Organisation profile

The Mitochondrial Neuropathology SGR group is devoted to elucidating the mechanisms whereby
mitochondrial dysfunction leads to neurodegeneration to develop novel treatments for
pathologies with mitochondrial involvement, including rare diseases caused by mutations of
mitochondrial genes, the so-called primary mitochondrial disease (MD), as well as
neurodegenerative diseases such as Alzheimer's disease (AD), which very particularly affect
mitochondria, necessary for providing most of the energy to cells. Thus, the overarching goal
of this SGR is the implementation of Mitochondrial Medicine, defined as a basic and clinical
discipline dedicated to understanding, diagnosing and treating MD and mitochondrion-involved
disease such as AD. To that end, we focus on 3 axes; 1) characterizing cellular and neuralcircuit heterogeneity and disease-specificity, 2) developing new tools for manipulation and in
vivo exploration of mitochondrial activity, and 3) clinical translation.