Jose Aguilera Avila

Phone34-93-581 3861, 34-93-581 1573, 93 581 1525, 93 581 1573

Edifici M planta 1ª torre M1
08193 Bellaterra (Cerdanyola del Vallès)
Edifici M, Campus UAB
08193 Bellaterra (Cerdanyola del Vallès)

Accepting PhD Students

PhD projects

1. Identification of the high affinity receptors of the clostridial neurotoxins, their subcellular localization and their dynamic association with the cholesterol- and sphingolipid-enriched lipid domains (lipid rafts). 2. Structural and compositional characterization of lipid rafts in different neuronal models and of their role in different events of the neuronal physiology. 3. Determination of the pharmacological kinetics of the Hc-TeTx fragment as a proserotoninergic agent. 4. Determination of the neuroprotective capacity of the Hc-TeTx in degenerative processes associated with mental diseases. 5. Characterization of the neurotrophic action conducted by the Hc-TeTx fragment: evaluation of its therapeutic capacity in the treatment of neurodegenerative diseases.

Source: Scopus
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Personal profile

Research interests

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Education/Academic qualification

Ph. D., Universitat Autònoma de Barcelona (UAB)

Award Date: 12 Feb 1985

Degree, Universitat Autònoma de Barcelona (UAB)

Award Date: 1 Jun 1977

External positions

Vicerector de Personal d'Aministració i Serveis, Universitat Autònoma de Barcelona (UAB)

6 Jun 2016 → 13 Nov 2020

Director, Institut de Neurociències (INC_UAB)

16 Nov 2009 → 31 Jan 2016

Director

16 May 2002 → 14 Sep 2008

Cap d'Unitat

20 Oct 1997 → 14 Mar 2002

Profesor Titular de Universidad (interino), Universitat Autònoma de Barcelona (UAB)

15 Sep 1991 → 27 Dec 1992

Ayudante de Facultad (Y2), Universitat Autònoma de Barcelona (UAB)

1 Oct 1989 → 14 Sep 1991

Ayudante de Escuela Universitaria (Y3), Universitat Autònoma de Barcelona (UAB)

1 Oct 1987 → 30 Sep 1989

Ayudante Clases Práct. Contratado, Universitat Autònoma de Barcelona (UAB)

1 Oct 1978 → 30 Sep 1987

Becario (CAICYT PG ref. 1696), Universitat Autònoma de Barcelona (UAB)

1 Jan 1978 → 30 Sep 1978

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2 Active
13 Finished

SYNAPTIC INTERACTOME AND TRANSCRIPTOME OF THE SYNAPTONUCLEAR FACTOR CRTC1 IN ALZHEIMER DISEASE TRANSGENIC MICE
Saura Antolin, C. A., CAPILLA LOPEZ, M. D., Deprada Fernandez, A., Ser Badia, A. D., Soto Faguas, C. M. & Aguilera Avila, J.
1/06/20 → 31/05/23
Project
CIBERNED_Patología neuromuscular clínica y experimental
Navarro Acebes, X., Aguilera Avila, J., Cuadras Mas, J., Rodriguez Alvarez, J., Hernández Martín, J., Bosch Merino, M. A., Jaramillo Rodríguez, J., Casas Louzao, C., Candalija Iserte, A. M., Coll Miro, M., Oliva Muñoz, N. D. L., Arbat Plana, A., Martínez Muriana, A., Siedlecki Wullich, D. J., Catala Solsona, J., Santos Rojas, D. H., Cobianchi , S., Francos Quijorna, I., González Pérez, F. J., Del Valle Macia, J., Romeo Guitart, D., López Serrano, C., Enriquez Barreto, L., López Álvarez, V. M., Modol Caballero, G., Bruna Escuer, J., Udina Bonet, E., Herrando Grabulosa, M., Lopez Vales, R., Morell Orduña, M. & Torres Espín, A.
1/01/08 → 31/12/30
Project
Mecanismos transcripcionales de plasticidad sináptica en circuitos de memoria en un modelo murino de neurodegeneracion
Saura Antolin, C. A. & Aguilera Avila, J.
30/12/16 → 29/05/20
Project
MECANISMOS TRANSCRIPCIONALES DE PERDIDA DE MEMORIA EN RATONES TRANSGENICOS DE LA ENFERMEDAD DE ALZHEIMER
Saura Antolin, C. A., CANDALIJA ISERTE, A., Aguilera Avila, J. & Enriquez Barreto, L.
1/01/14 → 31/12/16
Project
Demostrar la acción neurotrófica del fragmento no tóxico C terminal de la toxina tetánica y su capacidad terapéutica en la enfermedad de Parkinson y en otras enfermedades neurodegenerativas
Aguilera Avila, J., Herrando Grabulosa, M., Cubí Piqué, R. & Gil Giro, C.
1/01/10 → 31/12/12
Project

930 Citations
20 h-Index
60 Article
11 Chapter
4 Patent
1 Literature review

C-terminal fragment of tetanus toxin (Hc) for treatment of depression
Aguilera, J. & Tizabi, Y., 2020, Patent No. 16/878,809 (EEUU), (2020)
Research output: Patent
Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model
Martínez, L. M., Torre, M. D. L., Muñoz, M. J., Zaragoza, P., Aguilera, J., Calvo, A. C. & Osta, R., May 2020, In: Toxins. 12, 330, p. 1-10 10 p., 12.
Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)
Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease.
Herrando Grabulosa, M., Casas Louzao, C., Talbot, K. & Aguilera, J., 21 Oct 2020, In: Toxins. 12, 10, p. 666-675 11 p., 12.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
The C-terminal fragment of the heavy chain of the tetanus toxin (Hc-TeTx) improves motor activity and neuronal morphology in the limbic system of aged mice.
Vazquez-Roque, R., Aguilera, J., Pacheco-Flores, M., Penagos-Corzo, JC., Flores, G., Treviño, S., Guevara, J., Diaz, A. & Venegas, B., 2020, In: Synapse. p. 22193 2.
Research output: Contribution to journal › Article › Research › peer-review
Antidepressant effects of C-terminal domain of the heavy chain of tetanus toxin in a rat model of depression
Getachew, B., Mendieta, L., Csoka, A. B., Aguilera, J. & Tizabi, Y., 16 Sep 2019, In: Behavioural Brain Research. 370, p. 111968 5 p., 111968.
Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus)