Research output per year
Research output per year
- 1 - 50 out of 78 results
Search results
-
2023
Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure
Roig-Soriano, J., Sánchez-de-Diego, C., Esandi-Jauregui, J., Verdés, S., Abraham, C. R., Bosch i Merino, A., Ventura, F. & Chillón Rodríguez, M., 14 Mar 2023, In: Scientific Reports. 13, 10 p., 4211.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
2022
AAV-mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
Roig-Soriano, J., Griñán-Ferré, C., Espinosa-Parrilla, J. F., Abraham, C. R., Bosch, A., Pallàs, M. & Chillón, M., Apr 2022, In: Aging Cell. 21, 4, 15 p., e13581.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis
Edo, Á., Calvo-Barreiro, L., Eixarch, H., Bosch, A., Chillón, M. & Espejo, C., Sept 2022, In: Neurotherapeutics. 19, 5, p. 1617-1633 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
2021
A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy
Rubinstein, T. A., Reuveni, I., Hesin, A., Klein-Goldberg, A., Olauson, H., Larsson, T. E., Abraham, C. R., Zeldich, E., Bosch, A., Chillón, M., Hollander, K. S., Shabtay-Orbach, A., Vainer, G. W., Wolf, I. & Rubinek, T., 15 Dec 2021, In: Cancers. 13, 24, 13 p., 6297.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)1 Downloads (Pure) -
Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery
Bosch Merino, M. A., Dec 2021, In: SCIENTIFIC REPORTS.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1 G93AALS Mice.
Mòdol-Caballero, G., Herrando-Grabulosa, M., Verdés, S., García-Lareu, B., Hernández, N., Francos-Quijorna, I., López-Vales, R., Bosch, A. & Navarro, X., 22 Sept 2021, In: Frontiers in Neurology.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus)2 Downloads (Pure) -
GRP78 Overexpression Triggers PINK1-IP3R-Mediated Neuroprotective Mitophagy
Leiva-Rodríguez, T., Romeo-Guitart, D., Herrando-Grabulosa, M., Bosch, A. & Lizcano de Vega, J. M., 18 Aug 2021, In: Biomedicines. 9, 8Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy
Bosch, A. & Estévez, R., 22 Jan 2021, In: Frontiers in Cellular Neuroscience. 14, 627887.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus) -
PROTEOMIC QUANTITATIVE STUDY OF DORSAL ROOT GANGLIA AND SCIATIC NERVE IN TYPE 2 DIABETIC MICE.
Bosch Merino, M. A., 29 Nov 2021, In: Molecular Metabolism.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis
Mòdol-Caballero, G., García-Lareu, B., Herrando-Grabulosa, M., Verdés, S., López-Vales, R., Pagès, G., Chillón, M., Navarro, X. & Bosch, A., 30 Mar 2021, In: Neurotherapeutics. 18, 2, 14 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)1 Downloads (Pure) -
2020
Cerebellar Astrocyte Transduction as Gene Therapy for Megalencephalic Leukoencephalopathy
Sánchez, A., García-Lareu, B., Puig, M., Prat, E., Ruberte, J., Chillón, M., Nunes, V., Estévez, R. & Bosch, A., Oct 2020, In: Neurotherapeutics. 17, 4, p. 2041-2053 13 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice
Mòdol-Caballero, G., Herrando-Grabulosa, M., García-Lareu, B., Solanes, N., Verdés, S., Osta, R., Francos-Quijorna, I., López-Vales, R., Calvo, A. C., Bosch, A. & Navarro, X., 1 Apr 2020, In: Neurobiology of disease. 137, p. 104793 10 p., 104793.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus)1 Downloads (Pure) -
Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis
Mòdol-Caballero, G., García-Lareu, B., Verdés, S., Ariza, L., Sánchez-Brualla, I., Brocard, F., Bosch, A., Navarro, X. & Herrando-Grabulosa, M., 1 Jul 2020, In: Neurotherapeutics. 17, 3, p. 1048-1060 13 p.Research output: Contribution to journal › Article › Research › peer-review
16 Citations (Scopus) -
2019
Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
Lopez-Font, I., Sogorb-Esteve, A., Javier-Torrent, M., Brinkmalm, G., Herrando-Grabulosa, M., García-Lareu, B., Turon-Sans, J., Rojas-García, R., Lleó, A., Saura, C. A., Zetterberg, H., Blennow, K., Bosch, A., Navarro, X. & Sáez-Valero, J., 1 Apr 2019, In: Neurobiology of Disease. 124, p. 428-438Research output: Contribution to journal › Article › Research
12 Citations (Scopus) -
Intrathecal AAVrh10 corrects biochemical and histological hallmarks of mucopolysaccharidosis VII mice and improves behavior and survival
Pagès, G., Giménez-Llort, L., García-Lareu, B., Ariza, L., Navarro, M., Casas Louzao, C., Chillón, M. & Bosch, A., 1 Nov 2019, In: Human Molecular Genetics. 28, 21, p. 3610-3624Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
2018
ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-Trafficking alterations in axotomized motoneurons article
Leiva-Rodríguez, T., Romeo-Guitart, D., Marmolejo-Martínez-Artesero, S., Herrando-Grabulosa, M., Bosch, A., Forés, J. & Casas, C., 1 Jun 2018, In: Cell death and disease. 9, 6, 626.Research output: Contribution to journal › Article › Research › peer-review
16 Citations (Scopus) -
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons
Bayó-Puxan, N., Terrasso, A. P., Creyssels, S., Simão, D., Begon-Pescia, C., Lavigne, M., Salinas, S., Bernex, F., Bosch, A., Kalatzis, V., Levade, T., Cuervo, A. M., Lory, P., Consiglio, A., Brito, C. & Kremer, E. J., 1 Dec 2018, In: SCIENTIFIC REPORTS. 8, 16644.Research output: Contribution to journal › Article › Research › peer-review
15 Citations (Scopus) -
Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence
Romeo-Guitart, D., Forés, J., Herrando-Grabulosa, M., Valls, R., Leiva-Rodríguez, T., Galea, E., González-Pérez, F., Navarro, X., Petegnief, V., Bosch, A., Coma, M., Mas, J. M. & Casas, C., 1 Dec 2018, In: Scientific Reports. 8, 1, 1879.Research output: Contribution to journal › Article › Research
Open Access56 Citations (Scopus) -
Secreted αKlotho isoform protects against age-dependent memory deficits
Massó, A., Sánchez, A., Bosch, A., Giménez-Llort, L. & Chillón, M., 1 Sept 2018, In: Molecular Psychiatry. 23, 9Research output: Contribution to journal › Article › Research › peer-review
41 Citations (Scopus) -
2017
Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor
Miralles, M., Eixarch, H., Tejero, M., Costa, C., Hirota, K., Castaño, A. R., Puig, M., Stockinger, G., Montalban, X., Bosch, A., Espejo, C. & Chillon, M., 1 Oct 2017, In: Neurotherapeutics. 14, 4, p. 1095-1106 12 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
2016
Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation
Mancuso, R., Martínez-Muriana, A., Leiva, T., Gregorio, D., Ariza, L., Morell, M., Esteban-Pérez, J., García-Redondo, A., Calvo, A. C., Atencia-Cibreiro, G., Corfas, G., Osta, R., Bosch, A. & Navarro, X., 1 Nov 2016, In: Neurobiology of Disease. 95, p. 168-178Research output: Contribution to journal › Article › Research › peer-review
45 Citations (Scopus) -
2015
AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy
Thwaite, R., Pagès, G., Chillón, M. & Bosch, A., 1 Jan 2015, In: Gene Therapy. 22, 2, p. 196-201Research output: Contribution to journal › Article › Research › peer-review
61 Citations (Scopus) -
Secreted and transmembrane αklotho isoforms have different spatio-temporal profiles in the brain during aging and Alzheimer's disease progression
Massó, A., Sánchez, A., Gimenez-Llort, L., Lizcano, J. M., Cañete, M., Garciá, B., Torres-Lista, V., Puig, M., Bosch, A. & Chillon, M., 1 Nov 2015, In: PLoS ONE. 10, 11, p. 1-15 e0143623.Research output: Contribution to journal › Article › Research › peer-review
55 Citations (Scopus) -
2014
Central nervous system delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in mucopolysaccharidosis type VII mice
Ariza, L., Giménez-Llort, L., Cubizolle, A., Pagès, G., García-Lareu, B., Serratrice, N., Cots, D., Thwaite, R., Chillón, M., Kremer, E. J. & Bosch, A., 1 Mar 2014, In: Human Gene Therapy. 25, 3, p. 199-211Research output: Contribution to journal › Article › Research › peer-review
26 Citations (Scopus) -
Experimental diabetes in neonatal mice induces early peripheral sensorimotor neuropathy
Ariza, L., Pagès, G., García-Lareu, B., Cobianchi, S., Otaegui, P. J., Ruberte, J., Chillón, M., Navarro, X. & Bosch, A., 22 Aug 2014, In: Neuroscience. 274, p. 250-259Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Hyperglycemia and hepatic tumors in ICR mice neonatally injected with streptozotocin
Ariza, L., Zaguirre, M., García, M., Blasco, E., Rabanal, R. M., Bosch, A. & Otaegui, P. J., 1 Jan 2014, In: Lab Animal. 43, 7, p. 242-249Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy
Homs, J., Pagès, G., Ariza, L., Casas, C., Chillón, M., Navarro, X. & Bosch, A., 8 Jan 2014, In: Molecular Therapy - Methods and Clinical Development. 1, p. 7 7.Research output: Contribution to journal › Article › Research › peer-review
Open Access29 Citations (Scopus) -
2013
Functional characterization of the human mariner transposon Hsmar2.
Gil, E., Bosch, A., Lampe, D., Lizcano, J. M., Perales, J. C., Danos, O. & Chillon, M., 1 Jan 2013, In: PLoS ONE. 8Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Helper dependent adenovirus vectors: Progress and future prospects
Cots, D., Bosch, A. & Chillón, M., 25 Dec 2013, In: Current Gene Therapy. 13, 5, p. 370-381Research output: Contribution to journal › Article › Research › peer-review
29 Citations (Scopus) -
Short-fiber protein of ad40 confers enteric tropism and protection against acidic gastrointestinal conditions
Rodríguez, E., Romero, C., Río, A., Miralles, M., Raventós, A., Planells, L., Burgueño, J. F., Hamada, H., Perales, J. C., Bosch, A., Gassull, M. A., Fernández, E. & Chillon, M., 1 Aug 2013, In: Human gene therapy methods. 24, p. 195-204Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
2012
Efficient amplification of chimeric adenovirus 5/40s vectors carrying the short fiber protein of ad40 in suspension cell cultures
Miralles, M., Segura, M. M., Puig, M., Bosch, A. & Chillon, M., 31 Jul 2012, In: PLoS ONE. 7, e42073.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Long-term retinal PEDF overexpression prevents neovascularization in a murine adult model of retinopathy
Haurigot, V., Villacampa, P., Ribera, A., Bosch, A., Ramos, D., Ruberte, J. & Bosch, F., 20 Jul 2012, In: PLoS ONE. 7, e41511.Research output: Contribution to journal › Article › Research › peer-review
67 Citations (Scopus) -
2011
Altering the Ad5 packaging domain affects the maturation of the Ad particles
Alba, R., Cots, D., Ostapchuk, P., Bosch, A., Hearing, P. & Chillon, M., 24 May 2011, In: PLoS ONE. 6, e19564.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Comparative study of peripheral neuropathy and nerve regeneration in NOD and ICR diabetic mice
Homs, J., Ariza, L., Pagès, G., Verdú, E., Casals, L., Udina, E., Chillón, M., Bosch, A. & Navarro, X., 1 Sept 2011, In: Journal of the Peripheral Nervous System. 16, p. 213-227Research output: Contribution to journal › Article › Research › peer-review
22 Citations (Scopus) -
Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration
Homs, J., Ariza, L., Pagès, G., Udina, E., Navarro, X., Chillón, M. & Bosch, A., 1 Jan 2011, In: Gene Therapy. 18, p. 622-630Research output: Contribution to journal › Article › Research › peer-review
54 Citations (Scopus) -
2009
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown
Haurigot, V., Villacampa, P., Ribera, A., Llombart, C., Bosch, A., Nacher, V., Ramos, D., Ayuso, E., Segovia, J. C., Bueven, J. A., Ruberte, J. & Bosch, F., 21 Aug 2009, In: Journal of Biological Chemistry. 284, 34, p. 22961-22969Research output: Contribution to journal › Article › Research › peer-review
60 Citations (Scopus) -
2008
Efficient and specific transduction of cochlear supporting cells by adeno-associated virus serotype 5
Ballana, E., Wang, J., Venail, F., Estivill, X., Puel, J. L., Arbonès, M. L. & Bosch, A., 12 Sept 2008, In: Neuroscience Letters. 442, p. 134-139Research output: Contribution to journal › Article › Research › peer-review
27 Citations (Scopus) -
2007
Coxsackie adenovirus receptor and ανβ3/ανβ5 integrins in adenovirus gene transfer of rat cochlea
Venail, F., Wang, J., Ruel, J., Ballana, E., Rebillard, G., Eybalin, M., Arbones, M., Bosch, A. & Puel, J. L., 1 Jan 2007, In: Gene Therapy. 14, p. 30-37Research output: Contribution to journal › Article › Research › peer-review
31 Citations (Scopus) -
Differential amplification of adenovirus vectors by flanking the packaging signal with attB/attP-ΦC31 sequences: Implications for helper-dependent adenovirus production
Alba, R., Hearing, P., Bosch, A. & Chillon, M., 10 Oct 2007, In: Virology. 367, p. 51-58Research output: Contribution to journal › Article › Research › peer-review
35 Citations (Scopus) -
2005
Gutless adenovirus: Last-generation adenovirus for gene therapy
Alba, R., Bosch, A. & Chillon, M., 1 Jan 2005, In: Gene Therapy. 12, p. S18-S27Research output: Contribution to journal › Article › Research › peer-review
224 Citations (Scopus) -
2004
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease
Ruberte, J., Ayuso, E., Navarro, M., Carretero, A., Nacher, V., Haurigot, V., George, M., Llombart, C., Casellas, A., Costa, C., Bosch, A. & Bosch, F., 1 Jan 2004, In: Journal of Clinical Investigation. 113, 8, p. 1149-1157Research output: Contribution to journal › Article › Research › peer-review
165 Citations (Scopus) -
In vivo gene transfer to pancreatic beta cells by systemic delivery of adenoviral vectors
Ayuso, E., Chillón, M., Agudo, J., Haurigot, V., Bosch, A., Carretero, A., Otaegui, P. J. & Bosch, F., 1 Aug 2004, In: Human Gene Therapy. 15, p. 805-812Research output: Contribution to journal › Article › Research › peer-review
32 Citations (Scopus) -
2003
Gene therapy for mucopolysaccharidosis
Bosch, A. & Heard, J. M., 1 Jan 2003, In: International Review of Neurobiology. 55, p. 271-296Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
2002
Malaltia genètica i la medicina del futur
Bosch, A. & Chillón, M., 1 Jan 2002, In: Transversal: revista de cultura contemporània. 17, p. 34-38Research output: Contribution to journal › Article › Dissemination
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2001
Identification of a new HLA-DRB1 allele (DRB1*0318) in three members of a Caucasian spanish family
Ercilla, M. G., Guardia, A., Suárez, B., Arias, M. T., Fabregat, V., Costa, M., Salinas, I., Martorell, J., Vives, J., Lozano, F. & Bosch Merino, M. A., 1 Jan 2001, In: Tissue Antigens. 57, p. 489-491Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Production and Neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins
Desmaris, N., Bosch, A., Salaün, C., Petit, C., Prevost, M. C., Tordo, N., Perrin, P., Schwartz, O., De Rocquigny, H. & Heard, J. M., 1 Aug 2001, In: Molecular therapy (Print). 4, 2, p. 149-156Research output: Contribution to journal › Article › Research
90 Citations (Scopus) -
2000
Improvement of erythropoiesis in beta-thalassemic mice by continuous erythropoietin delivery from muscle
Bohl, D., Bosch, A., Cardona, A., Salvetti, A. & Heard, J., 1 Jan 2000, In: Blood. 95, 9, p. 2793-2798Research output: Contribution to journal › Article › Research › peer-review
56 Citations (Scopus) -
Long-term and significant correction of brain lesions in adult mucopolysaccharidosis type VII mice using recombinant AAV vectors
Bosch, A., Perret, E., Desmaris, N. & Heard, J. M., 1 Jan 2000, In: Molecular therapy (Print). 1, 1, p. 63-70Research output: Contribution to journal › Article › Research
116 Citations (Scopus) -
Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer
Bosch, A., Perret, E., Desmaris, N., Trono, D. & Heard, J. M., 1 Jan 2000, In: Human Gene Therapy. 11, 8, p. 1139-1150Research output: Contribution to journal › Article › Research › peer-review
124 Citations (Scopus) -
Teràpia Gènica. En 'La Biologia a l'alba d'un nou mil.lenni'
Chillón, M. & Bosch, A., 1 Jan 2000, In: Treb. Soc. Catalana Biol.. 50, p. 141-149Research output: Contribution to journal › Article › Dissemination