Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics

  • Postal addressShow on map

    Edifici M, Campus UAB

    08193 Bellaterra (Cerdanyola del Vallès)

    Spain

Organisation profile

Organisation profile

The group aims to significantly contribute to the understanding of the molecular mechanisms involved in neurologic and psychiatric diseases, in particular, chronic pain, Alzheimer's and Lesch-Nyhan diseases and schizophrenia. An integrative multidisciplinary approach is applied including in silico, in vitro, animal models, and human research. In this context, G proteincoupled receptors, in particular, the mu-, delta-, and kappa-opioid receptors, cannabinoid CB1 and CB2 and dopamine D2 receptor, as well as ion channels, such as TRPV, are used as therapeutic targets. In addition, colloidal systems that incorporate complexed metals which allow the release of CO for pain modulation are included. The investigations also  incorporate brain delivery of Alzheimer’s antiamyloidogenic agents in the form of encapsulated dendrimers using nano-vehicles that can be extended to other pathologies. Functional studies are complemented by synchrotron-based imaging techniques on human brain samples.

Directed by:

Jesús Giraldo Arjonilla

Research lines

  • Research lines:
  • Biochemical and neurodevelopmental alterations in Lesch-Nyhan disease.
  • Structural biology of Alzheimer's disease.
  • New therapies for chronic pain.
  • CO-releasing lipid systems for biomedical purposes.
  • Exploring pharmacological therapies through computational approaches.

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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