Dataset related to the article "CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry"

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This record contains raw data related to the article “CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: an international Registry”


Abstract

Aims: The aim of this registry was to evaluate the additional prognostic value of a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in a large cohort of consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.

Methods and results: In the DERIVATE registry (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation cohort) NICM patients with chronic heart failure (HF) and left ventricular ejection fraction 3 segments with midwall fibrosis on late gadolinium enhancement (LGE) were the only independent predictors of all-cause mortality (HR: 1.036, 95% CI: 1.0117-1.056, P < 0.001 and HR: 2.077, 95% CI: 1.211-3.562, P = 0.008, respectively). For MAACE, the independent predictors were male gender, left ventricular end-diastolic volume index by CMR (CMR-LVEDVi), and >3 segments with midwall fibrosis on LGE (HR: 2.131, 95% CI: 1.231-3.690, P = 0.007; HR: 3.161, 95% CI: 1.750-5.709, P < 0.001; and HR: 1.693, 95% CI: 1.084-2.644, P = 0.021, respectively). A composite clinical and CMR-based risk score provided a net reclassification improvement of 63.7% (P < 0.001) for MAACE occurrence when added to the model based on SOC evaluation. These findings were confirmed in the validation cohort.

Conclusion: In a large multicentre, multivendor cohort registry reflecting daily clinical practice in NICM work-up, a composite clinical and CMR-based risk score provides incremental prognostic value beyond SOC evaluation, which may have impact on the indication of implantable cardioverter-defibrillator implantation.
Date made available27 Jan 2022
PublisherZenodo

  • CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy in Non-Ischaemic dilated CardioMyopathy: An international Registry

    Guaricci, A. I., Masci, P. G., Muscogiuri, G., Guglielmo, M., Baggiano, A., Fusini, L., Lorenzoni, V., Martini, C., Andreini, D., Pavon, A. G., Aquaro, G. D., Barison, A., Todiere, G., Rabbat, M. G., Tat, E., Raineri, C., Valentini, A., Varga-Szemes, A., Schoepf, U. J. & De Cecco, C. N. & 30 others, Bogaert, J., Dobrovie, M., Symons, R., Focardi, M., Gismondi, A., Lozano-Torres, J., Rodriguez-Palomares, J. F., Lanzillo, C., Di Roma, M., Moro, C., Di Giovine, G., Margonato, D., De Lazzari, M., Perazzolo Marra, M., Nese, A., Casavecchia, G., Gravina, M., Marzo, F., Carigi, S., Pica, S., Lombardi, M., Censi, S., Squeri, A., Palumbo, A., Gaibazzi, N., Camastra, G., Sbarbati, S., Pedrotti, P., Masi, A. & Carrabba, N., 1 Jul 2021, In: Europace. 23, 7, p. 1072-1083 12 p.

    Research output: Contribution to journal › Article › Research › peer-review

    49 Citations (Scopus)

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