Organisation profile
Organisation profile
The research group is focused on defining and applying gene therapy strategies for the treatment of diseases that affect the Nervous System such as neurodegenerative and neurometabolic diseases, as well as in the study of the molecular mechanisms involved in the development and progression of pathological processes. This main objective is defined in 3 main lines: 1.- Development of gene therapy strategies for rare diseases affecting the central nervous system. 2.- Study of the molecular mechanisms involved in cognitive deficits in aging and Alzheimer's. 3.- Development, generation, and production of gene therapy vectors.
Directed by:
Assumpció Bosch
Research lines
- Research lines:
- Gene therapy for rare diseases affecting the central nervous system (spastic paraplegia type 52 -SPG52-, GNB1 encephalopathy, megalencephalic leukoencephalopathy with subcortical cysts -MLC-, Wolfram syndrome, amyotrophic lateral sclerosis -ALS-, and Rett's syndrome) using AAV vectors.
- Study of molecular mechanisms involved in cognitive deficits associated with aging and Alzheimer's disease.
- Generation and production of viral vectors for gene therapy; Development of viral vectors.
Fingerprint
Collaborations and top research areas from the last five years
Profiles
-
Assumpció Bosch
- Department of Biochemistry and Molecular Biology
- Gene therapy for diseases involving the central nervous system- TherCNS
- Institute of Neuroscience (INc)
Person: Affiliation to research, Professor (non-goverment employee)
-
Lidia Gimenez Llort
- Department of Psychiatry and Legal Medicine
- Gene therapy for diseases involving the central nervous system- TherCNS
- Institute of Neuroscience (INc)
Person: Affiliation to research, Professor (non-goverment employee)
-
María Page Galocha
- Department of Biochemistry and Molecular Biology
- Gene therapy for diseases involving the central nervous system- TherCNS
Person: Affiliation to research, Pre-doctoral researcher training
-
Estrategia preclínica de Terapia Génica para el Síndrome de Wolfram
Bosch, A. (Principal Investigator), Benjamin Delprat (Collaborator), Camprodon Gomez, M. (Collaborator), Consiglio, A. (Collaborator), Del Toro Riera, M. (Collaborator), Miravet Delgado, S. (Collaborator), Page Galocha, M. (Collaborator), Chillón Rodriguez, M. (Investigator) & Sanchez Osuna, A. (Investigator)
1/04/25 → 30/09/26
Project: Research Projects and Other Grants
-
HUMANIZED MOUSE TO ASSESS THE CONTRIBUTION OF MICROGLIA IN FAMILIAR FORMS OF AMYOTROPHIC LATERAL SCLEROSIS
Lopez Vales, R. (Principal Investigator), Hernández Martín, J. (Co-Investigador/a Principal), Caro Cantón, M. (Collaborator), Garcia Garcia, J. (Collaborator), Hernandez Solanes, N. (Collaborator), Lopez Gonzalez, N. (Collaborator), Guerrero Yague, R. (Collaborator) & Marin Ferrer Egea, J. (Collaborator)
1/09/24 → 31/12/27
Project: Research Projects and Other Grants
-
THERAPEUTICAL MODULATION OF THE MICROGLIA-NEURONAL INTERACTION BY CHRONOKINES TO TREAT CHRONIC BRAIN INFLAMMATION ASSOCIATED WITH AGING
Almolda Ardid, B. (Principal Investigator), Chillón Rodriguez, M. (Co-Investigador/a Principal), Esandi Jaúregui, J. (Collaborator), Lunar Roldan, J. (Collaborator), Miravet Delgado, S. (Collaborator), Rey Azpiri, J. D. (Collaborator), Rubio i Ortega, L. (Collaborator) & Ramirez Gomez, D. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
-
Premature Neuroimmune and Redox-Inflammatory Breakdown at the Prodromal Stage in Male and Female Triple-Transgenic Alzheimer's Disease Mice
Gimenez-Llort, L., Vida, C., Félix, J., Quer-Palomas, S., De la Fuente, M. & Manassra, R., 2026, In: Diseases. 14, 2Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A Systematic Review on Subjective Cognitive Complaints : Main Neurocognitive Domains, Myriad Assessment Tools, and New Approaches for Early Detection
Webster-Cordero, F. & Gimenez-Llort, L., 9 May 2025, In: Geriatrics (Switzerland). 10, 3, 14 p., 65.Research output: Contribution to journal › Review article › Research › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
Erratum: Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience
Roig-Soriano, J., EDO SALVADOR, A., Verdés, S., Martín-Alonso, C., Sánchez-de-Diego, C., Rodriguez-Estevez, L., Serrano, A. L., Abraham, C. R., Bosch, A., Ventura, F., Jordan, B. A., Muñoz-Cánoves, P. & Chillon, M., 6 Aug 2025, In: Molecular Therapy. 33, 8, p. 4007-4007 1 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Student theses
-
Study of the neurodegenerative process in Mucopolysaccharidosis type VII and its correction by gene therapy
Onieva Salgado, A. (Author), Bosch, A. (Director) & Sanchez Osuna, A. (Director), 11 May 2023Student thesis: Doctoral thesis