TY - JOUR
T1 - Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients
AU - Comabella, M.
AU - Rentzsch, K.
AU - Río, J.
AU - Bustamante, M. F.
AU - Borowski, K.
AU - Stoecker, W.
AU - Montalban, X.
N1 - Funding Information:
The authors thank the “Red Española de Esclerosis Múltiple (REEM)” sponsored by the “Fondo de Investigación Sanitaria” (FIS), Ministry of Science and Innovation , Spain, and the “Ajuts per donar Suport als Grups de Recerca de Catalunya,” sponsored by the “Agència de Gestió d'Ajuts Universitaris i de Recerca” (AGAUR), Generalitat de Catalunya , Spain.
PY - 2013/2/15
Y1 - 2013/2/15
N2 - Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12. months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.
AB - Type I interferons (IFNs) are known to enhance humoral immunity. Here, we investigated the prevalence and titer of anti-nuclear and anti-neuronal IgG autoantibodies in 71 relapsing-remitting MS patients classified based on their clinical response to IFNβ in paired sera obtained at baseline and after 12. months of treatment. All samples were negative for antibodies against cytoplasmic rods/rings, synaptic proteins and paraneoplastic antibodies. Regarding anti-nuclear, anti-filament and anti-myelin antibodies, pre- and post-treatment prevalence and titers did not differ significantly between IFNβ responders and non-responders. Thus, pattern of anti-nuclear and anti-neuronal autoantibodies does not predict the response to IFNβ in MS patients.
KW - Humoral immunity, autoantibodies
KW - Interferon-beta
KW - Multiple sclerosis
KW - Response to treatment
UR - http://www.scopus.com/inward/record.url?scp=84872651094&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2012.10.016
DO - 10.1016/j.jneuroim.2012.10.016
M3 - Article
C2 - 23182615
AN - SCOPUS:84872651094
SN - 0165-5728
VL - 255
SP - 102
EP - 104
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -