TY - JOUR
T1 - Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis
AU - Robin, Marie
AU - Giannotti, Federica
AU - Deconinck, Eric
AU - Mohty, Mohamad
AU - Michallet, Mauricette
AU - Sanz, Guillermo
AU - Chevallier, Patrice
AU - Cahn, Jean-Yves
AU - Legrand, Faezeh
AU - Rovira, Montserrat
AU - Passweg, Jakob
AU - Sierra, Jorge
AU - Nguyen, Stephanie
AU - Maillard, Natacha
AU - Yakoub-Agha, Ibrahim
AU - Linkesch, Werner
AU - Cannell, Paul
AU - Marcatti, Magda
AU - Bay, Jacques Olivier
AU - Chalandon, Yves
AU - Kröger, Nicolaus
AU - Gluckman, Eliane
AU - Rocha, Vanderson
AU - Olavarria, Eduardo
AU - Ruggeri, Annalisa
PY - 2014
Y1 - 2014
N2 - To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. The median follow-up was 24 months. The cumulative incidence of neutrophil recovery at 60 days was 80%. Fifteen patients relapsed after UCBT. The 2-year overall survival and event-free-survival (EFS) rates were 44% and 30%, respectively. All patients given TCF achieved neutrophil and platelet recovery, and the use of TCF was associated with superior EFS in the RIC population (44% versus 0%, P=.001). Patients with transformation to AML had similar outcomes to patients with less advanced stages. In conclusion, despite graft failure remaining a major concern, the role of UCBT in the management of MF, especially using RIC TCF-based regimens, deserves further investigation to improve results.
AB - To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. The median follow-up was 24 months. The cumulative incidence of neutrophil recovery at 60 days was 80%. Fifteen patients relapsed after UCBT. The 2-year overall survival and event-free-survival (EFS) rates were 44% and 30%, respectively. All patients given TCF achieved neutrophil and platelet recovery, and the use of TCF was associated with superior EFS in the RIC population (44% versus 0%, P=.001). Patients with transformation to AML had similar outcomes to patients with less advanced stages. In conclusion, despite graft failure remaining a major concern, the role of UCBT in the management of MF, especially using RIC TCF-based regimens, deserves further investigation to improve results.
KW - Myelofibrosis
KW - Umbilical cord blood transplantation
U2 - 10.1016/j.bbmt.2014.06.011
DO - 10.1016/j.bbmt.2014.06.011
M3 - Article
C2 - 24946719
SN - 1523-6536
VL - 20
SP - 1841
EP - 1846
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 11
ER -