Projects per year
Organisation profile
Organisation profile
El nostre grup de recerca estudia els mecanismes mol·leculars i cel·lulars subjacents a la
pèrdua de memòria i els trastorns neuropsiquiàtrics en el cervell humà durant l'envelliment
biològic i patològic.Volem conèixer els mecanismes moleculars implicats en la diferent
vulnerabilitat cel·lular en el cervell en etapes inicials de la malaltia d'Alzheimer.Per aquest
fi, utilitzem tècniques experimentals d'última generació-genòmica, transcriptòmica i
proteòmica- en nous models de la malaltia d'Alzheimer generats en el nostre laboratori que
permeten estudiar el transcriptoma en poblacions cel.lulars específiques.La combinació de
tècniques de fisiologia i patologia amb aproximacions de Biologia de Sistemes ens permet
correlacionar els canvis transcriptòmics i patològics en tipus cel·lulars i regions cerebrals
específiques relacionades amb la memòria i les emocions. Aquesta informació és enormement
rellevant per desenvolupar noves estratègies diagnòstiques i terapèutiques en l'Alzheimer.
Directed by:
Carlos Alberto Saura Antolín
Research lines
- Research lines:
- Pathological mechanisms associated with synaptic dysfunction in dementias, including Alzheimer's disease
- Study of the transcriptome and proteome of specific cellular populations in dementia
- Development of new therapeutic strategies to modulate neuronal circuits in Alzheimer's disease
- New biomarkers for the early diagnosis of Alzheimer's disease
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Dive into the research topics where Recerca Biomèdica en la Malaltia d'Alzheimer is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Jose Rodriguez Alvarez
- Department of Biochemistry and Molecular Biology
- Recerca Biomèdica en la Malaltia d'Alzheimer
- Institute of Neuroscience (INc)
Person: Professor, Affiliation to research
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Sex-specific vulnerability mediated by parvalbumin neurons in Alzheimer’s disease
Parra Damas, A. J. (Principal Investigator)
1/11/24 → 31/10/27
Project: International research project
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TRANSCRIPTIONAL ANALYSIS AND FUNCTIONAL MODULATION OF MEMORY NEURAL CIRCUITS IN ALZHEIMERS DISEASE
Saura Antolin, C. A. (Principal Investigator), Capilla Lopez, M. D. (Collaborator), Delprat Obeaga, M. A. (Collaborator), Deprada Fernandez, A. (Collaborator), Fernandez Olalla, X. (Collaborator), Parra Damas, A. J. (Collaborator), Aguilera Avila, J. (Investigator) & Sotillo Sotillo, P. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
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Modulación terapéutica del epitranscriptoma neuronal en demencia
Fernandez Olalla, X. (Collaborator), Parra Damas, A. J. (Investigator), Aguilera Avila, J. (Investigator), Saura Antolin, C. A. (Principal Investigator), Delprat Obeaga, M. A. (Collaborator) & Martin Pinardi, L. (Collaborator)
1/12/22 → 31/08/25
Project: Research Projects and Other Grants
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Activity-dependent Nr4a2 induction modulates synaptic expression of AMPA receptors and plasticity via a Ca 2+/ CRTC1/CREB pathway
Catala Solsona, J., Lituma, P. J., Lutzu, S., Siedlecki Wullich, D. J., Fabregas Ordoñez, C., Miñano Molina, A. J., Saura, C. A., Castillo, P. & Rodríguez-Álvarez, J., 26 Apr 2023, In: Journal of Neuroscience. 43, 17, p. 3028-3041 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Is phosphorylated tau a good biomarker of synapse pathology in Alzheimer’s disease ?
Saura, C. A. & Parra Damas, A. J., 27 Apr 2023, In: Brain Communications. 5, 3, p. 1-4 4 p., fcad142.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)1 Downloads (Pure) -
Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics
Saura, C. A., Deprada, A., Capilla-López, M. D. & Parra-Damas, A., 1 Apr 2023, In: Seminars in Cell and Developmental Biology. 139, p. 73-83 11 p.Research output: Contribution to journal › Review article › Research › peer-review
Open Access16 Citations (Scopus)
Student theses
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Role of Nr4a2 transcription factor in hippocampal synaptic plasticity. Possible therapeutic target for Alzheimer's disease.
Catala Solsona, J. (Author), Rodríguez-Álvarez, J. (Director) & Rodriguez Alvarez, J. (Tutor), 12 Jun 2020Student thesis: Doctoral thesis
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Efectos de la restricción calórica en el envejecimiento cerebral y cognitivo: estudio de los niveles de monoaminas.
Cristina Vega Carbajal (Author), Aguilera Avila, J. (Director) & Martí Nicolovius, M. (Director), 10 Sept 2015Student thesis: Final degree project (TFG)
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Modulación del transporte de serotonina en cultivos de neuronas corticales primarias por neurotoxinas clostridiales y por sustancias que afectan la actividad tirosina quinasa.
Pelliccioni, P. M. (Author), Aguilera Avila, J. (Director), 1997Student thesis: Dissertation (TFM)