Research output per year
Research output per year
- 1 - 50 out of 230 results
Search results
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2023
Activity-dependent Nr4a2 induction modulates synaptic expression of AMPA receptors and plasticity via a Ca 2+/ CRTC1/CREB pathway
Catala Solsona, J., Lituma, P. J., Lutzu, S., Siedlecki Wullich, D. J., Fabregas Ordoñez, C., Miñano Molina, A. J., Saura, C. A., Castillo, P. & Rodríguez-Álvarez, J., 26 Apr 2023, In: Journal of Neuroscience. 43, 17, p. 3028-3041 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Is phosphorylated tau a good biomarker of synapse pathology in Alzheimer’s disease ?
Saura, C. A. & Parra Damas, A. J., 27 Apr 2023, In: Brain Communications. 5, 3, p. 1-4 4 p., fcad142.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)1 Downloads (Pure) -
Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics
Saura, C. A., Deprada, A., Capilla-López, M. D. & Parra-Damas, A., 1 Apr 2023, In: Seminars in Cell and Developmental Biology. 139, p. 73-83 11 p.Research output: Contribution to journal › Review article › Research › peer-review
Open Access17 Citations (Scopus) -
The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons
Rivas-Santisteban, R., Raïch, I., Aguinaga, D., Saura, C. A., Franco, R. & Navarro, G., 11 Jan 2023, In: Cells. 12, 2, 10 p., 283.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
2022
Editorial: Bidirectional Communication Between Synapses and Nucleus in Brain Physiology and Disease
Parra-Damas, A., Ch'ng, T. H., Jordan, B. A. & Saura, C. A., 6 May 2022, In: Frontiers in Molecular Neuroscience. 15, 909036.Research output: Contribution to journal › Review article › Research › peer-review
Open Access -
Intrapallidal injection of cannabidiol or a selective GPR55 antagonist decreases motor asymmetry and improves fine motor skills in hemiparkinsonian rats
Patricio, F., Morales Dávila, E., Patricio-Martínez, A., Arana Del Carmen, N., Martínez, I., Aguilera, J., Perez-Aguilar, J. M. & Limón, I. D., 2022, In: Frontiers in Pharmacology. 13Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APPSw,Ind J9 Alzheimer’s Disease Mouse Model
Temprano-Carazo, S., Contreras, A., Saura, C. A., Navarro-López, J. D. & Jiménez-Díaz, L., Nov 2022, In: International journal of molecular sciences. 23, 21, 10 p., 13444.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
The C-terminal domain of the heavy chain of tetanus toxin prevents the oxidative and nitrosative stress induced by acute toxicity of 1-methyl-4-phenylpyridinium, a rat model of Parkinson's disease
Patricio Martinez, F., JUÁREZ TORRES, D., Patricio Martínez, A., Mendieta, L., Pérez Severiano, F., Montes, S., Aguilera, J. & Limón, I. D., Jan 2022, In: Neuroscience Research. 174, p. 36-45 10 p., 174.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
2021
Interaction between a Novel Oligopeptide Fragment of the Human Neurotrophin Receptor TrkB Ectodomain D5 and the C-Terminal Fragment of Tetanus Neurotoxin
Candalija, A., Scior, T., Rackwitz, H.-R., Ruiz-Castelan, J. E., Martinez-Laguna, Y. & Aguilera, J., 1 Jul 2021, In: Molecules. 26, 13, 23 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
microRNAs as Early Biomarkers of Alzheimer's Disease: A Synaptic Perspective
Siedlecki-Wullich, D., Miñano-Molina, A. J. & Rodríguez-Álvarez, J., 9 Jan 2021, In: Cells. 10, 1, p. 1-26 26 p., 113.Research output: Contribution to journal › Review article › Research › peer-review
Open Access43 Citations (Scopus) -
Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction : A Perspective Review
Catala Solsona, J., Miñano-Molina, A. J. & Rodriguez Alvarez, J., 2021, In: Frontiers in Molecular Neuroscience. 14Research output: Contribution to journal › Review article › Research › peer-review
Open Access16 Citations (Scopus) -
Sex differences in fear memory consolidation via Tac2 signaling in mice
Florido, A., Velasco, E. R., Soto-Faguás, C. M., Gomez-Gomez, A., Perez-Caballero, L., Molina, P., Nadal, R., Pozo, O. J., Saura, C. A. & Andero, R., 1 Dec 2021, In: Nature communications. 12, 1, 19 p., 2496.Research output: Contribution to journal › Article › Research › peer-review
Open Access28 Citations (Scopus) -
Three-dimensional vascular microenvironment landscape in human glioblastoma
Cribaro, G. P., Saavedra-López, E., Romarate, L., Mitxitorena, I., Díaz, L. R., Casanova, P. V., Roig-Martínez, M., Gallego, J. M., Perez-Vallés, A. & Barcia, C., 1 Dec 2021, In: Acta Neuropathologica Communications. 9, 1, p. 24 20 p., 24.Research output: Contribution to journal › Article › Research › peer-review
Open Access20 Citations (Scopus) -
Ursolic acid inhibits collective cell migration and promotes JNK-dependent lysosomal associated cell death in glioblastoma multiforme cells
Conway, G. E., Zizyte, D., Mondala, J. R. M., He, Z., Lynam, L., Lecourt, M., Barcia, C., Howe, O. & Curtin, J. F., 26 Jan 2021, In: Pharmaceuticals. 14, 2, p. 1-16 16 p., 91.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
2020
A roadmap to integrate astrocytes into Systems Neuroscience
Kastanenka, K. V., Moreno-Bote, R., De Pittà, M., Perea, G., Eraso-Pichot, A., Masgrau, R., Poskanzer, K. E. & Galea, E., 1 Jan 2020, In: GLIA. 68, 1, p. 5-26 22 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access48 Citations (Scopus) -
Conventional and non-conventional roles of non-muscle myosin II-actin in neuronal development and degeneration
Javier-Torrent, M. & Saura, C. A., 19 Aug 2020, In: Cells. 9, 9Research output: Contribution to journal › Review article › Research › peer-review
Open Access15 Citations (Scopus) -
C-terminal fragment of tetanus toxin (Hc) for treatment of depression
Aguilera, J. (Inventor) & Tizabi, Y. (Inventor), 2020, Patent No. 16/878,809 (EEUU), (2020)Research output: Patent
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La degradació d'una proteïna d'andamiatge està relacionada amb la disminució dels receptors glutamatèrgics AMPA sinàptics
Translated title of the contribution :Degradation of scaffold protein is related to the reduction of synaptic glutamatergic AMPA receptors Research output: Contribution to journal › Article › Dissemination
Open Access -
Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model
Martínez, L. M., Torre, M. D. L., Muñoz, M. J., Zaragoza, P., Aguilera, J., Calvo, A. C. & Osta, R., May 2020, In: Toxins. 12, 5, p. 1-10 10 p., 12.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease.
Herrando Grabulosa, M., Casas Louzao, C., Talbot, K. & Aguilera, J., 21 Oct 2020, In: Toxins. 12, 10, p. 666-675 11 p., 12.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Phagocytic glioblastoma-associated microglia and macrophages populate invading pseudopalisades
Saavedra-López, E., Roig-Martínez, M., Cribaro, G. P., Casanova, P. V., Gallego, J. M., Pérez-Vallés, A. & Barcia, C., 2020, In: Brain Communications. 2, 1, 20 p., fcz043.Research output: Contribution to journal › Article › Research › peer-review
Open Access19 Citations (Scopus) -
Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD
Cheng, W., Siedlecki-Wullich, D., Català-Solsona, J., Fábregas, C., Fadó, R., Casals, N., Solé, M., Unzeta, M., Saura, C. A., Rodríguez-Alvarez, J. & Miñano-Molina, A. J., 1 Mar 2020, In: eNeuro. 7, 2, ENEURO.0218-19.2020.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
Casas, M., Fadó, R., Domínguez, J. L., Roig, A., Kaku, M., Chohnan, S., Solé, M., Unzeta, M., Miñano-Molina, A. J., Rodríguez-Álvarez, J., Dickson, E. J. & Casals, N., 5 Oct 2020, In: Journal of Cell Biology.Research output: Contribution to journal › Article › Research › peer-review
Open Access18 Citations (Scopus) -
Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
Larramona-Arcas, R., González-Arias, C., Perea, G., Gutiérrez, A., Vitorica, J., García-Barrera, T., Gómez-Ariza, J. L., Pascua-Maestro, R., Ganfornina, M. D., Kara, E., Hudry, E., Martinez-Vicente, M., Vila, M., Galea, E. & Masgrau, R., 9 Jun 2020, In: Molecular Neurodegeneration. 15, 1, 35.Research output: Contribution to journal › Article › Research › peer-review
Open Access35 Citations (Scopus) -
The C-terminal fragment of the heavy chain of the tetanus toxin (Hc-TeTx) improves motor activity and neuronal morphology in the limbic system of aged mice.
Vazquez-Roque, R., Aguilera, J., Pacheco-Flores, M., Penagos-Corzo, J., Flores, G., Treviño, S., Guevara, J., Díaz, A. & Venegas, B., 22 Nov 2020, In: Synapse. 12 p., 22193.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Web of Science) -
2019
Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer's disease
Siedlecki-Wullich, D., Català-Solsona, J., Fábregas, C., Hernández, I., Clarimon, J., Lleó, A., Boada, M., Saura, C. A., Rodríguez-Álvarez, J. & Miñano-Molina, A. J., 15 May 2019, In: Alzheimer's Research and Therapy. 11, 1, 46.Research output: Contribution to journal › Article › Research › peer-review
Open Access91 Citations (Scopus) -
Antidepressant effects of C-terminal domain of the heavy chain of tetanus toxin in a rat model of depression
Getachew, B., Mendieta, L., Csoka, A. B., Aguilera, J. & Tizabi, Y., 16 Sept 2019, In: Behavioural Brain Research. 370, p. 111968 5 p., 111968.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition
Solé, M., Esteban-Lopez, M., Taltavull, B., Fábregas, C., Fadó, R., Casals, N., Rodríguez-Álvarez, J., Miñano-Molina, A. J. & Unzeta, M., 1 Sept 2019, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 9, p. 2189-2202 14 p.Research output: Contribution to journal › Article › Research
21 Citations (Scopus) -
Calcium enhances binding of Clostridium perfringens epsilon toxin to sulfatide
Gil, C., Dorca-Arévalo, J. & Blasi, J., 1 Jan 2019, In: Biochimica et Biophysica Acta - Biomembranes. 1861, p. 161-169Research output: Contribution to journal › Article › Research
2 Citations (Scopus) -
Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells
Conway, G. E., He, Z., Hutanu, A. L., Cribaro, G. P., Manaloto, E., Casey, A., Traynor, D., Milosavljevic, V., Howe, O., Barcia, C., Murray, J. T., Cullen, P. J. & Curtin, J. F., 1 Dec 2019, In: Scientific Reports. 9, 1, 12891.Research output: Contribution to journal › Article › Research › peer-review
Open Access37 Citations (Scopus) -
Control of brain state transitions with light
Barbero, A., Riefolo, F., Matera, C., Claro, E., Sánchez-Vives, M. V. & Gorostiza, P., 1 Jan 2019, In: BioRxiv. p. -Research output: Contribution to journal › Article › Research
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Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis
Lopez-Font, I., Sogorb-Esteve, A., Javier-Torrent, M., Brinkmalm, G., Herrando-Grabulosa, M., García-Lareu, B., Turon-Sans, J., Rojas-García, R., Lleó, A., Saura, C. A., Zetterberg, H., Blennow, K., Bosch, A., Navarro, X. & Sáez-Valero, J., 1 Apr 2019, In: Neurobiology of Disease. 124, p. 428-438Research output: Contribution to journal › Article › Research
12 Citations (Scopus) -
Defined neuronal populations drive fatal phenotype in a mouse model of leigh syndrome
Bolea, I., Gella, A., Sanz, E., Prada-Dacasa, P., Menardy, F., Bard, A. M., Machuca-Msárquez, P., Eraso-Pichot, A., Mòdol-Caballero, G., Navarro, X., Kalume, F. & Quintana, A., 1 Aug 2019, In: eLife. 8, e47163.Research output: Contribution to journal › Article › Research
32 Citations (Scopus) -
Differential Expression of Striatal FosB mRNA and FosB mRNA After Different Levodopa Treatment Regimens in a Rat Model of Parkinson's Disease
Palafox-Sanchez, V., Sosti, V., Ramirez-García, G., Kulisevsky, J., Aguilera, J. & Limón, I. D., 15 Apr 2019, In: Neurotoxicity Research. 35, 3, p. 563-574 12 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties
Agnetta, L., Bermudez, M., Riefolo, F., Matera, C., Claro, E., Messerer, R., Littmann, T., Wolber, G., Holzgrabe, U. & Decker, M., 28 Mar 2019, In: Journal of Medicinal Chemistry. 62, p. 3009-3020Research output: Contribution to journal › Article › Research
32 Citations (Scopus) -
Optical Control of Cardiac Function with a Photoswitchable Muscarinic Agonist
Riefolo, F., Matera, C., Garrido-Charles, A., Gomila, A. M. J., Sortino, R., Agnetta, L., Claro, E., Masgrau, R., Holzgrabe, U., Batlle, M., Decker, M., Guasch, E. & Gorostiza, P., 8 May 2019, In: Journal of the American Chemical Society. 141, 18, p. 7628-7636 9 p.Research output: Contribution to journal › Article › Research
46 Citations (Scopus) -
Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists
Franco, R., Reyes-Resina, I., Aguinaga, D., Lillo, A., Jiménez, J., Raïch, I., Borroto-Escuela, D. O., Ferreiro-Vera, C., Canela, E. I., Sánchez de Medina, V., del Ser-Badia, A., Fuxe, K., Saura, C. A. & Navarro, G., 1 Dec 2019, In: GLIA. 67, 12, p. 2410-2423 14 p.Research output: Contribution to journal › Article › Research
40 Citations (Scopus) -
Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA
Javier-Torrent, M., Marco, S., Rocandio, D., Pons-Vizcarra, M., Janes, P. W., Lackmann, M., Egea, J. & Saura, C. A., 2 Oct 2019, In: eLife. 8Research output: Contribution to journal › Article › Research
13 Citations (Scopus) -
Synapse-to-Nucleus Signaling in Neurodegenerative and Neuropsychiatric Disorders
Parra-Damas, A. & Saura, C. A., 15 Jul 2019, In: Biological Psychiatry. 86, 2, p. 87-96Research output: Contribution to journal › Review article › Research › peer-review
28 Citations (Scopus) -
2018
GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes
Eraso-Pichot, A., Brasó-Vives, M., Golbano, A., Menacho, C., Claro, E., Galea, E. & Masgrau, R., 1 Aug 2018, In: Glia. 66, 8, p. 1724-1735Research output: Contribution to journal › Article › Research › peer-review
66 Citations (Scopus)2 Downloads (Pure) -
Molecular and functional interaction between GPR18 and cannabinoid CB<inf>2</inf> G-protein-coupled receptors. Relevance in neurodegenerative diseases
Reyes-Resina, I., Navarro, G., Aguinaga, D., Canela, E. I., Schoeder, C. T., Załuski, M., Kieć-Kononowicz, K., Saura, C. A., Müller, C. E. & Franco, R., 1 Nov 2018, In: Biochemical Pharmacology. 157, p. 169-179Research output: Contribution to journal › Article › Research
58 Citations (Scopus) -
N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APP<inf>Sw,Ind</inf> Mice
Franco, R., Aguinaga, D., Reyes, I., Canela, E. I., Lillo, J., Tarutani, A., Hasegawa, M., del Ser-Badia, A., del Rio, J. A., Kreutz, M. R., Saura, C. A. & Navarro, G., 28 Aug 2018, In: Frontiers in Molecular Neuroscience. 11, 273.Research output: Contribution to journal › Article › Research › peer-review
Open Access22 Citations (Scopus) -
Peripheral Administration of Tetanus Toxin Hc Fragment Prevents MPP+ Toxicity In Vivo
Moreno-Galarza, N., Mendieta, L., Palafox-Sánchez, V., Herrando-Grabulosa, M., Gil, C., Limón, D. I. & Aguilera, J., 1 Jul 2018, In: Neurotoxicity Research. 34, 1, p. 47-61 15 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Proteolytic processing of neurexins by presenilins sustains synaptic vesicle release
Servián-Morilla, E., Robles-Lanuza, E., Sánchez-Hidalgo, A. C., Camacho-Garcia, R. J., Paez-Gomez, J. A., Mavillard, F., Saura, C. A., Martinez-Mir, A. & Scholl, F. G., 24 Jan 2018, In: Journal of Neuroscience. 38, 4, p. 901-917Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB<inf>1</inf> and CB<inf>2</inf> receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia
Navarro, G., Borroto-Escuela, D., Angelats, E., Etayo, Í., Reyes-Resina, I., Pulido-Salgado, M., Rodríguez-Pérez, A. I., Canela, E. I., Saura, J., Lanciego, J. L., Labandeira-García, J. L., Saura, C. A., Fuxe, K. & Franco, R., 1 Jan 2018, In: Brain, Behavior, and Immunity. 67, p. 139-151Research output: Contribution to journal › Article › Research › peer-review
103 Citations (Scopus) -
Reducing the levels of akt activation by PDK1 knock-in mutation protects neuronal cultures against synthetic amyloid-beta peptides
Yang, S., Pascual-Guiral, S., Ponce, R., Giménez-Llort, L., Baltrons, M. A., Arancio, O., Palacio, J. R., Clos, V. M., Yuste, V. J. & Bayascas, J. R., 8 Jan 2018, In: Frontiers in Aging Neuroscience. 9, 435, 435.Research output: Contribution to journal › Article › Research › peer-review
Open Access31 Citations (Scopus)2 Downloads (Pure) -
Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
Van Der Jeugd, A., Parra-Damas, A., Baeta-Corral, R., Soto-Faguás, C. M., Ahmed, T., Laferla, F. M., Giménez-Llort, L., D'Hooge, R. & Saura, C. A., 1 Dec 2018, In: Scientific Reports. 8, 6431.Research output: Contribution to journal › Article › Research
Open Access37 Citations (Scopus) -
Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade
Gulisano, W., Maugeri, D., Baltrons, M. A., Fà, M., Amato, A., Palmeri, A., D'Adamio, L., Grassi, C., Devanand, D. P., Honig, L. S., Puzzo, D. & Arancio, O., 1 Jan 2018, In: Journal of Alzheimer's Disease. 64, s1, p. S611-S631Research output: Contribution to journal › Review article › Research › peer-review
Open Access143 Citations (Scopus) -
Simvastatin blocks soluble SSAO/VAP-1 release in experimental models of cerebral ischemia: Possible benefits for stroke-induced inflammation control
Sun, P., Hernandez-Guillamón, M., Campos-Martorell, M., Simats, A., Montaner, J., Unzeta, M. & Solé, M., 1 Feb 2018, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 2, p. 542-553Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
Structural insights into positive and negative allosteric regulation of a G protein-coupled receptor through protein-lipid interactions
Bruzzese, A., Gil, C., Dalton, J. A. R. & Giraldo, J., 1 Dec 2018, In: Scientific Reports. 8, 4456, p. - 4456.Research output: Contribution to journal › Article › Research
35 Citations (Scopus)