Mª Margarita Julià Sapé

2024

Early pseudoprogression and progression lesions in glioblastoma patients are both metabolically heterogeneous

Ungan, G., Pons-Escoda, A., Ulinic, D., Arús, C., Olier, I., Vellido, A., Majós, C. & Julià-Sapé, M., Apr 2024, In: NMR in Biomedicine. 37, 4, 12 p., e5095.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)

2023

A comparison of non-negative matrix underapproximation methods for the decomposition of magnetic resonance spectroscopy data from human brain tumors

Ungan, G., Arús, C., Vellido, A. & Julià-Sapé, M., Dec 2023, In: NMR in Biomedicine. 36, 12, 18 p., e5020.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)

2 Downloads (Pure)

Using Single-Voxel Magnetic Resonance Spectroscopy Data Acquired at 1.5T to Classify Multivoxel Data at 3T: A Proof-of-Concept Study

Ungan, G., Pons Escoda, A., Ulinic, D., Arus Caralto, C., Vellido, A. & Julià-Sapé, M., 21 Jul 2023, In: Cancers. 15, 14, p. 1-24 24 p., 3709.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

5 Downloads (Pure)

2022

Extraction of artefactual MRS patterns from a large database using non-negative matrix factorization

Hernández-Villegas, Y., Ortega-Martorell, S., Arús, C., Vellido, A. & Julià-Sapé, M., Apr 2022, In: NMR in Biomedicine. e4193.

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

2020

Anti-tumour immune response in GL261 glioblastoma generated by Temozolomide Immune-Enhancing Metronomic Schedule monitored with MRSI-based nosological images

Wu, S., Calero-Pérez, P., Villamañan, L., Arias-Ramos, N., Pumarola, M., Ortega-Martorell, S., Julià-Sapé, M., Arús, C. & Candiota, A. P., 11 Jan 2020, In: NMR in Biomedicine. 33, 4, e4229.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

17 Citations (Scopus)

Detecció no invasiva de la participació del sistema immunitari en la resposta a la teràpia en glioblastoma en un model preclínic de ratolí immunocompetent

Wu, S., Calero-Perez, P., Villamañán de Santiago, L., Arias-Ramos, N., Pumarola i Batlle, M., Ortega-Martorell, S., Julià Sapé, M. M., Arús i Caraltó, C. & Candiota Silveira, A. P., 2020, In: UAB Divulga.

Research output: Contribution to journal › Article › Dissemination

Open Access

Robust Conditional Independence maps of single-voxel Magnetic Resonance Spectra to elucidate associations between brain tumours and metabolites

Casaña-Eslava, R. V., Ortega-Martorell, S., Lisboa, P. J., Candiota, A. P., Julià-Sapé, M., Martín-Guerrero, J. D. & Jarman, I. H., Jul 2020, In: PLoS ONE. 15, 7, e0235057.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2 Citations (Scopus)

2019

Embedding MRI information into MRSI data source extraction improves brain tumour delineation in animal models

Ortega-Martorell, S., Candiota, A. P., Thomson, R., Riley, P., Julia-Sape, M. & Olier, I., 1 Jan 2019, In: PLoS ONE. 14, 8, e0220809.

Research output: Contribution to journal › Article › Research

3 Citations (Scopus)

2018

Quality of clinical brain tumor MR spectra judged by humans and machine learning tools

Kyathanahally, S. P., Mocioiu, V., Pedrosa de Barros, N., Slotboom, J., Wright, A. J., Julià-Sapé, M., Arús, C. & Kreis, R., 1 May 2018, In: Magnetic Resonance in Medicine. 79, 5, p. 2500-2510

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

2017

Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke

Jiménez-Xarrié, E., Davila, M., Candiota, A. P., Delgado-Mederos, R., Ortega-Martorell, S., Julià-Sapé, M., Arús, C. & Martí-Fàbregas, J., 13 Jan 2017, In: BMC Neuroscience. 18, 1, 13.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

4 Citations (Scopus)

Metabolomics of therapy response in preclinical glioblastoma: A multi-slice MRSI-based volumetric analysis for noninvasive assessment of temozolomide treatment

Pumarola Batlle, M., Julià-Sapé, M., Arus Caralto, C., Candiota Silveira, A. P., Ferrer Font, L., Mocioiu, V., Lope Piedrafita, S. & Arias Ramos, N., 1 Jun 2017, In: Metabolites. 7, 2, 20.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

16 Citations (Scopus)

Metronomic treatment in immunocompetent preclinical GL261 glioblastoma: effects of cyclophosphamide and temozolomide

Ferrer-Font, L., Arias-Ramos, N., Lope-Piedrafita, S., Julià-Sapé, M., Pumarola, M., Arús, C. & Candiota, A. P., 1 Sept 2017, In: NMR in Biomedicine. 30, 9, e3748.

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

2016

MRSI-based molecular imaging of therapy response to temozolomide in preclinical glioblastoma using source analysis

Pumarola Batlle, M., Arus Caralto, C., Fernandez Flores, F., Julia Sape, M. M., Candiota Silveira, A. P., Ciezka, M., Delgado-Goñi, T., Ortega-Martorell, S., Olier, I. & Lisboa, P. J., 1 Jun 2016, In: NMR in Biomedicine. 29, 6, p. 732-743

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Web of Science)

2015

Classification of brain tumours from MR spectra: The INTERPRET collaboration and its outcomes

Julià-Sapé, M., Griffiths, J. R., Tate, R. A., Howe, F. A., Acosta, D., Postma, G., Underwood, J., Majós, C. & Arús, C., 1 Dec 2015, In: NMR in Biomedicine. 28, 12, p. 1772-1787

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Clinical trials of MRS methods

Julia-Sape, M., Arias-Mendoza, F. & Griffiths, J. R., 1 Jan 2015, In: eMagRes. 4, 4, p. 779-788 10 p.

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

From raw data to data-analysis for magnetic resonance spectroscopy - the missing link: JMRUI2XML

Mocioiu, V., Ortega-Martorell, S., Olier, I., Jablonski, M., Starcukova, J., Lisboa, P., Arús, C. & Julià-Sapé, M., 9 Nov 2015, In: BMC Bioinformatics. 16, 378.

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Robustness of equations that define molecular subtypes of glioblastoma tumors based on five transcripts measured by RT-PCR

Castells, X., Acebes, J. J., Majós, C., Boluda, S., Julià-Sapé, M., Candiota, A. P., Ariño, J., Barceló, A. & Arús, C., 1 Jan 2015, In: OMICS A Journal of Integrative Biology. 19, 1, p. 41-51

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

2014

Molecular imaging coupled to pattern recognition distinguishes response to temozolomide in preclinical glioblastoma

Pumarola Batlle, M., Arus Caralto, C., Candiota Silveira, A. P., Julia Sape, M. M. & Delgado Goñi, T., 1 Nov 2014, In: NMR in Biomedicine. 27, 11, p. 1333-1345 13 p.

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Multicentre evaluation of the INTERPRET decision support system 2.0 for brain tumour classification

Julià-Sapé, M., Majós, C., Camins, À., Samitier, A., Baquero, M., Serrallonga, M., Doménech, S., Grivé, E., Howe, F. A., Opstad, K., Calvar, J., Aguilera, C. & Arús, C., 1 Jan 2014, In: NMR in Biomedicine. 27, p. 1009-1018

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

2013

A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data

Ortega-Martorell, S., Ruiz, H., Vellido, A., Olier, I., Romero, E., Julià-Sapé, M., Martín, J. D., Jarman, I. H., Arús, C. & Lisboa, P. J. G., 23 Dec 2013, In: PLoS ONE. 8, e83773.

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

2012

Convex Non-Negative Matrix Factorization for Brain Tumor Delimitation from MRSI Data

Pumarola Batlle, M., Arus Caralto, C., Julia Sape, M. M., Ortega Martorell, S., Lisboa, P. J. G., Vellido, A. & Simões, R. V., 23 Oct 2012, In: PLoS ONE. 7, 10, e47824.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

37 Citations (Scopus)

Development of robust discriminant equations for assessing subtypes of glioblastoma biopsies

Castells, X., Acebes, J. J., Majós, C., Boluda, S., Julià-Sapé, M., Candiota, A. P., Ariño, J., Barceló, A. & Arús, C., 22 May 2012, In: British Journal of Cancer. 106, p. 1816-1825

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSI

Simões, R. V., Ortega-Martorell, S., Delgado-Goñi, T., Fur, Y. L., Pumarola, M., Candiota, A. P., Martín, J., Stoyanova, R., Cozzone, P. J., Julià-Sapé, M. & Arús, C., Feb 2012, In: Integrative Biology. 4, 2, p. 183-191 9 p.

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Non-negative matrix factorisation methods for the spectral decomposition of MRS data from human brain tumours

Ortega-Martorell, S., Lisboa, P. J. G., Vellido, A., Julià-Sapé, M. & Arús, C., 8 Mar 2012, In: BMC Bioinformatics. 13, 38.

Research output: Contribution to journal › Article › Research › peer-review

30 Citations (Scopus)

Prospective diagnostic performance evaluation of single-voxel ¹H MRS for typing and grading of brain tumours

Julià-Sapé, M., Coronel, I., Majós, C., Candiota, A. P., Serrallonga, M., Cos, M., Aguilera, C., Acebes, J. J., Griffiths, J. R. & Arús, C., 1 Apr 2012, In: NMR in Biomedicine. 25, 4, p. 661-673 13 p.

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Robust discrimination of glioblastomas from metastatic brain tumors on the basis of single-voxel ¹H MRS

Vellido, A., Romero, E., Julià-Sapé, M., Majós, C., Moreno-Torres, À., Pujol, J. & Arús, C., 1 Jun 2012, In: NMR in Biomedicine. 25, p. 819-828

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

Strategies for annotation and curation of translational databases: the eTUMOUR project.

Julià-Sapé, M., Lurgi, M., Mier, M., Estanyol, F., Rafael, X., Candiota, A. P., Barceló, A., García, A., Martínez-Bisbal, M. C., Ferrer-Luna, R., Moreno-Torres, Á., Celda, B. & Arús, C., 1 Jan 2012, In: Database : the journal of biological databases and curation. 2012

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

2011

Compatibility between 3T ¹H SV-MRS data and automatic brain tumour diagnosis support systems based on databases of 1.5T ¹H SV-MRS spectra

Fuster-Garcia, E., Navarro, C., Vicente, J., Tortajada, S., García-Gómez, J. M., Sáez, C., Calvar, J., Griffiths, J., Julià-Sapé, M., Howe, F. A., Pujol, J., Peet, A. C., Heerschap, A., Moreno-Torres, À., Martínez-Bisbal, M. C., Martínez-Granados, B., Wesseling, P., Semmler, W., Capellades, J. & Majós, C. & 7 others, Alberich-Bayarri, À., Capdevila, A., Monleón, D., Martí-Bonmatí, L., Arús, C., Celda, B. & Robles, M., 1 Feb 2011, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 24, p. 35-42

Research output: Contribution to journal › Article › Research › peer-review

Open Access

17 Citations (Scopus)

Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis

Tortajada, S., Fuster-Garcia, E., Vicente, J., Wesseling, P., Howe, F. A., Julià-Sapé, M., Candiota, A. P., Monleón, D., Moreno-Torres, À., Pujol, J., Griffiths, J. R., Wright, A., Peet, A. C., Martínez-Bisbal, M. C., Celda, B., Arús, C., Robles, M. & García-Gómez, J. M., 1 Aug 2011, In: Journal of Biomedical Informatics. 44, p. 677-687

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Non-invasive grading of astrocytic tumours from the relative contents of myo-inositol and glycine measured by in vivo MRS

Candiota, A. P., Majós, C., Julià-Sapé, M., Cabañas, M., Acebes, J. J., Moreno-Torres, A., Griffiths, J. R. & Arús, C., 1 Jan 2011, In: JBR-BTR. 94, 6, p. 319-329

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

On the relevance of automatically selected single-voxel MRS and multimodal MRI and MRSI features for brain tumour differentiation

Postma, G. J., Luts, J., Idema, A. J., Julià-Sapé, M., Moreno-Torres, Á., Gajewicz, W., Suykens, J. A. K., Heerschap, A., Van Huffel, S. & Buydens, L. M. C., 1 Feb 2011, In: Computers in Biology and Medicine. 41, p. 87-97

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

2010

Development of a predictor for human brain tumors based on gene expression values obtained from two types of microarray technologies

Castells, X., Acebes, J. J., Boluda, S., Moreno-Torres, À., Pujol, J., Julià-Sapé, M., Candiota, A. P., Ariño, J., Barceló, A. & Arús, C., 1 Apr 2010, In: OMICS A Journal of Integrative Biology. 14, 2, p. 157-164

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Development of a predictor for human brain tumours based on gene expression values obtained from two types of microarray technologies

Castells, X., Acebes, J. J., Boluda, S., Moreno, A., Pujol, J., Julià-Sapé, M., Candiota, A. P., Barceló, A. & Arús, C., 1 Jan 2010, In: Omics. 14, p. 157-164

Research output: Contribution to journal › Article › Research

10 Citations (Scopus)

Feature and model selection with discriminatory visualization for diagnostic classification of brain tumors

González-Navarro, F. F., Belanche-Muñoz, L. A., Romero, E., Vellido, A., Julià-Sapé, M. & Arús, C., 1 Jan 2010, In: Neurocomputing. 73, 4-6, p. 622-632

Research output: Contribution to journal › Article › Research

SpectraClassifier 1.0: A user friendly, automated MRS-based classifier-development system

Ortega-Martorell, S., Olier, I., Julià-Sapé, M. & Arús, C., 24 Feb 2010, In: BMC Bioinformatics. 11, 106.

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses

Pérez-Ruiz, A., Julià-Sapé, M., Mercadal, G., Olier, I., Majós, C. & Arús, C., 29 Nov 2010, In: BMC Bioinformatics. 11, 581.

Research output: Contribution to journal › Article › Research › peer-review

40 Citations (Scopus)

2009

HealthAgents: Distributed multi-agent brain tumor diagnosis and prognosis

González-Vélez, H., Mier, M., Julià-Sapé, M., Arvanitis, T. N., García-Gómez, J. M., Robles, M., Lewis, P. H., Dasmahapatra, S., Dupplaw, D., Peet, A., Arús, C., Celda, B., Van Huffel, S. & Lluch-Ariet, M., 1 Jun 2009, In: Applied Intelligence. 30, p. 191-202

Research output: Contribution to journal › Article › Research › peer-review

69 Citations (Scopus)

Multiproject-multicenter evaluation of automatic brain tumor classification by magnetic resonance spectroscopy

García-Gómez, J. M., Luts, J., Julià-Sapé, M., Krooshof, P., Tortajada, S., Robledo, J. V., Melssen, W., Fuster-García, E., Olier, I., Postma, G., Monleón, D., Moreno-Torres, À., Pujol, J., Candiota, A. P., Martínez-Bisbal, M. C., Suykens, J., Buydens, L., Celda, B., Van Huffel, S. & Arús, C. & 1 others, Robles, M., 1 Feb 2009, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 22, p. 5-18

Research output: Contribution to journal › Article › Research › peer-review

122 Citations (Scopus)

Outlier exploration and diagnostic classification of a multi-centre H-1-MRS brain tumour database

Vellido, A., Romero, E., González-Navarro, F. F., Belanche-Muñoz, L. A., Juliá-Sapé, M. & Arús, C., 1 Jan 2009, In: Neurocomputing. 72, 13-15, p. 3085-3097

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

Proton MR spectroscopy improves discrimination between tumor and pseudotumoral lesion in solid brain masses

Majós, C., Aguilera, C., Alonso, J., Julià-Sapé, M., Castañer, S., Sánchez, J. J., Samitier, Á., León, A., Rovira, Á. & Arús, C., 1 Mar 2009, In: American Journal of Neuroradiology. 30, p. 544-551

Research output: Contribution to journal › Article › Research › peer-review

84 Citations (Scopus)

2008

MRS quality assessment in a multicentre study on MRS-based classification of brain tumours

van der Graaf, M., Julià-Sapé, M., Howe, F. A., Ziegler, A., Majós, C., Moreno-Torres, A., Rijpkema, M., Acosta, D., Opstad, K. S., van der Meulen, Y. M., Arús, C. & Heerschap, A., 1 Feb 2008, In: NMR in Biomedicine. 21, p. 148-158

Research output: Contribution to journal › Article › Research › peer-review

41 Citations (Scopus)

The effect of combining two echo times in automatic brain tumor classification by MRS

García-Gómez, J. M., Tortajada, S., Vidal, C., Julià-Sape, M., Luts, J., Moreno-Torres, A., Van Huffel, S., Arús, C. & Robles, M., 1 Dec 2008, In: NMR in Biomedicine. 21, p. 1112-1125

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

2006

A multi-centre, web-accessible and quality control-checked database of in vivo MR spectra of brain tumour patients

Julià-Sapé, M., Acosta, D., Mier, M., Arùs, C. & Watson, D., 1 Jan 2006, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 19, 1, p. 22-33

Research output: Contribution to journal › Article › Research › peer-review

74 Citations (Scopus)

Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database.

Julià-Sapé, M., Acosta, D., Majós, C., Moreno-Torres, A., Wesseling, P., Acebes, J. J., Griffiths, J. R. & Arús, C., 1 Jan 2006, In: Journal of Neurosurgery. 105, 1, p. 6-14

Research output: Contribution to journal › Article › Research

55 Citations (Scopus)

Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra

Tate, A. R., Underwood, J., Acosta, D. M., Julià-Sapé, M., Majós, C., Moreno-Torres, À., Howe, F. A., van der Graaf, M., Lefournier, V., Murphy, M. M., Loosemore, A., Ladroue, C., Wesseling, P., Bosson, J. L., Cabañas, M. E., Simonetti, A. W., Gajewicz, W., Calvar, J., Capdevilla, A. & Wilkins, P. R. & 6 others, Bell, B. A., Rémy, C., Heerschap, A., Watson, D., Griffiths, J. R. & Arús, C., 1 Jun 2006, In: NMR in Biomedicine. 19, p. 411-434

Research output: Contribution to journal › Article › Research › peer-review

203 Citations (Scopus)

2004

Brain tumor classification by proton MR spectroscopy: Comparison of diagnostic accuracy at short and long TE

Majós, C., Julià-Sapé, M., Alonso, J., Serrallonga, M., Aguilera, C., Acebes, J. J., Arús, C. & Gili, J., 1 Nov 2004, In: American Journal of Neuroradiology. 25, 10, p. 1696-1704

Research output: Contribution to journal › Article › Research › peer-review

169 Citations (Scopus)

2000

Protective effect of HOE642, a selective blocker of Na⁺-H⁺ exchange, against the development of rigor contracture in rat ventricular myocytes

Ruiz-Meana, M., Garcia-Dorado, D., Juliá, M., Inserte, J., Siegmund, B., Ladilov, Y., Piper, M., Tritto, F. P., González, M. A. & Soler-Soler, J., Jan 2000, In: Experimental Physiology. 85, 1, p. 17-25 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

23 Citations (Scopus)

1999

LDL and Lp(a) oxidation: Protective role of HDL

HURTADO, I., FIOL, C. & Julià-Sapé, M., 1999, In: Atherosclerosis.

Research output: Contribution to journal › Article › Research › peer-review

1997

Cell-to-cell transmission of hypercontracture through gap junctions

Ruiz-Meana, M., Garcia-Dorado, D., Julia, M., Hofstaetter, B., Piper, M., Inserte, J. & Soler, J., 1997, In: Journal of Molecular and Cellular Cardiology. 96, 10, p. 3579-3586 8 p.

Research output: Contribution to journal › Article › Research › peer-review

Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion

Garcia-Dorado, D., Inserte, J., Ruiz-Meana, M., González, M. A., Solares, J., Juliá, M., Barrabés, J. A. & Soler-Soler, J., 1 Jan 1997, In: Circulation (New York, N.Y.). 96, 10, p. 3579-3586

Research output: Contribution to journal › Article › Research

172 Citations (Scopus)

Mª Margarita Julià Sapé

Research output

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