Projects per year
Organisation profile
Organisation profile
To promote responsible research, knowledge transfer to public and to private sectors as well as to train a new generation of highly qualified scientists in the cross-disciplinary field of Industrial and Medical Biotechnology (white and red biotechnology). Specifically, the main objective is to develop sustainable biotechnological processes intensified and optimized to obtain products of interest for the chemical, pharma, medical, food and health industries and
to provide real-time analytical monitoring to improve the quality of products and processes. The research interests are focused on 1) microbial production of recombinant proteins and low molecular weight molecules 2) vaccines, proteins for diagnostic and gene and cells therapies, 3) multi-enzymatic processes including stereo selective synthesis 4) Integrating Process Analytical Technology (PAT), Quality by Design (QbD), internet of things (IoT), and artificial intelligence (AI), considered as key technologies in the industry 4.0
Directed by:
Francisco Valero Barranco
Research lines
- Research lines:
- Biological systems engineering of bacteria and yeasts for the production of recombinant proteins and metabolites of industrial interest
- Bioprocess and Applied Biocatalysis Engineering
- Cell culture-based bioprocesses for biopharmaceutical production
- Development of pilot-scale fermentation processes
- Real-time process monitoring using rapid instrumental techniques and multivariate data processing
Fingerprint
Collaborations and top research areas from the last five years
Profiles
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Joan Albiol Sala
- Department of Chemical, Biological and Environmental Engineering
- Enginyeria de Bioprocessos i Biocatàlisi Aplicada. (ENG4BIO)
Person: Associate lecturer (non-goverment employee), Affiliation to research
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Maria Dolors Benaiges Massa
- Department of Chemical, Biological and Environmental Engineering
- Enginyeria de Bioprocessos i Biocatàlisi Aplicada. (ENG4BIO)
Person: Affiliation to research, Lecturer
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TOWARDS SMART BIOMANUFACTURING 4.0 OF RECOMBINANT PROTEIN PRODUCTION PROCESSES IN YEAST CELL FACTORIES
Valero Barranco, F. (Principal Investigator), Ferrer Alegre, P. (Co-Investigador/a Principal), Anton Garcia, E. (Collaborator), Avila Cabre, S. (Collaborator), Bernat Camps, N. (Collaborator), Sales Vallverdu, A. (Collaborator), Vazquez Lima, F. (Collaborator), Vázquez Pereira, E. (Collaborator), Albiol Sala, J. (Investigator), Benaiges Massa, M. D. (Investigator), Garcia-Ortega, X. (Investigator), Montesinos Segui, J. L. (Investigator), Requena Moreno, G. (Collaborator) & Lopez Grado i Salinas, G. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
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VIRUS LIKE PARTICLES AS MICROCARRIERS OF MOLECULES WITH BIOLOGICAL FUNCTIONALITY
Godia Casablancas, F. (Principal Investigator), Bosch Molist, L. (Collaborator), García Trujillo, M. (Collaborator), Lorenzo Romero, E. (Collaborator), Perez Rubio, P. (Collaborator) & Cervera Gracia, L. (Investigator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
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DEBOTTLENECKING AND DEPLOYING NOVEL MULTI-ENZYMATIC SYSTEMS FOR INDUSTRIAL BIO-BASED PROCESSES
Guillen Montalban, M. (Principal Investigator), Romero Ormazabal, O. E. (Co-Investigador/a Principal), Concha Nuñez, D. C. (Collaborator), Fredes Tapia, Y. A. (Collaborator), Guerra Mas, G. (Collaborator), Muñoz Sánchez, D. (Collaborator), Rodriguez Avila, S. R. (Collaborator), Alvaro Campos, G. (Investigator), Caminal Saperas, G. (Investigator), Casablancas Mira, A. (Investigator), Gonzalez Anadon, G. (Investigator), Ortiz de Orruño Cuesta, G. (Collaborator), Bonet Ragel, K. (Investigator) & Dimitri Gómez, I. (Collaborator)
1/09/23 → 31/08/26
Project: Research Projects and Other Grants
Research output
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Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol
Àvila-Cabré, S., Albiol, J. & Ferrer, P., 20 Feb 2025, In: Journal of Biological Engineering. 19, 1, 16 p., 19.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Multienzymatic Platform for Coupling a CCU Strategy to Waste Valorization: CO2 from the Iron and Steel Industry and Crude Glycerol from Biodiesel Production
Rodriguez Avila, S. R., Alvaro Campos, G., Guillen Montalban, M. & Romero Ormazabal, O. E., 17 Jan 2025, In: ACS Sustainable Chemistry and Engineering. 13, 4, p. 1440-1449 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)4 Downloads (Pure) -
Targeted knockdown of ATM, ATR, and PDEδ increases Gag HIV-1 VLP production in HEK293 cells
Pérez-Rubio, P., Rigau Granes, C., Bosch Molist, L., Gòdia, F. & Cervera Gracia, L., 2 Jan 2025, In: Applied Microbiology and Biotechnology. 109, 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Datasets
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Supplementary materials of research article "High throughput 13C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux
Fina Romero, A. (Creator), Millard, P. (Creator), Albiol Sala, J. (Creator), Ferrer Alegre, P. (Creator) & Heux, S. (Creator), CORA.Repositori de Dades de Recerca, 6 Mar 2023
DOI: 10.34810/data673, https://dataverse.csuc.cat/dataset.xhtml?persistentId=doi:10.34810/data673
Dataset
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MOESM1 of Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) PAOX1-driven recombinant producer strains with different target gene dosage
Garrigos Martinez, J. (Creator), Nieto Taype, M. A. (Creator), Gasset Franch, A. (Creator), Montesinos-Seguí, J. L. (Creator), Garcia-Ortega, X. (Creator) & Valero, F. (Creator), figshare, 1 Nov 2019
DOI: 10.6084/m9.figshare.10184630.v1, https://springernature.figshare.com/articles/MOESM1_of_Specific_growth_rate_governs_AOX1_gene_expression_affecting_the_production_kinetics_of_Pichia_pastoris_Komagataella_phaffii_PAOX1-driven_recombinant_producer_strains_with_different_target_gene_dosage/10184630/1
Dataset
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Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris
Garrigos Martinez, J. (Creator), Vuoristo, K. (Creator), Nieto Taype, M. A. (Creator), Tähtiharju, J. (Creator), Uusitalo, J. (Creator), Tukiainen, P. (Creator), Schmid, C. (Creator), Tolstorukov, I. (Creator), Madden, K. (Creator), Penttilä, M. (Creator), Montesinos-Seguí, J. L. (Creator), Valero, F. (Creator), Glieder, A. (Creator) & Garcia-Ortega, X. (Creator), figshare, 23 Mar 2021
DOI: 10.6084/m9.figshare.c.5350849.v1, https://springernature.figshare.com/collections/Bioprocess_performance_analysis_of_novel_methanol-independent_promoters_for_recombinant_protein_production_with_Pichia_pastoris/5350849/1
Dataset
Student theses
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Condiciones limitantes de oxígeno para mejorar la producción de proteínas recombinantes en Pichia pastoris reguladas bajo el promotor GAP
Hierro Iglesias, C. (Author), Montesinos Segui, J. L. (Director) & Garcia Ortega, X. (Director), 16 Jul 2019Student thesis: Dissertation (TFM)
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Definición y utilización de técnicas de control en el proceso de producción de lipasas por Candida rugosa
Sanz Alvarez, A. (Author), Montesinos Segui, J. L. (Director) & Lafuente Sancho, F. J. (Director), 22 Sept 1995Student thesis: Dissertation (TFM)
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Multidisciplinary approach for recombinant protein production bioprocess design with clàssic and novel expression Systems in Pichia pastoris
Garrigos Martinez, J. (Author), Montesinos Segui, J. L. (Director), Garcia Ortega, X. (Director) & Valero Barranco, F. (Director), 12 Jan 2021Student thesis: Doctoral thesis