Projects per year
Organisation profile
Organisation profile
The research group is focused on defining and applying gene therapy strategies for the treatment of diseases that affect the Nervous System such as neurodegenerative and neurometabolic diseases, as well as in the study of the molecular mechanisms involved in the development and progression of pathological processes. This main objective is defined in 3 main lines: 1.- Development of gene therapy strategies for rare diseases affecting the central nervous system. 2.- Study of the molecular mechanisms involved in cognitive deficits in aging and Alzheimer's. 3.- Development, generation, and production of gene therapy vectors.
Directed by:
Assumpció Bosch
Research lines
- Research lines:
- Gene therapy for rare diseases affecting the central nervous system (spastic paraplegia type 52 -SPG52-, GNB1 encephalopathy, megalencephalic leukoencephalopathy with subcortical cysts -MLC-, Wolfram syndrome, amyotrophic lateral sclerosis -ALS-, and Rett's syndrome) using AAV vectors.
- Study of molecular mechanisms involved in cognitive deficits associated with aging and Alzheimer's disease.
- Generation and production of viral vectors for gene therapy; Development of viral vectors.
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Assumpció Bosch
- Department of Biochemistry and Molecular Biology
- Gene therapy for diseases involving the central nervous system- TherCNS
- Institute of Neuroscience (INc)
Person: Professor (non-goverment employee), Assignment to research
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Alejandro Brao Gonzalez
- Department of Biochemistry and Molecular Biology
- Gene therapy for diseases involving the central nervous system- TherCNS
Person: University Training FPU 3-4, Assignment to research
Projects
- 1 Active
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THERAPEUTICAL MODULATION OF THE MICROGLIA-NEURONAL INTERACTION BY CHRONOKINES TO TREAT CHRONIC BRAIN INFLAMMATION ASSOCIATED WITH AGING
Almolda Ardid, B. (Principal Investigator), Chillón Rodriguez, M. (Principal Investigator 2), Esandi Jaúregui, J. (Collaborator), Lunar Roldan, J. (Collaborator), Miravet Delgado, S. (Collaborator), Rey Azpiri, J. D. (Collaborator) & Rubio i Ortega, L. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
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Design and effectiveness of an online group logotherapy intervention on the mental health of Iranian international students in European countries during the COVID-19 pandemic
Rahgozar, S. & Gimenez-Llort, L., 21 Feb 2024, In: Frontiers in Psychiatry. 15, 1323774.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Food Finding Test without Deprivation : A Sensorial Paradigm Sensitive to Sex, Genotype, and Isolation Shows Signatures of Derangements in Old Mice with Alzheimer's Disease Pathology and Normal Aging
Marín-Pardo, D. & Gimenez-Llort, L., 18 Mar 2024, In: Brain Sciences. 14, 3, 288.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Glomerular Hypertrophy and Splenic Red Pulp Degeneration Concurrent with Oxidative Stress in 3xTg-AD Mice Model for Alzheimer's Disease and Its Exacerbation with Sex and Social Isolation
Fraile-Ramos, J., Reig Vilallonga, J. & Gimenez-Llort, L., 1 Jun 2024, In: International Journal of Molecular Sciences. 25, 11, 17 p., 6112.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Student theses
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Study of the neurodegenerative process in Mucopolysaccharidosis type VII and its correction by gene therapy
Onieva Salgado, A. (Author)Bosch, A. (Director) & Sanchez Osuna, A. (Director), 11 May 2023Student thesis: Doctoral thesis