1. Identification of the high affinity receptors of the clostridial neurotoxins, their subcellular localization and their dynamic association with the cholesterol- and sphingolipid-enriched lipid domains (lipid rafts).
2. Structural and compositional characterization of lipid rafts in different neuronal models and of their role in different events of the neuronal physiology.
3. Determination of the pharmacological kinetics of the Hc-TeTx fragment as a proserotoninergic agent.
4. Determination of the neuroprotective capacity of the Hc-TeTx in degenerative processes associated with mental diseases.
5. Characterization of the neurotrophic action conducted by the Hc-TeTx fragment: evaluation of its therapeutic capacity in the treatment of neurodegenerative diseases.
h-index
1198
Citations
22
h-index
Calculated based on number of publications stored in Pure and citations from Scopus
1985 …2023
Research activity per year
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