TY - JOUR
T1 - Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells
AU - Gener, Petra
AU - Montero, Sara
AU - Xandri-Monje, Helena
AU - Díaz-Riascos, Zamira V.
AU - Rafael, Diana
AU - Andrade, Fernanda
AU - Martínez-Trucharte, Francesc
AU - González, Patricia
AU - Seras-Franzoso, Joaquin
AU - Manzano, Albert
AU - Arango, Diego
AU - Sayós, Joan
AU - Abasolo, Ibane
AU - Schwartz, Simo
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2020/2
Y1 - 2020/2
N2 - Tumor recurrence, metastatic spread and progressive gain of chemo-resistance of advanced cancers are sustained by the presence of cancer stem cells (CSCs) within the tumor. Targeted therapies with the aim to eradicate these cells are thus highly regarded. However, often the use of new anti-cancer therapies is hampered by pharmacokinetic demands. Drug delivery through nanoparticles has great potential to increase efficacy and reduce toxicity and adverse effects. However, its production has to be based on intelligent design. Likewise, we developed polymeric nanoparticles loaded with Zileuton™, a potent inhibitor of cancer stem cells (CSCs), which was chosen based on high throughput screening. Its great potential for CSCs treatment was subsequently demonstrated in in vitro and in in vivo CSC fluorescent models. Encapsulated Zileuton™ reduces amount of CSCs within the tumor and effectively blocks the circulating tumor cells (CTCs) in the blood stream and metastatic spread.
AB - Tumor recurrence, metastatic spread and progressive gain of chemo-resistance of advanced cancers are sustained by the presence of cancer stem cells (CSCs) within the tumor. Targeted therapies with the aim to eradicate these cells are thus highly regarded. However, often the use of new anti-cancer therapies is hampered by pharmacokinetic demands. Drug delivery through nanoparticles has great potential to increase efficacy and reduce toxicity and adverse effects. However, its production has to be based on intelligent design. Likewise, we developed polymeric nanoparticles loaded with Zileuton™, a potent inhibitor of cancer stem cells (CSCs), which was chosen based on high throughput screening. Its great potential for CSCs treatment was subsequently demonstrated in in vitro and in in vivo CSC fluorescent models. Encapsulated Zileuton™ reduces amount of CSCs within the tumor and effectively blocks the circulating tumor cells (CTCs) in the blood stream and metastatic spread.
KW - Cancer stem cells (CSC)
KW - Circulating tumor tells (CTC)
KW - Nanomedicine
KW - Polymeric micelles
KW - Zileuton™
UR - http://www.scopus.com/inward/record.url?scp=85074730067&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2019.102106
DO - 10.1016/j.nano.2019.102106
M3 - Article
C2 - 31666201
AN - SCOPUS:85074730067
SN - 1549-9634
VL - 24
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
M1 - 102106
ER -
