Human Diseases Models Morphological Phenotyping (MorphoPHEN)

Organisation profile

Organisation profile

Mouse-based studies are essential for the Precision Medicine, which aim to transform current
medical practice to personalized healthcare. However, the scientific community lacks sufficient
expertise in mouse morphological phenotyping to effectively characterize these animal models.
MorphoPHEN is a research group focused in mouse and human anatomy, histology, pathology, and
imaging devoted to confirm causation of identified human disease variants as pathogenic, in
particular in the area of eye diseases.
Over the next 3 years, the MorphoPHEN group will follow to validate and increase the
reproducibility of mouse human disease models. Furthermore, our group want specially to
increase the knowledge about the role of iron and iron handling proteins (TIM2 and H-ferritin)
on the pathogenesis of diabetic retinopathy. In a long term, the TIM2 deficient mouse model
developed in our laboratory could become a new model to test therapies against diabetic
retinopathy.

Research lines

  • Research lines:
  • Morphological phenotyping of mouse models for human diseases
  • Vascular pathology in metabolic and aging-related retina diseases

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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