Jose Aguilera Avila

Accepting PhD Students

PhD projects

1. Identification of the high affinity receptors of the clostridial neurotoxins, their subcellular localization and their dynamic association with the cholesterol- and sphingolipid-enriched lipid domains (lipid rafts).

2. Structural and compositional characterization of lipid rafts in different neuronal models and of their role in different events of the neuronal physiology.

3. Determination of the pharmacological kinetics of the Hc-TeTx fragment as a proserotoninergic agent.

4. Determination of the neuroprotective capacity of the Hc-TeTx in degenerative processes associated with mental diseases.

5. Characterization of the neurotrophic action conducted by the Hc-TeTx fragment: evaluation of its therapeutic capacity in the treatment of neurodegenerative diseases.

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Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

Education/Academic qualification

Ph. D., Doctor en ciencias biológicas, Universitat Autònoma de Barcelona (UAB)

Award Date: 12 Feb 1985

Degree, Ciencias (Sección Biológicas), Universitat Autònoma de Barcelona (UAB)

Award Date: 1 Jun 1977

External positions

Vicerector de Personal d'Aministració i Serveis, Universitat Autònoma de Barcelona (UAB)

6 Jun 2016 → 13 Nov 2020

Director, Institute of Neuroscience (INc)c)

16 Nov 2009 → 31 Jan 2016

Director, Departament de Bioquímica i Biologia Molecular UAB

16 May 2002 → 14 Sept 2008

Cap d'Unitat, Departament de Bioquímica i Biologia Molecular UAB

20 Oct 1997 → 14 Mar 2002

Profesor Titular de Universidad (interino), Universitat Autònoma de Barcelona (UAB)

15 Sept 1991 → 27 Dec 1992

Ayudante de Facultad (Y2), Universitat Autònoma de Barcelona (UAB)

1 Oct 1989 → 14 Sept 1991

Ayudante de Escuela Universitaria (Y3), Universitat Autònoma de Barcelona (UAB)

1 Oct 1987 → 30 Sept 1989

Ayudante Clases Práct. Contratado, Universitat Autònoma de Barcelona (UAB)

1 Oct 1978 → 30 Sept 1987

Becario (CAICYT PG ref. 1696), Universitat Autònoma de Barcelona (UAB)

1 Jan 1978 → 30 Sept 1978

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1 Similar Profiles

3 Active
14 Finished

TRANSCRIPTIONAL ANALYSIS AND FUNCTIONAL MODULATION OF MEMORY NEURAL CIRCUITS IN ALZHEIMERS DISEASE
Saura Antolin, C. A. (Principal Investigator), Capilla Lopez, M. D. (Collaborator), Delprat Obeaga, M. A. (Collaborator), Deprada Fernandez, A. (Collaborator), Fernandez Olalla, X. (Collaborator), Parra Damas, A. J. (Collaborator), Aguilera Avila, J. (Investigator) & Sotillo Sotillo, P. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
Modulación terapéutica del epitranscriptoma neuronal en demencia
Fernandez Olalla, X. (Collaborator), Parra Damas, A. J. (Investigator), Aguilera Avila, J. (Investigator), Saura Antolin, C. A. (Principal Investigator), Delprat Obeaga, M. A. (Collaborator) & Martin Pinardi, L. (Collaborator)
1/12/22 → 31/08/25
Project: Research Projects and Other Grants
CIBERNED_Patología neuromuscular clínica y experimental
Navarro Acebes, X. (Principal Investigator), Aguilera Avila, J. (Investigator), Arbat Plana, A. (Investigator), Bosch, A. (Investigator), Bruna Escuer, J. (Investigator), Candalija Iserte, A. M. (Investigator), Casas, C. (Investigator), Catala Solsona, J. (Investigator), Cobianchi , S. (Investigator), Coll Miro, M. (Investigator), Cuadras Mas, J. (Investigator), Del Valle Macia, J. (Investigator), Enriquez Barreto, L. (Investigator), Francos Quijorna, I. (Investigator), González Pérez, F. J. (Investigator), Hernández Martín, J. (Investigator), Herrando Grabulosa, M. (Investigator), Jaramillo Rodríguez, J. (Investigator), Lopez Vales, R. (Investigator), López Serrano, C. (Investigator), López Álvarez, V. M. (Investigator), Martínez Muriana, A. (Investigator), Modol Caballero, G. (Investigator), Morell Orduña, M. (Investigator), Oliva Muñoz, N. D. L. (Investigator), Rodriguez Alvarez, J. (Investigator), Romeo Guitart, D. (Investigator), Santos Rojas, D. H. (Investigator), Siedlecki Wullich, D. J. (Investigator), Torres Espín, A. (Investigator), Udina Bonet, E. (Investigator), Garcia Garcia, J. (Investigator), Lopez Santos, D. (Investigator) & Badia Puiggali, C. (Investigator)
1/01/08 → 31/12/30
Project: Research Projects and Other Grants
SYNAPTIC INTERACTOME AND TRANSCRIPTOME OF THE SYNAPTONUCLEAR FACTOR CRTC1 IN ALZHEIMER DISEASE TRANSGENIC MICE
Saura Antolin, C. A. (Principal Investigator), Capilla Lopez, M. D. (Collaborator), Deprada Fernandez, A. (Collaborator), Ser Badia, A. D. (Collaborator), Soto Faguas, C. M. (Collaborator), Aguilera Avila, J. (Investigator), Fernandez Gonzalez, I. (Collaborator) & Fernandez Olalla, X. (Investigator)
1/06/20 → 31/05/23
Project: Research Projects and Other Grants
Mecanismos transcripcionales de plasticidad sináptica en circuitos de memoria en un modelo murino de neurodegeneracion
Saura Antolin, C. A. (Principal Investigator), Aguilera Avila, J. (Investigator) & Capilla Lopez, M. D. (Collaborator)
Spanish Ministry of Economy and Competitiveness (MINECO)
30/12/16 → 31/12/20
Project: Research Projects and Other Grants

64 Article
11 Chapter
4 Patent
1 Literature review

Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats
Patricio, F., Morales Dávila, E., Patricio-Martínez, A., Arana Del Carmen, N., Martínez, I., Aguilera, J., Perez-Aguilar, J. M. & Limón, I. D., 2022, In: Frontiers in Pharmacology. 13
Research output: Contribution to journal › Article › Research › peer-review

Open Access
7 Citations (Scopus)
The C-terminal domain of the heavy chain of tetanus toxin prevents the oxidative and nitrosative stress induced by acute toxicity of 1-methyl-4-phenylpyridinium, a rat model of Parkinson's disease
Patricio Martinez, F., JUÁREZ TORRES, D., Patricio Martínez, A., Mendieta, L., Pérez Severiano, F., Montes, S., Aguilera, J. & Limón, I. D., Jan 2022, In: Neuroscience Research. 174, p. 36-45 10 p., 174.
Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin
Candalija, A., Scior, T., Rackwitz, H.-R., Ruiz-Castelan, J. E., Martinez-Laguna, Y. & Aguilera, J., 1 Jul 2021, In: Molecules. 26, 13, 23 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
1 Citation (Scopus)
C-terminal fragment of tetanus toxin (Hc) for treatment of depression
Aguilera, J. (Inventor) & Tizabi, Y. (Inventor), 2020, Patent No. 16/878,809 (EEUU), (2020)
Research output: Patent
Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model
Martínez, L. M., Torre, M. D. L., Muñoz, M. J., Zaragoza, P., Aguilera, J., Calvo, A. C. & Osta, R., May 2020, In: Toxins. 12, 5, p. 1-10 10 p., 12.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
9 Citations (Scopus)

Acción de la toxina tetánica en el SNC de los mamíferos: efecto sobre el sistema serotoninérgico
Aguilera Ávila, J. (Author), González Sastre, F. (Director), 1 Jan 1984
Student thesis: Doctoral thesis

Jose Aguilera Avila

Personal profile

Research interests

Expertise related to UN Sustainable Development Goals

Education/Academic qualification

External positions

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

TRANSCRIPTIONAL ANALYSIS AND FUNCTIONAL MODULATION OF MEMORY NEURAL CIRCUITS IN ALZHEIMERS DISEASE

Modulación terapéutica del epitranscriptoma neuronal en demencia

CIBERNED_Patología neuromuscular clínica y experimental

SYNAPTIC INTERACTOME AND TRANSCRIPTOME OF THE SYNAPTONUCLEAR FACTOR CRTC1 IN ALZHEIMER DISEASE TRANSGENIC MICE

Mecanismos transcripcionales de plasticidad sináptica en circuitos de memoria en un modelo murino de neurodegeneracion

Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats

The C-terminal domain of the heavy chain of tetanus toxin prevents the oxidative and nitrosative stress induced by acute toxicity of 1-methyl-4-phenylpyridinium, a rat model of Parkinson's disease

Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin

C-terminal fragment of tetanus toxin (Hc) for treatment of depression

Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model

Acción de la toxina tetánica en el SNC de los mamíferos: efecto sobre el sistema serotoninérgico

Jose Aguilera Avila

Personal profile

Research interests

Expertise related to UN Sustainable Development Goals

Education/Academic qualification

External positions

Fingerprint

Collaborations and top research areas from the last five years

Projects

Research output

Thesis