Research output per year
Research output per year
- 48 results
Search results
-
2023
Capturing conformational transitions of full-length PDK1 that dictate kinase substrate selectivity
Martínez-Arenas, L. & Bayascas, J. R., 13 Jun 2023, In: Science Signaling. 16, 789, p. eadh5114 eadh5114.Research output: Contribution to journal › Article › Research › peer-review
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2022
Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
Zhang, Y., Chen, Y., Zhang, Z., Tao, X., Xu, S., Zhang, X., Zurashvili, T., Lu, Z., Bayascas, J. R., Jin, L., Zhao, J. & Zhou, X., 29 Mar 2022, In: Cell death and disease. 13, 3, p. 279 279.Research output: Contribution to journal › Article › Research › peer-review
Open Access27 Citations (Scopus)2 Downloads (Pure) -
Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1: Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
Garcia-Viloca, M., Bayascas, J. R., Lluch, J. M. & González-Lafont, À., 26 Jul 2022, In: ACS omega. 7, 29, p. 25186-25199 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival
Diéguez-Martínez, N., Espinosa-Gil, S., Yoldi, G., Megías-Roda, E., Bolinaga-Ayala, I., Viñas-Casas, M., Domingo-Ortí, I., Pérez-Montoyo, H., Bayascas, J. R., Colas, E., Dolcet, X. & Lizcano, J. M., 19 Sept 2022, In: Cellular and Molecular Life Sciences. 79, 10, p. 524 20 p., 524.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
2021
Fine-tuning the pi3k/akt signaling pathway intensity by sex and genotype-load: Sex-dependent homozygotic threshold for somatic growth but feminization of anxious phenotype in middle-aged pdk1 k465e knock-in and heterozygous mice
Santana-Santana, M., Bayascas, J. R. & Giménez-Llort, L., 28 Jun 2021, In: Biomedicines. 9, 7, 12 p., 747.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Gossypol treatment restores insufficient apoptotic function of dff40/cad in human glioblastoma cells
Martínez-Escardó, L., Alemany, M., Sánchez-Osuna, M., Sánchez-Chardi, A., Roig-Martínez, M., Suárez-García, S., Ruiz-Molina, D., Vidal, N., Plans, G., Majós, C., Ribas, J., Baltrons, M. A., Bayascas, J. R., Barcia, C., Bruna, J. & Yuste, V. J., 1 Nov 2021, In: Cancers. 13, 21, 5579.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Sex-dependent signatures, time frames and longitudinal fine-tuning of the marble burying test in normal and ad-pathological aging mice
Santana-Santana, M., Bayascas, J. R. & Giménez-Llort, L., 11 Aug 2021, In: Biomedicines. 9, 8, 16 p., 994.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus) -
2020
Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Alcaraz, E., Vilardell, J., Borgo, C., Sarro, E., Plana, M., Marin, O., Pinna, L. A., Bayascas, J. R., Meseguer, A., Salvi, M., Itarte, E. & Ruzzene, M., 1 Jan 2020, In: PLoS ONE. 15, 1, e0227340.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice
Giménez-Llort, L., Santana-Santana, M. & Bayascas, J. R., 8 May 2020, In: Frontiers in Behavioral Neuroscience. 14, 61.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
2018
Reducing the levels of akt activation by PDK1 knock-in mutation protects neuronal cultures against synthetic amyloid-beta peptides
Yang, S., Pascual-Guiral, S., Ponce, R., Giménez-Llort, L., Baltrons, M. A., Arancio, O., Palacio, J. R., Clos, V. M., Yuste, V. J. & Bayascas, J. R., 8 Jan 2018, In: Frontiers in Aging Neuroscience. 9, 435, 435.Research output: Contribution to journal › Article › Research › peer-review
Open Access31 Citations (Scopus)2 Downloads (Pure) -
2016
MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes
Soriano, A., París-Coderch, L., Jubierre, L., Martínez, A., Zhou, X., Piskareva, O., Bray, I., Vidal, I., Almazán-Moga, A., Molist, C., Roma, J., Bayascas, J. R., Casanovas, O., Stallings, R. L., de Toledo, J. S., Gallego, S. & Segura, M. F., 2016, In: Oncotarget. 7, 8, p. 9271-9287 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access31 Citations (Scopus) -
Mutation of the 3-phosphoinositide-dependent protein kinase 1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of akt, leading to impaired cognition and disruptive behaviors
Cordón-Barris, L., Pascual-Guiral, S., Yang, S., Giménez-Llort, L., Lope-Piedrafita, S., Niemeyer, C., Claro, E., Lizcano, J. M. & Bayascas, J. R., 1 Jan 2016, In: Molecular and Cellular Biology. 36, p. 2967-2982Research output: Contribution to journal › Article › Research › peer-review
Open Access25 Citations (Scopus) -
The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase
Erazo, T., Lorente, M., López-Plana, A., Munoz-Guardiola, P., Ferńandez-Nogueira, P., García-Martínez, J. A., Bragado, P., Fuster, G., Salazar, M., Espadaler, J., Hernández-Losa, J., Bayascas, J. R., Cortal, M., Vidal, L., Gascón, P., Gómez-Ferreria, M., Alfón, J., Velasco, G., Doménech, C. & Lizcano, J. M., 15 May 2016, In: Clinical Cancer Research. 22, p. 2508-2519Research output: Contribution to journal › Article › Research › peer-review
55 Citations (Scopus) -
2013
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex
Erazo, T., Moreno, A., Ruiz-Babot, G., Rodríguez-Asiain, A., Morrice, N. A., Espadamala, J., Bayascas, J. R., Gómez, N. & Lizcano, J. M., 1 Apr 2013, In: Molecular and Cellular Biology. 33, p. 1671-1686Research output: Contribution to journal › Article › Research › peer-review
49 Citations (Scopus) -
Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival
Zurashvili, T., Cordón-Barris, L., Ruiz-Babot, G., Zhou, X., Lizcano, J. M., Gómez, N., Giménez-Llort, L. & Bayascas, J. R., 1 Jan 2013, In: Molecular and Cellular Biology. 33, p. 1027-1040Research output: Contribution to journal › Article › Research › peer-review
33 Citations (Scopus) -
Nova descoberta sobre la formació de neurones
Bayascas Ramírez, J. R., 2013, In: UAB Divulga. p. 0001-1 1 p.Research output: Contribution to journal › Article › Dissemination
Open Access -
2011
Brain Specific Kinase-1 BRSK1/SAD-B associates with lipid rafts: Modulation of kinase activity by lipid environment
Translated title of the contribution :Brain Specific Kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment Research output: Contribution to journal › Article › Research › peer-review
20 Citations (Scopus) -
2010
Activation of the cardiac mTOR/p70S6K pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation
Sanchez, C. C., Demeulder, B., Ginion, A., Bayascas, J., Balligand, J., Alessi, D., Vanoverschelde, J., Beauloye, C., Hue, L. & Bertrand, L., 1 Jan 2010, In: Am J Physiol Endocrinol Metab. 298, 4, p. 761-769Research output: Contribution to journal › Article › Research
53 Citations (Scopus) -
PDK1: The major transducer of PI 3-kinase actions
Bayascas, J. R., 1 Dec 2010, In: Current Topics in Microbiology and Immunology. 346, 1, p. 9-29Research output: Contribution to journal › Article › Research › peer-review
90 Citations (Scopus) -
2009
Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
Waugh, C., Sinclair, L., Finlay, D., Bayascas, J. R. & Cantrell, D., 1 Nov 2009, In: Molecular and Cellular Biology. 29, 21, p. 5952-5962Research output: Contribution to journal › Article › Research › peer-review
69 Citations (Scopus) -
2008
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
Bayascas, J. R., Wullschleger, S., Sakamoto, K., García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., 1 Jan 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272Research output: Contribution to journal › Article › Research › peer-review
108 Citations (Scopus) -
2007
The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis
Badiola Benito, N., Bayascas Ramírez, J. R., Rodríguez Álvarez, J., Yuste, V. J., Comella i Carnicé, J. X., Segura, M. F., Solé, C., Pascual Sánchez, M., Moubarak, R. S., Pérez-García, M. J., Gozzelino, R., Iglesias Guimarais, V., Llecha, N. & Soriano García, E., 17 Oct 2007, In: Journal of Neuroscience. 27, 42, p. 11228-11241 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access66 Citations (Scopus) -
2006
Evaluation of approaches to generation of tissue-specific knock-in mice
Bayascas, J., Sakamoto, K., Armit, L., Arthur, J. & Alessi, D., 1 Sept 2006, In: J Biol Chem. 281, 39, p. 28772-28781Research output: Contribution to journal › Article › Research
33 Citations (Scopus) -
LKB1-Dependent Signaling Pathways
Alessi, D., Sakamoto, K. & Bayascas, J., 1 Jan 2006, In: Annu Rev Biochem. 75, p. 137-163Research output: Contribution to journal › Article › Research › peer-review
676 Citations (Scopus) -
2005
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
Bayascas, J., Leslie, N., Parsons, R., Fleming, S. & Alessi, D., 1 Jan 2005, In: Curr Biol. 15, 20, p. 1839-1846Research output: Contribution to journal › Article › Research
136 Citations (Scopus) -
Regulation of Akt/PKB Ser473 phosphorylation
Bayascas, J. & Alessi, D., 1 Jan 2005, In: Molecular Cell. 18, 2, p. 143-145Research output: Contribution to journal › Article › Research › peer-review
147 Citations (Scopus) -
The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis
Yuste, V., Sanchez-Lopez, I., Sole, C., Moubarak, R., Bayascas, J., Dolcet, X., Encinas, M., Susin, S. & Comella, J., 1 Oct 2005, In: J Biol Chem. 280, 42, p. 35670-35683Research output: Contribution to journal › Article › Research › peer-review
Open Access82 Citations (Scopus) -
2004
Characterization of splice variants of human caspase-activated DNase with CIDE-N structure and function
Bayascas, J., Yuste, V., Sole, C., Sanchez-Lopez, I., Segura, M., Perera, R. & Comella, J., 1 Jan 2004, In: FEBS lett.. 566, 1-3, p. 234-240Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signalling
Sole, C., Dolcet, X., Segura, M., Gutierrez, H., Diaz-Meco, M., Gozzelino, R., Sanchis, D., Bayascas, J., Gallego, C., Moscat, J., Davies, A. & Comella, J., 1 Jan 2004, In: J. Cell Biol.. 167, 3, p. 479-492Research output: Contribution to journal › Article › Research
75 Citations (Scopus) -
2002
Isolation of AmphiCASP-3/7, an ancestral caspase from amphioxus (Branchiostoma floridae). Evolutionary considerations for vertebrate caspases
Bayascas, J., Yuste, V., Benito, E., Garcia-Fernàndez, J. & Comella, J., 1 Oct 2002, In: Cell Death & Differentiation. 9, 10, p. 1078-1089Research output: Contribution to journal › Article › Research › peer-review
Open Access36 Citations (Scopus) -
The prevention of staurosporine.induced apoptosis by Bcl-XL, but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells
Yuste, V., Sanchez-Lopez, I., Solé, C., Encinas, M., Bayascas, J., Boix, J. & Comella, J., 1 Jan 2002, In: J Neurochem. 80, 1, p. 126-139Research output: Contribution to journal › Article › Research › peer-review
Open Access63 Citations (Scopus) -
2001
Hox and ParaHox Genes in Flatworms: Characterization and Expression.
Saló, E., Tauler, J., Jimenez, E., Bayascas, J., González-Linares, J., Garcia-Fernandez, J. & Baguñà, J., 1 Jan 2001, In: American Zoologist. 41, p. 652-663Research output: Contribution to journal › Article › Research › peer-review
28 Citations (Scopus) -
The absence of oligonucleosomal DNA fragmentation during apoptosis of IMR-5 neuroblastoma cells. Disappearance of the caspase-activated DNase
Yuste, V. J., Bayascas, J. R., Llecha, N., Sánchez-López, I., Boix, J. & Comella, J. X., 1 Jun 2001, In: J Biol Chem. 276, 25, p. 22323-22331Research output: Contribution to journal › Article › Research › peer-review
Open Access64 Citations (Scopus) -
1999
Bases moleculares de la apoptosis celular y su relacion con la patologia renal
Translated title of the contribution :Molecular bases of cell apoptosis and its relationship with renal diseases Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Bases Moleculares de la apoptosis celular y su relación con la patología renal
Comella JX, L. N. & Bayascas Ramirez, J. R., 1 Jan 1999, In: Nefrologia. 19, Supl. 1, p. 21-28Research output: Contribution to journal › Article › Research
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Hox and ParaHox Genes in Flatworms
Baguñà, J., Saló, E., Tauler, J., Jimenez, E., Bayascas, J. & Garcia-Fernandez, J., 1 Jan 1999, In: American Zoologist. 39, p. 526-Research output: Contribution to journal › Article › Research
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Receptors of the GDNF family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
Soler, R., Dolcet, X., Encinas, M., Egea, J., Bayascas, J. & Comella, J., 1 Nov 1999, In: J.Neurosci. 19, 21, p. 9160-9169Research output: Contribution to journal › Article › Research
158 Citations (Scopus) -
1998
A homeobox gene of the orthodenticle family is involved in antero-posterior patterning of regenerating planarians
Stornaiuolo, A., Bayascas, J., Salo, E. & Boncinelli, E., 1 Nov 1998, In: Int. J. Dev. Biol. 42, 8, p. 1153-1158Research output: Contribution to journal › Article › Research
20 Citations (Scopus) -
Characterization of platyhelminth POU domain genes: ubiquitous and specific anterior nerve cell expression of different epitopes of GtPOU-1
Muñoz-Mármol, A., Casali, A., Miralles, A., Bueno, D., Bayascas, J., Romero, R. & Saló, E., 1 Aug 1998, In: Mechanisms of Development. 76, 1-2, p. 127-140Research output: Contribution to journal › Article › Research
10 Citations (Scopus) -
Platyhelminthes have a Hox code differentially activated during regeneration, with genes closely related to those of spiralian protostomes
Bayascas, J., Castillo, E. & Saló, E., 1 Jan 1998, In: Development Genes and Evolution. 208, 8, p. 467-473Research output: Contribution to journal › Article › Research
45 Citations (Scopus) -
Synchronous and early activation of planarian Hox genes and re-specification of body axes during regeneration.
Translated title of the contribution :Synchronous and early activation of planarian Hox genes and re-specification of body axes during regeneration. Research output: Contribution to journal › Article › Research
6 Citations (Scopus) -
1997
New protocol to visualize gene expression in intact and regenerating adult planarians by whole mount in situ hibridization
Bueno, D., Castillo, E., Vispo, M., Cebrià, F., Bayascas, J., Saló, E. & Romero, R., 1 Jan 1997, In: Elsevier Trends Journal Technical Tips Online. p. 1-1Research output: Contribution to journal › Article › Research › peer-review
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Planarian homeobox gene Dtprd-1 is expressed in specific gland cells, and belongs to a new family within the paired-like class
Muñoz-Mármol, A., Bayascas, J. R., Castillo, E., Casali, A. & Saló, E., 1 Jan 1997, In: Development Genes and Evolution. 207, 5, p. 296-305Research output: Contribution to journal › Article › Research
8 Citations (Scopus) -
Planarian Hox genes: novel patterns of expression during regeneration.
Bayascas, J., Castillo, E., Muñoz-Mármol, A. & Saló, E., 1 Jan 1997, In: Development (Cambridge). 124, 1, p. 141-148Research output: Contribution to journal › Article › Research
66 Citations (Scopus) -
1996
Hox genes disobey colinearity and do not distinguish head from tail during planarian regeneration.
Bayascas, J., Castillo, E., Muñoz-Mármol, A. & Saló, E., 1 Jan 1996, In: Int. J. Dev. Biol. SUPPL 1, p. 173S-174SResearch output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
1995
High copy number of highly conserved mariner-like transposons in planarian (Platyhelminthe): Evidence for a trans-phyla horizontal transfer.
Garcia-Fernàndez, J., Bayascas-Ramírez, J., Marfany, G., Muñoz-Mármol, A., Casali, A., Baguñà, J. & Saló, E., 1 Jan 1995, In: Mol. Biol. Evol. 12, 3, p. 421-431Research output: Contribution to journal › Article › Research
90 Citations (Scopus) -
The freshwater planarian Dugesia(G)tigrina contains a great diversity of homeobox genes.
Translated title of the contribution :The freshwater planarian Dugesia(G)tigrina contains a great diversity of homeobox genes. Research output: Contribution to journal › Article › Research
7 Citations (Scopus) -
1994
Regeneration and pattern formation in planarians: Cells, molecules and genes.
Baguñà, J., Saló, E., Romero, R., Garcia-Fernàndez, J., Bueno, D., Muñoz-Mármol, A., Bayascas-Ramírez, J. & Casali, A., 1 Jan 1994, In: Zool. Sci. 11, 6, p. 781-795Research output: Contribution to journal › Article › Research › peer-review
82 Citations (Scopus)