Projects per year
Organisation profile
Organisation profile
The Mitochondrial Neuropathology SGR group is devoted to elucidating the mechanisms whereby
mitochondrial dysfunction leads to neurodegeneration to develop novel treatments for
pathologies with mitochondrial involvement, including rare diseases caused by mutations of
mitochondrial genes, the so-called primary mitochondrial disease (MD), as well as
neurodegenerative diseases such as Alzheimer's disease (AD), which very particularly affect
mitochondria, necessary for providing most of the energy to cells. Thus, the overarching goal
of this SGR is the implementation of Mitochondrial Medicine, defined as a basic and clinical
discipline dedicated to understanding, diagnosing and treating MD and mitochondrion-involved
disease such as AD. To that end, we focus on 3 axes; 1) characterizing cellular and neuralcircuit heterogeneity and disease-specificity, 2) developing new tools for manipulation and in
vivo exploration of mitochondrial activity, and 3) clinical translation.
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Collaborations and top research areas from the last five years
Profiles
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Laura Cutando Ruiz
- Department of Cellular Biology, Physiology and Immunology
- Institute of Neuroscience (INc)
- Mitochondrial Neuropathology
Person: Assignment to research, Post-doctoral researcher staff projects
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(Dis)función mitocondrial en enfermedades neurodegenerativas
Quintana Romero, A., Puighermanal Puigvert, E., Sanz Iglesias, E., Brito, V., Cavaliere, F., Giralt Torroella, A., José, R., Laguna, A., Martinez-Vicente, M., Ruiz, A., d'Anglemont de Tassigny, X., COLELL RIERA, A., Gines Padros, S., Matute Almau, C., Miñano Molina, A. J., Trullas Oliva, R., Vila Bover, Miquel & gonzalez rodriguez, P.
1/06/23 → 31/05/25
Project: Research Projects and Other Grants
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AMR-Chip: Desenvolupament d'un kit de diagnòstic ràpid per a les resistències bacterianes
Quintana Romero, A., Espasa Soley, M., Gella Concustell, A., Quijada Pich, O., Sanz Iglesias, E., Urpi Badell, A., Frankenfeld, K. & Sanchez Benito, L.
19/10/22 → 18/04/24
Project: Research Projects and Other Grants
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STUDY OF CANNABIDIOL AND ITS MECHANISM OF ACTION FOR THE TREATMENT OF LEIGH SYNDROME
Puighermanal Puigvert, E., Appiah , I., Quintana Romero, A., Dominguez Martinez, A., Girona del Pozo, M., Van Der Walt ., G. & De Donato, M. H.
1/09/22 → 31/08/25
Project: Research Projects and Other Grants
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Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
Aguilar, K., Comes, G., Canal, C., Quintana, A., Sanz, E. & Hidalgo, J., Nov 2022, In: Glia. 70, 11, p. 2032-2044 13 p., doi: 10.1002/glia.24234.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Web of Science) -
Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention
Van De Wal, M. A. E., Adjobo-Hermans, M. J. W., Keijer, J., Schirris, T. J. J., Homberg, J. R., Wieckowski, M. R., Grefte, S., Van Schothorst, E. M., Van Karnebeek, C., Quintana, A. & Koopman, W. J. H., 1 Jan 2022, In: Brain. 145, 1, p. 45-63 19 p.Research output: Contribution to journal › Review article › Research › peer-review
Open Access15 Citations (Web of Science) -
[Molecular heterogeneity of striatal D2 neurons].
Puighermanal Puigvert, E., 19 Mar 2021, In: Medecine sciences : M/S. 37, p. 219-221 3 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Student theses
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Estudio del perfil traduccional citosólico y mitocondrial de poblaciones neuronales susceptibles a la deficiencia del complejo I mitocondrial
Author: Prada Dacasa, P., 11 Dec 2022Supervisor: Quintana Romero, A. (Director), Sanz Iglesias, E. (Director) & Hidalgo Pareja, J. (Tutor)
Student thesis: Doctoral thesis
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Investigation into the protection of mitochondrial disease pathology by metallothionein overexpression
Author: Miller, H., Jul 2020Supervisor: Quintana Romero, A. (Director) & van der Westhuizen, F. H. (External person) (Director)
Student thesis: Doctoral thesis