Projects per year
Organisation profile
Organisation profile
Mouse-based studies are essential for the Precision Medicine, which aim to transform current medical practice to personalized healthcare. However, the scientific community lacks sufficient expertise in mouse morphological phenotyping to effectively characterize these animal models.
MorphoPHEN is a research group focused in mouse and human anatomy, histology, pathology, and imaging devoted to confirm causation of identified human disease variants as pathogenic, in particular in the area of eye diseases.
Over the next 3 years, the MorphoPHEN group will follow to validate and increase the reproducibility of mouse human disease models. Furthermore, our group want specially to increase the knowledge about the role of iron and iron handling proteins (TIM2 and H-ferritin) on the pathogenesis of diabetic retinopathy. In a long term, the TIM2 deficient mouse model developed in our laboratory could become a new model to test therapies against diabetic retinopathy.
Directed by:
Jesús Ruberte París
Research lines
- Research lines:
- Morphological phenotyping of mouse models for human diseases
- Vascular pathology in metabolic and aging-related retina diseases
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Collaborations and top research areas from the last five years
Profiles
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Victor Nacher Garcia
- Department of Animal Health and Anatomy - Associate Professor in Veterinary Anatomy and Embryology
- Human Diseases Models Morphological Phenotyping (MorphoPHEN)
- Centre for Animal Biotechnology and gene Therapy (CBATEG)
Person: Affiliation to research, Lecturer
Projects
- 2 Active
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IRON LYMPHATIC DRAINAGE FROM THE EYE: A NEW APPROACH TO UNDERSTAND THE PATHOPHYSIOLOGY AND TO DEVELOP NEW TREATMENTS FOR DIABETIC RETINOPATHY
Ruberte Paris, J. (Principal Investigator), Nacher Garcia, V. (Investigator), Navarro Beltran, M. (Investigator), Pampalona Sala, J. (Investigator), Gracia Arnau, G. (Collaborator), Faus Guijarro, F. (Collaborator) & Bonet, A. (Collaborator)
1/09/22 → 31/08/25
Project: Research Projects and Other Grants
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CIBERDEM: CIBERDEM_ Disfunción, destrucción, regeneración del islote Autoinmunidad
Bosch Tubert, M. F. (Principal Investigator), Barrero Victorio, J. (Investigator), Carretero Romay, A. M. (Investigator), Casaña Lorente, E. (Investigator), Casellas Comallonga, A. (Investigator), Elias Puigdomenech, I. (Investigator), Ferré Masferrer, M. D. T. (Investigator), Franckhauser Vogel, S. L. (Investigator), García Martínez, M. (Investigator), Jambrina Pallares, C. (Investigator), Jimenez, V. (Investigator), León Madrenas, X. (Investigator), Melgarejo Bermudez, V. (Investigator), Molas Laplana, M. (Investigator), Morro Larrubia, M. (Investigator), Moya Martínez, M. (Investigator), Muñoz Forero, S. A. (Investigator), Nacher Garcia, V. (Investigator), Navarro Beltran, M. (Investigator), Otaegui Goya, P. J. (Investigator), Pujol, A. (Investigator), Ribera Sanchez, A. (Investigator), Roca Lecha, C. (Investigator), Ruberte Paris, J. (Investigator), Vila Prats, L. (Investigator), Zaguirre Sánchez, M. (Investigator), Marcó Costa, S. (Investigator), Jaen Sitges, M. L. (Investigator), Sacristan Fraile, V. (Investigator) & Jaramillo Garces, S. P. (Collaborator)
1/01/09 → 31/12/30
Project: Research Projects and Other Grants
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Different anatomic patterns of the indirect tendon of the rectus femoris
Mechó, S., Iriarte, I., Lisbona, R., Pérez-Andrés, R., Pruna, R. & Rodríguez Baeza, A., Sept 2024, In: Anatomia Clinica. 46, 9, p. 1421-1428 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Pathomechanics of lumbrical and flexor digitorum profundus muscle tears in climbers : A cadaveric model
Carnicero, N., Ferreres Claramunt, À., Del Valle Jou, M., Casado, A. & Rodríguez Baeza, A., Jun 2024, In: Journal of Biomechanics. 171, 112196.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Bridging mouse and human anatomies; a knowledge-based approach to comparative anatomy for disease model phenotyping
Ruberte, J., Schofield, P. N., Sundberg, J. P., Rodríguez Baeza, A., Carretero i Romay, A. & McKerlie, C., 2023, In: Mammalian Genome. 34, p. 389-407 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus)
Datasets
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Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres
Rodrigo, M. J. (Creator), Garcia-Herranz, D. (Creator), Aragón-Navas, A. (Creator), Subias, M. (Creator), Martinez-Rincón, T. (Creator), Mendez-Martínez, S. (Creator), Cardiel, M. J. (Creator), García-Feijoo, J. (Creator), Ruberte Paris, J. (Creator), Herrero-Vanrell, R. (Creator), Pablo, L. (Creator), Garcia-Martin, E. (Creator) & Bravo-Osuna, I. (Creator), 12 Nov 2021
DOI: 10.6084/m9.figshare.16998284.v1, https://tandf.figshare.com/articles/dataset/Long-term_corticosteroid-induced_chronic_glaucoma_model_produced_by_intracameral_injection_of_dexamethasone-loaded_PLGA_microspheres/16998284/1
Dataset
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Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres
Rodrigo, M. J. (Creator), Garcia-Herranz, D. (Creator), Aragón-Navas, A. (Creator), Subias, M. (Creator), Martinez-Rincón, T. (Creator), Mendez-Martínez, S. (Creator), Cardiel, M. J. (Creator), García-Feijoo, J. (Creator), Ruberte, J. (Creator), Herrero-Vanrell, R. (Creator), Pablo, L. (Creator), Garcia-Martin, E. (Creator) & Bravo-Osuna, I. (Creator), 12 Nov 2021
DOI: 10.6084/m9.figshare.16998284, https://tandf.figshare.com/articles/dataset/Long-term_corticosteroid-induced_chronic_glaucoma_model_produced_by_intracameral_injection_of_dexamethasone-loaded_PLGA_microspheres/16998284
Dataset
Student theses
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Analysis of TIM2 deficiency in the mouse retina
Barbosa Valença, A. (Author), Ruberte Paris, J. (Director) & Mendes-Jorge, L. (Co-director), 2019Student thesis: Doctoral thesis
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Implicaciones de p16INK4a y SIRT1 en la formación de microaneurismas en las retinas humanas durante el envejecimiento.
Lopez Luppo, M. (Author), Ruberte Paris, J. (Director) & Nacher Garcia, V. (Co-director), 2012Student thesis: Doctoral thesis
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Uso de técnicas de imagen en el fenotipado cardiovascular del ratón
Domínguez Miño, E. A. (Author), Espada Gerlach, Y. (Director) & Ruberte Paris, J. (Director), 2011Student thesis: Doctoral thesis