TY - JOUR
T1 - The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
AU - Zacarías-Fluck, Mariano F.
AU - Jauset González, Toni
AU - Martínez-Martín, Sandra
AU - Kaur, Jastrinjan
AU - Casacuberta-Serra, Sílvia
AU - Massó Vallés, Daniel
AU - Serrano del Pozo, Erika
AU - Martín-Fernández, Génesis
AU - González-Larreategui, Íñigo
AU - López-Estévez, Sergio
AU - Brown-Swigart, Lamorna
AU - Beaulieu, Marie-Eve
AU - Whitfield, Jonathan R.
AU - Madan, Babita
AU - Virshup, David M.
AU - Evan, Gerard I
AU - Soucek, Laura
PY - 2021
Y1 - 2021
N2 - Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas. The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.
AB - Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas. The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.
UR - https://www.scopus.com/pages/publications/85102323979
U2 - 10.26508/lsa.201900490
DO - 10.26508/lsa.201900490
M3 - Article
C2 - 33653688
SN - 2575-1077
VL - 4
JO - Life Science Alliance
JF - Life Science Alliance
ER -