TY - JOUR
T1 - The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders
AU - Alcolea, Daniel
AU - Clarimón, Jordi
AU - Carmona-Iragui, María
AU - Illán-Gala, Ignacio
AU - Morenas-Rodríguez, Estrella
AU - Barroeta, Isabel
AU - Ribosa-Nogué, Roser
AU - Sala, Isabel
AU - Sánchez-Saudinós, M. Belén
AU - Videla, Laura
AU - Subirana, Andrea
AU - Benejam, Bessy
AU - Valldeneu, Sílvia
AU - Fernández, Susana
AU - Estellés, Teresa
AU - Altuna, Miren
AU - Santos-Santos, Miguel
AU - García-Losada, Lídia
AU - Bejanin, Alexandre
AU - Pegueroles, Jordi
AU - Montal, Víctor
AU - Vilaplana, Eduard
AU - Belbin, Olivia
AU - Dols-Icardo, Oriol
AU - Sirisi, Sònia
AU - Querol-Vilaseca, Marta
AU - Cervera-Carles, Laura
AU - Muñoz, Laia
AU - Núñez, Raúl
AU - Torres, Soraya
AU - Camacho, M. Valle
AU - Carrió, Ignasi
AU - Giménez, Sandra
AU - Delaby, Constance
AU - Rojas-Garcia, Ricard
AU - Turon-Sans, Janina
AU - Pagonabarraga, Javier
AU - Jiménez, Amanda
AU - Blesa, Rafael
AU - Fortea, Juan
AU - Lleó, Alberto
PY - 2019/1/1
Y1 - 2019/1/1
N2 - © 2019 The Authors Introduction: The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods: Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video-polysomnogram, 18F-fluorodeoxyglucose PET, amyloid PET, Tau PET). Participants are followed annually for a minimum of 4 years, with repeated cerebrospinal fluid collection and imaging studies performed every other year, and brain donation is encouraged. Results: The integration of clinical, neuropsychological, genetic, biochemical, imaging, and neuropathological information and the harmonization of protocols under the same umbrella allows the discovery and validation of key biomarkers across several neurodegenerative diseases. Discussion: We describe our particular 10-year experience and how different research projects were unified under an umbrella biomarker program, which might be of help to other research teams pursuing similar approaches.
AB - © 2019 The Authors Introduction: The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods: Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video-polysomnogram, 18F-fluorodeoxyglucose PET, amyloid PET, Tau PET). Participants are followed annually for a minimum of 4 years, with repeated cerebrospinal fluid collection and imaging studies performed every other year, and brain donation is encouraged. Results: The integration of clinical, neuropsychological, genetic, biochemical, imaging, and neuropathological information and the harmonization of protocols under the same umbrella allows the discovery and validation of key biomarkers across several neurodegenerative diseases. Discussion: We describe our particular 10-year experience and how different research projects were unified under an umbrella biomarker program, which might be of help to other research teams pursuing similar approaches.
KW - Alzheimer's disease
KW - Biomarkers
KW - Dementia with Lewy bodies
KW - Frontontemporal dementia
KW - Neurodegeneration
KW - Neuroimaging
UR - http://www.mendeley.com/research/sant-pau-initiative-neurodegeneration-spin-cohort-data-set-biomarker-discovery-validation-neurodegen
U2 - 10.1016/j.trci.2019.09.005
DO - 10.1016/j.trci.2019.09.005
M3 - Article
C2 - 31650016
SN - 2352-8737
VL - 5
SP - 597
EP - 609
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
ER -