Projects per year
Organisation profile
Organisation profile
The group aims to significantly contribute to the understanding of the molecular mechanisms
involved in neurologic and psychiatric diseases, in particular, chronic pain, Alzheimer's and
Lesch-Nyhan diseases and schizophrenia. An integrative multidisciplinary approach is applied
including in silico, in vitro, animal models, and human research. In this context, G proteincoupled receptors, in particular, the mu-, delta-, and kappa-opioid receptors, cannabinoid CB1
and CB2 and dopamine D2 receptor, as well as ion channels, such as TRPV, are used as
therapeutic targets. In addition, colloidal systems that incorporate complexed metals which
allow the release of CO for pain modulation are included. The investigations also incorporate
brain delivery of Alzheimer’s antiamyloidogenic agents in the form of encapsulated dendrimers
using nano-vehicles that can be extended to other pathologies. Functional studies are
complemented by synchrotron-based imaging techniques on human brain samples.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Profiles
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Ramon Barnadas Rodríguez
- Department of Biochemistry and Molecular Biology
- Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics
- Centre for Biophysics Studies (CEB)
Person: Associate lecturer (non-goverment employee), Assignment to research
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David Garcia Quintana
- Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics
- Department of Biochemistry and Molecular Biology
- Centre for Biophysics Studies (CEB)
Person: Associate lecturer (non-goverment employee), Assignment to research
Projects
- 3 Active
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UNI PROB: Testing for the universal mind using probabilistic inference
Lafuente Sancho, F. J., Giraldo Arjonilla, J., Tylor, A., Taylor , A. H., Kean , D. E., Johnston, M. J., Vasoya, H. N. & Shair Ali, E. G.
1/05/23 → 30/04/28
Project: International research project
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LIPID-BASED NANOSYSTEMS FOR BIOMEDICAL APPLICATIONS.
Cladera Cerda, J. B., Barnadas Rodríguez, R., Camacho, M., Barnadas Rodríguez, R., Serrano Pérez, E. & Castillo-Michel, H.
1/09/22 → 31/08/25
Project: Research Projects and Other Grants
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EVALUACION DE LA COMPLEJIDAD FUNCIONAL DE LOS GPCRS MEDIANTE METODOS COMPUTACIONALES: EL DOLOR CRONICO DESDE UNA PERSPECTIVA DE FARMACOLOGIA MOLECULAR
Giraldo Arjonilla, J., Romero Sánchez, D., BEDINI, A., DIAZ SANZO, O., Marín, A. R., Van Calenbergh, S., Severo Gomes, A. A., Ortiz García, A. J. & Ortíz García, A. J.
1/09/21 → 31/08/24
Project: Research Projects and Other Grants
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Allosteric binding cooperativity in a kinetic context
Díaz, Ó., Martín, V., Renault, P., Romero, D., Giraldo, J. & Guillamon, A., Feb 2023, In: Drug Discovery Today. 28, 2, 8 p., 103441.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases
Loch, R. A., Wang, H., Perálvarez-Marín, A., Berger, P., Nielsen, H., Chroni, A. & Luo, J., Jan 2023, In: Computational and Structural Biotechnology Journal. 21, p. 1189-1204 16 p.Research output: Contribution to journal › Review article › Research › peer-review
Open Access1 Citation (Scopus) -
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Haney, M., Vallée, M., Fabre, S., Collins Reed, S., Zanese, M., Campistron, G., Arout, C. A., Foltin, R. W., Cooper, Z. D., Kearney-Ramos, T., Metna, M., Justinova, Z., Schindler, C., Hebert-Chatelain, E., Bellocchio, L., Cathala, A., Bari, A., Serrat, R., Finlay, D. B., Caraci, F., & 18 others, Jun 2023, In: Nature Medicine. 29, 6, p. 1487-1499 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
Datasets
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Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors
König, C. (Creator), Cárdenas, M. I. (Creator), Giraldo Arjonilla, J. (Creator), Alquézar, R. (Creator) & Vellido, A. (Creator), figshare, 29 Sept 2015
DOI: 10.6084/m9.figshare.c.3623084.v1, https://figshare.com/collections/Label_noise_in_subtype_discrimination_of_class_C_G_protein-coupled_receptors_A_systematic_approach_to_the_analysis_of_classification_errors/3623084/1
Dataset
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Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors
König, C. (Creator), Cárdenas, M. I. (Creator), Giraldo Arjonilla, J. (Creator), Alquézar, R. (Creator) & Vellido, A. (Creator), figshare, 29 Sept 2015
DOI: 10.6084/m9.figshare.c.3623084, https://figshare.com/collections/Label_noise_in_subtype_discrimination_of_class_C_G_protein-coupled_receptors_A_systematic_approach_to_the_analysis_of_classification_errors/3623084
Dataset
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Additional file 1 of Label noise in subtype discrimination of class C G protein-coupled receptors: A systematic approach to the analysis of classification errors
König, C. (Creator), Cárdenas, M. I. (Creator), Giraldo Arjonilla, J. (Creator), Alquézar, R. (Creator) & Vellido, A. (Creator), figshare, 29 Sept 2015
DOI: 10.6084/m9.figshare.c.3623084_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Label_noise_in_subtype_discrimination_of_class_C_G_protein-coupled_receptors_A_systematic_approach_to_the_analysis_of_classification_errors/4400093/1
Dataset
Student theses
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Calcium signalling by metabotropic glutamate receptor 5 as a tool to study crosstalk with dopamine D2 receptor.
Author: Mª Victoria García Castiglioni , 14 Jul 2016Supervisor: Gil Giro, C. (Director) & Ortiz de Pablo, J. (Director)
Student thesis: Dissertation (TFM)
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INVESTIGATION OF THE INFLUENCE OF THE MEMBRANE LIPID ENVIRONMENT ON G PROTEIN-COUPLED RECEPTOR ACTIVATION BY MOLECULAR DYNAMICS SIMULATIONS
Author: Bruzzese Novoa, A. A., 24 Feb 2021Supervisor: James Andrew Rupert, D. (External person) (Director), Giraldo Arjonilla, J. (Tutor) & Giraldo Arjonilla, J. (Director)
Student thesis: Doctoral thesis