Treatment failure in osteoporosis

A. Diez-Perez; J. D. Adachi; D. Agnusdei; J. P. Bilezikian; J. E. Compston; S. R. Cummings; R. Eastell; E. F. Eriksen; J. Gonzalez-Macias; U. A. Liberman; D. A. Wahl; E. Seeman; J. A. Kanis; C. Cooper

doi:10.1007/s00198-012-2093-8

Treatment failure in osteoporosis

A. Diez-Perez, J. D. Adachi, D. Agnusdei, J. P. Bilezikian, J. E. Compston, S. R. Cummings, R. Eastell, E. F. Eriksen, J. Gonzalez-Macias, U. A. Liberman, D. A. Wahl, E. Seeman, J. A. Kanis, C. Cooper

Departament de Medicina

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Summary: Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided. Introduction: This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture. Methods: A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making. Results: In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by antiresorptive therapy and where bone mineral density continues to decrease. Conclusion: The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue. © International Osteoporosis Foundation and National Osteoporosis Foundation 2012.

Idioma original	Anglès
Pàgines (de-a)	2769-2774
Revista	Osteoporosis International
Volum	23
Número	12
DOIs	https://doi.org/10.1007/s00198-012-2093-8
Estat de la publicació	Publicada - 1 de des. 2012

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10.1007/s00198-012-2093-8

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title = "Treatment failure in osteoporosis",

abstract = "Summary: Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided. Introduction: This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture. Methods: A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making. Results: In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by antiresorptive therapy and where bone mineral density continues to decrease. Conclusion: The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue. {\textcopyright} International Osteoporosis Foundation and National Osteoporosis Foundation 2012.",

keywords = "Bone mineral density, Fractures, Markers of bone turnover, Osteoporosis, Treatment",

author = "A. Diez-Perez and Adachi, {J. D.} and D. Agnusdei and Bilezikian, {J. P.} and Compston, {J. E.} and Cummings, {S. R.} and R. Eastell and Eriksen, {E. F.} and J. Gonzalez-Macias and Liberman, {U. A.} and Wahl, {D. A.} and E. Seeman and Kanis, {J. A.} and C. Cooper",

year = "2012",

month = dec,

day = "1",

doi = "10.1007/s00198-012-2093-8",

language = "English",

volume = "23",

pages = "2769--2774",

journal = "Osteoporosis International",

issn = "0937-941X",

publisher = "Springer London",

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TY - JOUR

T1 - Treatment failure in osteoporosis

AU - Diez-Perez, A.

AU - Adachi, J. D.

AU - Agnusdei, D.

AU - Bilezikian, J. P.

AU - Compston, J. E.

AU - Cummings, S. R.

AU - Eastell, R.

AU - Eriksen, E. F.

AU - Gonzalez-Macias, J.

AU - Liberman, U. A.

AU - Wahl, D. A.

AU - Seeman, E.

AU - Kanis, J. A.

AU - Cooper, C.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Summary: Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided. Introduction: This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture. Methods: A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making. Results: In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by antiresorptive therapy and where bone mineral density continues to decrease. Conclusion: The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue. © International Osteoporosis Foundation and National Osteoporosis Foundation 2012.

AB - Summary: Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided. Introduction: This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture. Methods: A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making. Results: In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by antiresorptive therapy and where bone mineral density continues to decrease. Conclusion: The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue. © International Osteoporosis Foundation and National Osteoporosis Foundation 2012.

KW - Bone mineral density

KW - Fractures

KW - Markers of bone turnover

KW - Osteoporosis

KW - Treatment

U2 - 10.1007/s00198-012-2093-8

DO - 10.1007/s00198-012-2093-8

M3 - Article

SN - 0937-941X

VL - 23

SP - 2769

EP - 2774

JO - Osteoporosis International

JF - Osteoporosis International

IS - 12

ER -

Treatment failure in osteoporosis

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