sant'Anna, R., Luque-Ortega, J. R., Alfonso, C., Sora, V., Papaleo, E., Rivas, G., Reverter, D. & Ventura, S., 1 Sept 2021, In: Journal of Biological Chemistry. 297, 3, 101039.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
Lascorz, J., Codina-Fabra, J., Torres-Rosell, J., Reverter, D., Varejão, N., Borràs-Gas, H. & Bellí, G., Dec 2021, In: Nature communications. 12, 1, 7013.Research output: Contribution to journal › Article › Research › peer-review
Open Access22 Citations (Scopus) -
2020
Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis
Pinheiro, F., Varejão, N., Esperante, S., Santos, J., Velázquez‐Campoy, A., Reverter, D., Pallarès, I. & Ventura, S., 11 May 2020, In: FEBS Journal. 288, 1, p. 310-324 15 p.Research output: Contribution to journal › Article › Research › peer-review
42 Citations (Scopus) -
2018
Combining Structural Aggregation Propensity and Stability Predictions to Redesign Protein Solubility
Gil-Garcia, M., Banó-Polo, M., Varejao, N., Jamroz, M., Kuriata, A., Díaz-Caballero, M., Lascorz, J., Morel, B., Navarro, S., Reverter, D., Kmiecik, S. & Ventura, S., 4 Sept 2018, In: Molecular Pharmaceutics. 15, p. 3846-3859Research output: Contribution to journal › Article › Research
43 Citations (Scopus) -
DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex
Varejão, N., Ibars, E., Lascorz, J., Colomina, N., Torres-Rosell, J. & Reverter, D., 15 Jun 2018, In: EMBO Journal. 37, 12, e98306.Research output: Contribution to journal › Article › Research › peer-review
42 Citations (Scopus) -
Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase
Varejão, N., De-Andrade, R. A., Almeida, R. V., Anobom, C. D., Foguel, D. & Reverter, D., 6 Feb 2018, In: Structure. 26, 2, p. 199-208.e3Research output: Contribution to journal › Article › Research › peer-review
13 Citations (Scopus) -
2017
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation
Sant'Anna, R., Almeida, M. R., Varejao, N., Gallego, P., Esperante, S., Ferreira, P., Pereira-Henriques, A., Palhano, F. L., De Carvalho, M., Foguel, D., Reverter, D., Saraiva, M. J. & Ventura, S., 24 Mar 2017, In: Scientific Reports. 7, 44709.Research output: Contribution to journal › Article › Research › peer-review
23 Citations (Scopus) -
pCramoll and rCramoll lectins induce cell death in human prostate adenocarcinoma (PC-3) cells by impairment of mitochondrial homeostasis
de Oliveira Figueirôa, E., Aranda-Souza, M. Â., Rossato, F. A., Costa, R. A. P., Figueira, T. R., da Silva, L. C. N., Castilho, R. F., Vercesi, A. E., dos Santos Correia, M. T. & Varejao Nogueira, N., Sept 2017, In: Toxicology in Vitro. 43, p. 40-46 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
2016
Encapsulation into stealth liposomes enhances the antitumor action of recombinant Cratylia mollis lectin expressed in Escherichia coli
da Cunha, C. R. A., da Silva, L. C. N., Almeida, F. J. F., Ferraz, M. S., Varejão, N., Cartaxo, M. F. D. S., de Miranda, R. D. C. M., de Aguiar, F. C. A., Santos, N. P. D. S., Coelho, L. C. B. B., Santos-Magalhães, N. S. & Correia, M. T. D. S., 16 Sept 2016, In: Frontiers in Microbiology. 7, SEP, 11 p., 1355.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
2015
Identification of a new variant of TTR involved in familial amyloid cardiomyopathy (FAC) in Brazil: from the patient to the protein.
Ferreira, P., Andrade, C., Santanna, R., Varejão, N., Ventura, S., Palhano, F., Cruz, M. & Foguel, D., 2015, In: Orphanet Journal of Rare Diseases.Research output: Contribution to journal › Article › Research › peer-review
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Immunomodulatory effects of pCramoll and rCramoll on peritoneal exudate cells (PECs) infected and non-infected with Staphylococcus aureus
da Silva, L. C. N., Alves, N. M. P., de Castro, M. C. A. B., Pereira, V. R. A., Coelho, L. C. B. B., de Figueiredo, R. C. B. Q., Correia, M. T. D. S. & Varejao Nogueira, N., 1 Jan 2015, In: International journal of biological macromolecules. 72, p. 848-854 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access31 Citations (Scopus) -
PCramoll and rCramoll as New Preventive Agents against the Oxidative Dysfunction Induced by Hydrogen Peroxide
Da Silva, L. C. N., Alves, N. M. P., De Castro, M. C. A. B., Higino, T. M. M., Da Cunha, C. R. A., Pereira, V. R. A., Coelho, L. C. B. B., Correia, M. T. D. S., De Figueiredo, R. C. B. Q. & Varejao Nogueira, N., 2015, In: Oxidative Medicine and Cellular Longevity. 2015, 520872.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
2014
The importance of a gatekeeper residue on the aggregation of transthyretin implications for transthyretin-related amyloidoses
Sant'Anna, R., Braga, C., Varejão, N., Pimenta, K. M., Granã-Montes, R., Alves, A., Cortines, J., Cordeiro, Y., Ventura, S. & Foguel, D., 10 Oct 2014, In: Journal of Biological Chemistry. 289, 41, p. 28324-28337Research output: Contribution to journal › Article › Research › peer-review
35 Citations (Scopus) -
2013
Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy
Ferreira, P., Sant'Anna, O., Varejão, N., Lima, C., Novis, S., Barbosa, R. V., Caldeira, C. M., Rumjanek, F. D., Ventura, S., Cruz, M. W. & Foguel, D., 17 Dec 2013, In: PLoS ONE. 8, 12, e82484.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
2011
Characterization of the unfolding process of the tetrameric and dimeric forms of Cratylia mollis seed lectin (CRAMOLL 1): Effects of natural fragmentation on protein stability
Correia, M. T. S., Foguel, D. & Varejao Nogueira, N., 30 Aug 2011, In: Biochemistry. 50, 34, p. 7330-7340 11 p.Research output: Contribution to journal › Article › Research › peer-review
21 Citations (Scopus) -
2010
Heterologous expression and purification of a biologically active legume lectin from Cratylia mollis seeds (CRAMOLL 1)
Almeida, M. D. S., De Cicco, N. N. T., Atella, G. C., Coelho, L. C. B. B., Correia, M. T. S., Foguel, D. & Varejao Nogueira, N., Sept 2010, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1804, 9, p. 1917-1924 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access19 Citations (Scopus) -
2009
Ferromagnetic levan composite: An affinity matrix to purify lectin
Angeli, R., MacIel, J. C., Araújo, F. F. B., Paiva, P. M. G., Calazans, G. M. T., Valente, A. P., Almeida, F. C. L., Coelho, L. C. B. B., Carvalho, L. B., Silva, M. D. P. C., Dos Santos Correia, M. T. & Varejao Nogueira, N., 2009, In: Journal of Biomedicine and Biotechnology. 2009, 179106.Research output: Contribution to journal › Article › Research › peer-review
Open Access20 Citations (Scopus)