Projects per year
Organisation profile
Organisation profile
The group aims to significantly contribute to the understanding of the molecular mechanisms involved in neurologic and psychiatric diseases, in particular, chronic pain, Alzheimer's and Lesch-Nyhan diseases and schizophrenia. An integrative multidisciplinary approach is applied including in silico, in vitro, animal models, and human research. In this context, G proteincoupled receptors, in particular, the mu-, delta-, and kappa-opioid receptors, cannabinoid CB1 and CB2 and dopamine D2 receptor, as well as ion channels, such as TRPV, are used as therapeutic targets. In addition, colloidal systems that incorporate complexed metals which allow the release of CO for pain modulation are included. The investigations also incorporate brain delivery of Alzheimer’s antiamyloidogenic agents in the form of encapsulated dendrimers using nano-vehicles that can be extended to other pathologies. Functional studies are complemented by synchrotron-based imaging techniques on human brain samples.
Directed by:
Jesús Giraldo Arjonilla
Research lines
- Research lines:
- Biochemical and neurodevelopmental alterations in Lesch-Nyhan disease.
- Structural biology of Alzheimer's disease.
- New therapies for chronic pain.
- CO-releasing lipid systems for biomedical purposes.
- Exploring pharmacological therapies through computational approaches.
Fingerprint
Collaborations and top research areas from the last five years
Profiles
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Ramon Barnadas Rodríguez
- Department of Biochemistry and Molecular Biology
- Institute of Neuroscience (INc)
- Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics
Person: Associate lecturer (non-goverment employee), Affiliation to research
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David Garcia Quintana
- Department of Biochemistry and Molecular Biology
- Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics
Person: Associate lecturer (non-goverment employee), Affiliation to research
Projects
- 1 Active
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EVALUACION DE LA COMPLEJIDAD FUNCIONAL DE LOS GPCRS MEDIANTE METODOS COMPUTACIONALES: EL DOLOR CRONICO DESDE UNA PERSPECTIVA DE FARMACOLOGIA MOLECULAR
Giraldo Arjonilla, J. (Principal Investigator), BEDINI, A. (Collaborator), DIAZ SANZO, O. (Collaborator), Marín, A. R. (Collaborator), Van Calenbergh, S. (Collaborator), Romero Sanchez, D. (Investigator), Ortíz García, A. J. (Collaborator) & Severo Gomes, A. A. (Collaborator)
1/09/21 → 31/08/25
Project: Research Projects and Other Grants
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HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease
Esandi, J., Renault, P., Capilla-López, M. D., Blanch, R., Edo, Á., Ramirez-Gómez, D., Bosch, A., Almolda, B., Saura, C. A., Giraldo, J. & Chillón, M., Feb 2025, In: Biomedicine and Pharmacotherapy. 183, 13 p., 117815.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling
Wang, X., Zhang, C., Ye, L., Giraldo, J., Madsen, J. J. & Wang, L., 10 Jan 2024, In: Molecular Pharmacology. 105, 1, p. 54-62 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
CHIR99021 causes inactivation of Tyrosine Hydroxylase and depletion of dopamine in rat brain striatum
Hamdon, S., Fernandez-Gonzalez, P., Omar, M. Y., González-Sepúlveda, M., Ortiz, J. & Gil, C., 1 Jan 2024, In: Neuropharmacology. 242, 11 p., 109759.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)2 Downloads (Pure)
Datasets
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Additional file 1 of Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors
König, C. (Creator), Cárdenas, M. I. (Creator), Giraldo, J. (Creator), Alquézar, R. (Creator) & Vellido, A. (Creator), figshare, 29 Sept 2015
DOI: 10.6084/m9.figshare.c.3623084_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Label_noise_in_subtype_discrimination_of_class_C_G_protein-coupled_receptors_A_systematic_approach_to_the_analysis_of_classification_errors/4400093/1
Dataset
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Data of the article Properties and cellular uptake of photo-triggered mixed metallosurfactant vesicles intended for controlled CO delivery in gas therapy published in Colloids and Surfaces B: Biointerfaces 228 (2023) 11342
Trallero Morales, J. (Creator), Mercedes Camacho Pérez de Madrid (Creator), Marín-García, M. (Creator), Alvarez Marimon, M. E. (Creator), Benseny Cases, N. (Creator) & Barnadas Rodríguez, R. (Creator), CORA.Repositori de Dades de Recerca, 7 Jul 2023
DOI: https://doi.org/10.34810/data774
Dataset
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GNAO1 encephalopathy: further delineation of a severe neurodevelopmental syndrome affecting females
Marc�-Grau, A. (Contributor), Dalton, J. (Creator), L�pez-Pis�n, J. (Contributor), Monge-Galindo, L. (Creator), Cuenca-Le�n, E. (Contributor), Giraldo Arjonilla, J. (Creator) & Macaya, A. (Creator), figshare, 12 Apr 2016
DOI: 10.6084/m9.figshare.c.3646136.v1, https://figshare.com/collections/GNAO1_encephalopathy_further_delineation_of_a_severe_neurodevelopmental_syndrome_affecting_females/3646136/1
Dataset
Student theses
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Alteraciones bioquímicas y del neurodesarrollo en la enfermedad de Lesch-Nyhan. Análisis enzimático de ATIC
Etxaniz Castrillo, U. (Author), Lopez Blanco, J. M. (Director), 2022Student thesis: Final degree project (TFG)
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INVESTIGATION OF THE INFLUENCE OF THE MEMBRANE LIPID ENVIRONMENT ON G PROTEIN-COUPLED RECEPTOR ACTIVATION BY MOLECULAR DYNAMICS SIMULATIONS
Bruzzese Novoa, A. A. (Author), James Andrew Rupert, D. (Director), Giraldo Arjonilla, J. (Tutor) & Giraldo Arjonilla, J. (Director), 24 Feb 2021Student thesis: Doctoral thesis
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ATIC Enzyme Activity in Lesch-Nyhan Disease
Vela Martínez, M. (Author), Lopez Blanco, J. M. (Director), 2022Student thesis: Final degree project (TFG)