Projects per year
Organisation profile
Organisation profile
To promote responsible research, knowledge transfer to public and to private sectors as well as to train a new generation of highly qualified scientists in the cross-disciplinary field of Industrial and Medical Biotechnology (white and red biotechnology). Specifically, the main objective is to develop sustainable biotechnological processes intensified and optimized to obtain products of interest for the chemical, pharma, medical, food and health industries and
to provide real-time analytical monitoring to improve the quality of products and processes. The research interests are focused on 1) microbial production of recombinant proteins and low molecular weight molecules 2) vaccines, proteins for diagnostic and gene and cells therapies, 3) multi-enzymatic processes including stereo selective synthesis 4) Integrating Process Analytical Technology (PAT), Quality by Design (QbD), internet of things (IoT), and artificial intelligence (AI), considered as key technologies in the industry 4.0
Directed by:
Francisco Valero Barranco
Research lines
- Research lines:
- Biological systems engineering of bacteria and yeasts for the production of recombinant proteins and metabolites of industrial interest
- Bioprocess and Applied Biocatalysis Engineering
- Cell culture-based bioprocesses for biopharmaceutical production
- Development of pilot-scale fermentation processes
- Real-time process monitoring using rapid instrumental techniques and multivariate data processing
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being -
SDG 5 Gender Equality -
SDG 6 Clean Water and Sanitation -
SDG 7 Affordable and Clean Energy -
SDG 8 Decent Work and Economic Growth -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 11 Sustainable Cities and Communities -
SDG 12 Responsible Consumption and Production -
SDG 13 Climate Action -
SDG 14 Life Below Water -
SDG 16 Peace, Justice and Strong Institutions
Fingerprint
Dive into the research topics where Enginyeria de Bioprocessos i Biocatàlisi Aplicada. (ENG4BIO) is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Joan Albiol Sala
- Department of Chemical, Biological and Environmental Engineering
- Enginyeria de Bioprocessos i Biocatàlisi Aplicada. (ENG4BIO)
Person: Affiliation to research, Associate lecturer (non-goverment employee)
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Maria Dolors Benaiges Massa
- Department of Chemical, Biological and Environmental Engineering
- Enginyeria de Bioprocessos i Biocatàlisi Aplicada. (ENG4BIO)
Person: Affiliation to research, Lecturer
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Circular Carbon Utilization via Multi-catalytic Biobased platform
Guillen Montalban, M. (Principal Investigator), Romero Ormazábal, O. E. (Co-Investigador/a Principal), Casablancas Mira, A. (Investigator), Bonet Ragel, K. (Investigator), Guerra Mas, G. (Collaborator), Dimitri Gómez, I. (Collaborator), Fredes Tapia, Y. A. (Collaborator), Estrada Veliz, R. A. (Collaborator) & Clavero Acevedo, C. A. (Collaborator)
1/09/26 → 31/08/30
Project: Research Projects and Other Grants
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Desarrollo de vainillina natural mediante una nueva via enzimática a partir de subproductos agrícolas
Guillen Montalban, M. (Principal Investigator), Casablancas Mira, A. (Investigator), Romero Ormazabal, O. E. (Investigator) & Valero Barranco, F. (Investigator)
Spanish Ministry of Science, Innovation and Universities, European Regional Development Fund (FEDER)
1/11/25 → 31/10/28
Project: Research Projects and Other Grants
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DEBOTTLENECKING AND DEPLOYING NOVEL MULTI-ENZYMATIC SYSTEMS FOR INDUSTRIAL BIO-BASED PROCESSES
Guillen Montalban, M. (Principal Investigator), Romero Ormazabal, O. E. (Co-Investigador/a Principal), Concha Nuñez, D. C. (Collaborator), Fredes Tapia, Y. A. (Collaborator), Guerra Mas, G. (Collaborator), Muñoz Sánchez, D. (Collaborator), Rodriguez Avila, S. R. (Collaborator), Alvaro Campos, G. (Investigator), Caminal Saperas, G. (Investigator), Casablancas Mira, A. (Investigator), Gonzalez Anadon, G. (Investigator), Ortiz de Orruño Cuesta, G. (Collaborator), Bonet Ragel, K. (Investigator) & Dimitri Gómez, I. (Collaborator)
1/09/23 → 31/08/27
Project: Research Projects and Other Grants
Research output
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Biotecnología industrial (White Biotechnology) e ingeniería química
Valero Barranco, F., 2026, Una historia parcial de 50 años de Ingeniería Química en España. Recopilación en Homenaje al profesor Mario Díaz. Rendueles de la Vega, M., Laca Pérez, A., Collado Alonso, S., Oulego Blanco, P., Laca Pérez, A. & Marcet, I. (eds.). Universidad de Oviedo, p. 175-180 5 p.Research output: Chapter in Book › Chapter › Research › peer-review
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Carbohydrate concentration and type drive product selectivity to a mixture of volatile fatty acids or lactic acid in thermophilic mixed-culture fermentation
Vulart Bach, L., Izcara, N., Estévez, Á., Peiro Cezon, E. E., Gòdia, F. & Ganigué, R., Dec 2026, In: Applied Microbiology and Biotechnology. 110, 1, 143.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Enzyme-Powered CO₂ Utilization : A Bifunctional Immobilized Biocatalyst for Intensified CCU of Industrial Feedstocks to High-Value Chemicals
Rodriguez Avila, S. R., Romero, O. & Guillén, M., 12 Jan 2026, In: ACS Sustainable Chemistry and Engineering. 14, 1, p. 86-98 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus)
Datasets
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Replication data for "Synergic kinetic and physiological control to improve the efficiency of Komagataella phaffii recombinant protein production bioprocesses"
Sales Vallverdu, A. (Creator), Gasset Franch, A. (Creator), Requena Moreno, G. (Creator), Valero Barranco, F. (Creator), Montesinos Segui, J. L. (Creator) & Garcia-Ortega, X. (Creator), CORA.Repositori de Dades de Recerca, 1 Apr 2024
DOI: 10.34810/data1118
Dataset
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Supplementary materials of research article "High throughput 13C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux
Fina Romero, A. (Creator), Millard, P. (Creator), Albiol Sala, J. (Creator), Ferrer Alegre, P. (Creator) & Heux, S. (Creator), CORA.Repositori de Dades de Recerca, 6 Mar 2023
DOI: 10.34810/data673, https://dataverse.csuc.cat/dataset.xhtml?persistentId=doi:10.34810/data673
Dataset
Student theses
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Development of antibody-based antitumor therapies based on trastuzumab: antibody-drug conjugates, immunocytokines and fragment conjugates.
Miret Minard, J. (Author), Casablancas Mira, A. (Director), Cairo Badillo, J. J. (Director), Cairo Badillo, J. J. (Tutor) & Lecina Veciana, M. (Director), 21 Oct 2019Student thesis: Doctoral thesis
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Disseny, clonatge i expressió del gen lip2 de Candiad rugosa en Pichia pastoris.
Màrius Tomàs Gamisans (Author), Ferrer Alegre, P. (Director) & Valero Barranco, F. (Director), 25 Jul 2012Student thesis: Dissertation (TFM)
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Diseño, clonaje y expresión del gen de la lipasa B de Candida antarctica (CalB) en Pichia pastoris.
Santiago Barreiro Vescoso. (Author), Ferrer Alegre, P. (Director) & Valero Barranco, F. (Director), 22 Jul 2014Student thesis: Dissertation (TFM)