Projects per year
Organisation profile
Organisation profile
Our research focuses on developing gene therapy approaches for highly prevalent diseases, such
as diabetes mellitus and obesity, and rare metabolic/neurodegenerative diseases. Obesity and
type 2 diabetes, strongly associated with deficits in cognitive function, are a major health
problem because of their alarming growing prevalence worldwide. Novel adeno-associated viral
(AAV) vector-mediated gene therapy strategies are used to target these pathophysiological
processes. We are also developing gene therapies for Mucopolysaccharidosis, a group of
devastating lysosomal storage diseases that currently lack effective treatments. We aim at
developing gene therapies that are minimally invasive, safe and could guarantee maximal
efficacy in the most affected organs. The know-how derived from these studies is also used to
assess the effectiveness of AAV-based gene therapeutics products to counteract other
neurodegenerative diseases and rare diseases affecting the skeletal system in mouse models
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Profiles
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Ivet Elias Puigdomenech
- Department of Biochemistry and Molecular Biology
- Centre for Animal Biotechnology and gene Therapy (CBATEG)
- Laboratori d'Enginyeria Genètica Animal i Teràpia Gènica
Person: Superior technician research support , Accredited TSR, Assignment to research, Adjunct lecturer (non-goverment employee)
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Miguel García Martínez
- Department of Biochemistry and Molecular Biology
- Centre for Animal Biotechnology and gene Therapy (CBATEG)
- Laboratori d'Enginyeria Genètica Animal i Teràpia Gènica
Person: Superior technician research support , Accredited TSR, Assignment to research, Adjunct lecturer (non-goverment employee)
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DESARROLLO PRECLINICO DE ALTO RENDIMIENTO DE NUEVAS TERAPIAS GENICAS PARA ENFERMEDADES RARAS QUE AFECTAN AL SISTEMA NERVIOSO CENTRAL Y AL HUESO (QRARE)
Bosch Tubert, M. F., Bertolin Galvez, J., Casaña Lorente, E., Elias Bosch, G., Ferré Masferrer, M. D. T., Grass Costa, I., Jaen Sitges, M. L., Jambrina Pallares, C., Molas Laplana, M., Morro Larrubia, M., Muñoz Forero, S. A., Pujol, A., Roca Lecha, C., Sacristan Fraile, V., Sanchez Clares, V., Casellas Comallonga, A., Elias Puigdomenech, I., Franckhauser Vogel, S. L., García Martínez, M., Jimenez Cenzano, V., León Madrenas, X., Marcó Costa, S., Ribera Sanchez, A. & Perea Atiénzar, M.
1/01/21 → 31/12/23
Project: Research Projects and Other Grants
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CIBERDEM: CIBERDEM_ Disfunción, destrucción, regeneración del islote Autoinmunidad
Bosch Tubert, M. F., Barrero Victorio, J., Carretero Romay, A. M., Casaña Lorente, E., Casellas Comallonga, A., Elias Puigdomenech, I., Ferré Masferrer, M. D. T., Franckhauser Vogel, S. L., García Martínez, M., Jambrina Pallares, C., Jimenez Cenzano, V., León Madrenas, X., Melgarejo Bermudez, V., Molas Laplana, M., Morro Larrubia, M., Moya Martínez, M., Muñoz Forero, S. A., Nacher Garcia, V., Otaegui Goya, P. J., Pujol, A., Ribera Sanchez, A., Roca Lecha, C., Ruberte Paris, J., Vila Prats, L., Zaguirre Sánchez, M., Marcó Costa, S., Jaen Sitges, M. L., Sacristan Fraile, V. & Navarro Beltran, M.
1/01/09 → 31/12/30
Project: Research Projects and Other Grants
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Transferencia génica al snc mediada por vectores aav para el estudio y tratamiento de la neuroinflamacion asociada a diabetes y obesidad
Bosch Tubert, M. F., Elias Puigdomenech, I., Ferré Masferrer, M. D. T., Franckhauser Vogel, S. L., García Martínez, M., Haurigot Mendoça, V., Jimenez Cenzano, V., León Madrenas, X., Marcó Costa, S., Molas Laplana, M., Muñoz Forero, S. A., Ribera Sanchez, A., Roca Lecha, C., Mallol Dominguez, C., Morro Larrubia, M., Motas Mallol, S., Casellas Comallonga, A., Vilà Prats, L. & Grass Costa, I.
Ministry of Economy and Competitiveness (MINECO)
1/01/18 → 31/12/20
Project: Research Projects and Other Grants
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Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
3 Feb 2023, (E-pub ahead of print) In: BMC Biology. 21, 15 p., 22.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity
Casana, E., Jimenez, V., Jambrina, C., Sacristan, V., Muñoz, S., Rodo, J., Grass, I., Garcia, M., Mallol, C., León, X., Casellas, A., Sánchez, V., Franckhauser, S., Ferré, T., Marcó, S. & Bosch, F., 9 Jun 2022, In: Molecular Therapy - Methods and Clinical Development. 25, p. 190-204 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Beta-Hexosaminidase Vectors
Bosch Tubert, M. F., García Martínez, M., Marcó Costa, S. & Elias Bosch, G., 7 Sept 2022, Patent No. EP22382832.8, 14 Mar 2023, Priority date 7 Sept 2022Research output: Patent