Projects per year
Organisation profile
Organisation profile
The research group is focused on defining and applying gene therapy strategies for the treatment of diseases that affect the Nervous System such as neurodegenerative and neurometabolic diseases, as well as in the study of the molecular mechanisms involved in the development and progression of pathological processes. This main objective is defined in 3 main lines: 1.- Development of gene therapy strategies for rare diseases affecting the central nervous system. 2.- Study of the molecular mechanisms involved in cognitive deficits in aging and Alzheimer's. 3.- Development, generation, and production of gene therapy vectors.
Directed by:
Assumpció Bosch
Research lines
- Research lines:
- Gene therapy for rare diseases affecting the central nervous system (spastic paraplegia type 52 -SPG52-, GNB1 encephalopathy, megalencephalic leukoencephalopathy with subcortical cysts -MLC-, Wolfram syndrome, amyotrophic lateral sclerosis -ALS-, and Rett's syndrome) using AAV vectors.
- Study of molecular mechanisms involved in cognitive deficits associated with aging and Alzheimer's disease.
- Generation and production of viral vectors for gene therapy; Development of viral vectors.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Assumpció Bosch
- Department of Biochemistry and Molecular Biology
- Gene therapy for diseases involving the central nervous system- TherCNS
- Institute of Neuroscience (INc)
Person: Affiliation to research, Professor (non-goverment employee)
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Alejandro Brao Gonzalez
- Department of Biochemistry and Molecular Biology
- Gene therapy for diseases involving the central nervous system- TherCNS
Person: University Training FPU, Affiliation to research
Projects
- 3 Active
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Defining a Minimal Human Endogenous Promoter for Safe and Efficient Gene Therapy to Treat MLC
Bosch, A. (Principal Investigator), Chillón Rodriguez, M. (Investigator), Sanchez Osuna, A. (Investigator), Brao Gonzalez, A. (Predoctoral), Rodriguez Reverte, I. (Predoctoral) & Miravet Delgado, S. (Technician)
1/01/25 → 31/12/25
Project: International research project
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HUMANIZED MOUSE TO ASSESS THE CONTRIBUTION OF MICROGLIA IN FAMILIAR FORMS OF AMYOTROPHIC LATERAL SCLEROSIS
Lopez Vales, R. (Principal Investigator), Hernández Martín, J. (Co-Investigador/a Principal), Caro Cantón, M. (Collaborator), Garcia Garcia, J. (Collaborator), Hernandez Solanes, N. (Collaborator), Lopez Gonzalez, N. (Collaborator) & Guerrero Yague, R. (Collaborator)
1/09/24 → 31/12/27
Project: Research Projects and Other Grants
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THERAPEUTICAL MODULATION OF THE MICROGLIA-NEURONAL INTERACTION BY CHRONOKINES TO TREAT CHRONIC BRAIN INFLAMMATION ASSOCIATED WITH AGING
Almolda Ardid, B. (Principal Investigator), Chillón Rodriguez, M. (Co-Investigador/a Principal), Esandi Jaúregui, J. (Collaborator), Lunar Roldan, J. (Collaborator), Miravet Delgado, S. (Collaborator), Rey Azpiri, J. D. (Collaborator), Rubio i Ortega, L. (Collaborator) & Ramirez Gomez, D. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
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Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts
Brao, A., Sanchez, A., Rodríguez, I., Rey, J. D., Lope-Piedrafita, S., Prat, E., Nunes, V., Chillon, M., Estévez, R. & Bosch, A., 2 Apr 2025, In: Molecular Therapy. 33, 4, p. 1434-1448 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease
Esandi, J., Renault, P., Capilla-López, M. D., Blanch, R., Edo, Á., Ramirez-Gómez, D., Bosch, A., Almolda, B., Saura, C. A., Giraldo, J. & Chillón, M., Feb 2025, In: Biomedicine and Pharmacotherapy. 183, 13 p., 117815.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Long-term effects of s-KL treatment in wild-type mice: enhancing longevity, physical well-being, and neurological resilience
Roig-Soriano, J., Edo, Á., Verdés, S., Martín-Alonso, C., Sánchez-de-Diego, C., Rodriguez-Estevez, L., Serrano, A. L., Abraham, C. R., Bosch, A., Ventura, F., Jordan, B. A., Muñoz-Cánoves, P. & Chillón, M., 2 Apr 2025, In: Molecular Therapy. 33, 4, p. 1449-1465 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Student theses
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Study of the neurodegenerative process in Mucopolysaccharidosis type VII and its correction by gene therapy
Onieva Salgado, A. (Author), Bosch, A. (Director) & Sanchez Osuna, A. (Director), 11 May 2023Student thesis: Doctoral thesis