TY - JOUR
T1 - Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp.
AU - Grau, S.
AU - Luque, S.
AU - Echeverría-Esnal, D.
AU - Sorlí, L.
AU - Campillo, N.
AU - Montero, M.
AU - Álvarez Lerma, F.
AU - Plasencia, V.
AU - Horcajada, J. P.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - © 2016 Elsevier B.V. and International Society of Chemotherapy Six cases of patients diagnosed with urinary tract infection (UTI) successfully treated with micafungin are reported. Four were infected with fluconazole-resistant Candida spp. and two (with hepatic injury) were infected with fluconazole-sensitive Candida spp. Traditionally, echinocandins have not been considered for the treatment of UTIs. However, despite its low urinary excretion rate, therapeutic drug monitoring of micafungin urinary levels could be helpful in order to achieve optimal pharmacokinetic/pharmacodynamic (PK/PD) indices for treating UTIs caused by Candida spp. resistant to fluconazole.
AB - © 2016 Elsevier B.V. and International Society of Chemotherapy Six cases of patients diagnosed with urinary tract infection (UTI) successfully treated with micafungin are reported. Four were infected with fluconazole-resistant Candida spp. and two (with hepatic injury) were infected with fluconazole-sensitive Candida spp. Traditionally, echinocandins have not been considered for the treatment of UTIs. However, despite its low urinary excretion rate, therapeutic drug monitoring of micafungin urinary levels could be helpful in order to achieve optimal pharmacokinetic/pharmacodynamic (PK/PD) indices for treating UTIs caused by Candida spp. resistant to fluconazole.
KW - Candida spp
KW - Fluconazole-resistant
KW - Micafungin
KW - Urinary tract infection
U2 - 10.1016/j.ijantimicag.2016.05.010
DO - 10.1016/j.ijantimicag.2016.05.010
M3 - Article
SN - 0924-8579
VL - 48
SP - 212
EP - 214
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 2
ER -