Francisco Javier Carrasco Trancoso

2017

Influence of transgenic metallothionein-1 on gliosis, ca1 neuronal loss, and brain metal levels of the tg2576 mouse model of alzheimer’s disease

Comes, G., Manso, Y., Escrig, A., Fernandez-Gayol, O., Sanchis, P., Molinero, A., Giralt, M., Carrasco, J. & Hidalgo, J., 1 Feb 2017, In: International Journal of Molecular Sciences. 18, 2, 251.

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

2016

Chlorella vulgaris reduces the impact of stress on hypothalamic-pituitary-adrenal axis and brain c-fos expression

Souza Queiroz, J., Marín Blasco, I., Gagliano, H., Daviu, N., Gómez Román, A., Belda, X., Carrasco, J., Rocha, M. C., Palermo Neto, J. & Armario, A., 1 Mar 2016, In: Psychoneuroendocrinology. 65, p. 1-8

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease

Manso, Y., Comes, G., López-Ramos, J. C., Belfiore, M., Molinero, A., Giralt, M., Carrasco, J., Adlard, P. A., Bush, A. I., Delgado-García, J. M. & Hidalgo, J., 27 Feb 2016, In: Journal of Alzheimer's Disease. 51, 1, p. 81-95

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

2015

Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress

Rabasa, C., Pastor-Ciurana, J., Delgado-Morales, R., Gómez-Román, A., Carrasco, J., Gagliano, H., García-Gutiérrez, M. S., Manzanares, J. & Armario, A., 1 Aug 2015, In: European Neuropsychopharmacology. 25, 8, p. 1248-1259

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Muscular interleukin-6 differentially regulates skeletal muscle adaptation to high-fat diet in a sex-dependent manner

Guerra, J., Ferrer, B., Giralt, M., Comes, G., Carrasco, J., Molinero, A., Serrano, A. L. & Hidalgo, J., 1 Jul 2015, In: Cytokine. 74, p. 145-151

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

2014

Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary-adrenal (HPA) axis

Lago, N., Quintana, A., Carrasco, J., Giralt, M., Hidalgo, J. & Molinero, A., 1 Jan 2014, In: Neurochemistry International. 74, p. 65-73

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats

Fuentes, S., Carrasco, J., Armario, A. & Nadal, R., 1 Jan 2014, In: Hormones and Behavior. 66, p. 475-486

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Interleukin-6 deletion in mice driven by aP2-Cre-ERT2 prevents against high-fat diet-induced gain weight and adiposity in female mice

Navia, B., Ferrer, B., Giralt, M., Comes, G., Carrasco, J., Molinero, A., Quintana, A., Leclerc, J., Viollet, B., Señarís, R. M. & Hidalgo, J., 1 Jan 2014, In: Acta Physiologica. 211, 4, p. 585-596

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner

Ferrer, B., Navia, B., Giralt, M., Comes, G., Carrasco, J., Molinero, A., Quintana, A., Señarís, R. M. & Hidalgo, J., 1 Jan 2014, In: Brain, Behavior, and Immunity. 40, p. 121-130

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

2013

Emotional responses to a negative emotion induction procedure in borderline personality disorder

Feliu-Soler, A., Pascual, J. C., Soler, J., Pérez, V., Armario, A., Carrasco, J., Sanz, A., Villamarín, F. & Borràs, X., 1 Jan 2013, In: International Journal of Clinical and Health Psychology. 13, 1, p. 9-17

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

2012

Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease

Manso, Y., Carrasco, J., Comes, G., Meloni, G., Adlard, P. A., Bush, A. I., Vašák, M. & Hidalgo, J., 1 Nov 2012, In: Cellular and Molecular Life Sciences. 69, p. 3683-3700

Research output: Contribution to journal › Article › Research › peer-review

40 Citations (Scopus)

Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease

Manso, Y., Carrasco, J., Comes, G., Adlard, P. A., Bush, A. I. & Hidalgo, J., 1 Nov 2012, In: Cellular and Molecular Life Sciences. 69, p. 3665-3681

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

2010

The comparison of mouse full metallothionein-1 versus α and β domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs

Manso, Y., Serra, M., Comes, G., Giralt, M., Carrasco, J., Cols, N., Vašák, M., González-Duarte, P. & Hidalgo, J., 1 Jun 2010, In: Journal of Neuroscience Research. 88, p. 1708-1718

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

2008

Characterization of central and peripheral components of the hypothalamus-pituitary-adrenal axis in the inbred Roman rat strains

Carrasco, J., Márquez, C., Nadal, R., Tobeña, A., Fernández-Teruel, A. & Armario, A., 1 Jan 2008, In: Psychoneuroendocrinology. 33, 4, p. 437-445

Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)

Redefining the role of metallothionein within the injured brain: Extracellular metallothioneins play an important role in the astrocyte-neuron response to injury

Chung, R. S., Penkowa, M., Dittmann, J., King, C. E., Bartlett, C., Asmussen, J. W., Hidalgo, J., Carrasco, J., Leung, Y. K. J., Walker, A. K., Fung, S. J., Dunlop, S. A., Fitzgerald, M., Beazley, L. D., Chuah, M. I., Vickers, J. C. & West, A. K., 30 May 2008, In: Journal of Biological Chemistry. 283, p. 15349-15358

Research output: Contribution to journal › Article › Research › peer-review

Open Access

131 Citations (Scopus)

2005

Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: A microarray analysis

Poulsen, C. B., Penkowa, M., Borup, R., Nielsen, F. C., Cáceres, M., Quintana, A., Molinero, A., Carrasco, J., Giralt, M. & Hidalgo, J., 1 Jan 2005, In: Journal of Neurochemistry. 92, p. 417-432

Research output: Contribution to journal › Article › Research › peer-review

Open Access

43 Citations (Scopus)

The effects of chronic food restriction on hypothalamic-pituitary-adrenal activity depend on morning versus evening availability of food

Belda, X., Ons, S., Carrasco, J. & Armario, A., 1 May 2005, In: Pharmacology Biochemistry and Behavior. 81, 1, p. 41-46

Research output: Contribution to journal › Article › Research › peer-review

29 Citations (Scopus)

2004

Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide

Penkowa, M., Quintana, A., Carrasco, J., Giralt, M., Molinero, A. & Hidalgo, J., 1 Jul 2004, In: Journal of Neuroscience Research. 77, p. 35-53

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

2003

Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury

Penkowa, M., Giralt, M., Lago, N., Camats, J., Carrasco, J., Hernández, J., Molinero, A., Campbell, I. L. & Hidalgo, J., 1 Jun 2003, In: Experimental Neurology. 181, p. 130-148

Research output: Contribution to journal › Article › Research › peer-review

121 Citations (Scopus)

Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte - Targeted interleukin-6 expression

Penkowa, M., Camats, J., Giralt, M., Molinero, A., Hernández, J., Carrasco, J., Campbell, I. L. & Hidalgo, J., 1 May 2003, In: GLIA. 42, p. 287-306

Research output: Contribution to journal › Article › Research › peer-review

40 Citations (Scopus)

Role of metallothionein-III following central nervous system damage

Carrasco, J., Penkowa, M., Giralt, M., Camats, J., Molinero, A., Campbell, I. L., Palmiter, R. D. & Hidalgo, J., 1 Jan 2003, In: Neurobiology of Disease. 13, p. 22-36

Research output: Contribution to journal › Article › Research › peer-review

50 Citations (Scopus)

Role of metallothioneins in peripheral nerve function and regeneration

Ceballos, D., Lago, N., Verdú, E., Penkowa, M., Carrasco, J., Navarro, X., Palmiter, R. D. & Hidalgo, J., 1 Jan 2003, In: Cellular and Molecular Life Sciences. 60, p. 1258-1266

Research output: Contribution to journal › Article › Research

47 Citations (Scopus)

2002

Evidence that metyrapone can act as a stressor: Effect on pituitary-adrenal hormones, plasma glucose and brain c-fos induction

Rotllant, D., Ons, S., Carrasco, J. & Armario, A., 31 Dec 2002, In: European Journal of Neuroscience. 16, p. 693-700

Research output: Contribution to journal › Article › Research › peer-review

55 Citations (Scopus)

M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment

Penkowa, M., Poulsen, C. B., Carrasco, J. & Hidalgo, J., 1 Jan 2002, In: Experimental Neurology. 176, p. 308-321

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6

Giralt, M., Penkowa, M., Hernández, J., Molinero, A., Carrasco, J., Lago, N., Camats, J., Campbell, I. L. & Hidalgo, J., 1 Jan 2002, In: Neurobiology of Disease. 9, p. 319-338

Research output: Contribution to journal › Article › Research › peer-review

58 Citations (Scopus)

2001

Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis

Espejo, C., Carrasco, J., Hidalgo, J., Penkowa, M., Garcia, A., Sáez-Torres, I. & Martínez-Cáceres, E. M., 22 Aug 2001, In: Neuroscience. 105, p. 1055-1065

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures

Penkowa, M., Molinero, A., Carrasco, J. & Hidalgo, J., 14 Feb 2001, In: Neuroscience. 102, p. 805-818

Research output: Contribution to journal › Article › Research › peer-review

132 Citations (Scopus)

Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes

Penkowa, M., Giralt, M., Thomsen, P. S., Carrasco, J. & Hidalgo, J., 1 Jan 2001, In: Journal of Neurotrauma. 18, p. 447-463

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

2000

Altered central nervous system cytokine-growth factor expression profiles and angiogenesis in metallothionein-I+II deficient mice

Penkowa, M., Carrasco, J., Giralt, M., Molinero, A., Hernández, J., Campbell, I. L. & Hidalgo, J., 1 Jan 2000, In: Journal of Cerebral Blood Flow and Metabolism. 20, 8, p. 1174-1189

Research output: Contribution to journal › Article › Research › peer-review

Open Access

87 Citations (Scopus)

Effect of dietary zinc deficiency on brain metallothionein-I and -III mRNA levels during stress and inflammation

Giralt, M., Molinero, A., Carrasco, J. & Hidalgo, J., 1 Jan 2000, In: Neurochemistry International. 36, p. 555-562

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I plus II-deficient mice

Carrasco, J., Penkowa, M., Hadberg, H., Molinero, A. & Hidalgo, J., 1 Jan 2000, In: Eur J Neurosci. 12, 7, p. 2311-2322

Research output: Contribution to journal › Article › Research

125 Citations (Scopus)

Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice

Penkowa, M., Giralt, M., Carrasco, J., Hadberg, H. & Hidalgo, J., 16 Dec 2000, In: GLIA. 32, 3, p. 271-285

Research output: Contribution to journal › Article › Research › peer-review

141 Citations (Scopus)

Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons

Montoliu, C., Monfort, P., Carrasco, J., Palacios, Ò., Capdevila, M., Hidalgo, J. & Felipo, V., 11 Jul 2000, In: Journal of Neurochemistry. 75, 1, p. 266-273

Research output: Contribution to journal › Article › Research › peer-review

61 Citations (Scopus)

Metallothionein induction by restraint stress: Role of glucocorticoids and IL-6

Hernández, J., Carrasco, J., Belloso, E., Giralt, M., Bluethmann, H., Kee Lee, D., Andrews, G. K. & Hidalgo, J., 1 Jan 2000, In: Cytokine. 12, p. 791-796

Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)

Metallothioneins are upregulated in symptomatic mice with astrocyte- targeted expression of tumor necrosis factor-α

Carrasco, J., Giralt, M., Penkowa, M., Stalder, A. K., Campbell, I. L. & Hidalgo, J., 1 Jan 2000, In: Experimental Neurology. 163, p. 46-54

Research output: Contribution to journal › Article › Research › peer-review

Open Access

35 Citations (Scopus)

1999

Liver and brain metallothionein regulation in transgenic mice overexpressiong interleukin-6 and in mice carrying a null mutation in the interleukin-6 gene

Hidalgo, J., Carrasco, J., Hernandez, J., Giralt, M., Molinero, A., Gonzalez, B., Bluethmann, H. & Campbell, IL., 1 Jan 1999, Metallothionein IV. - ed. Basilea (CH), p. 363-370 7 p.

Research output: Chapter in Book › Chapter › Research

1998