TY - JOUR
T1 - The role of the cerebellum in multiple sclerosis—150 years after Charcot
AU - Parmar, Katrin
AU - Stadelmann, Christine
AU - Rocca, Maria A.
AU - Langdon, Dawn
AU - D'Angelo, Egidio
AU - D'Souza, Marcus
AU - Burggraaff, Jessica
AU - Wegner, Christiane
AU - Sastre-Garriga, Jaume
AU - Barrantes-Freer, Alonso
AU - Dorn, Jonas
AU - Uitdehaag, Bernard M.J.
AU - Montalban, Xavier
AU - Wuerfel, Jens
AU - Enzinger, Christian
AU - Rovira, Alex
AU - Tintore, Mar
AU - Filippi, Massimo
AU - Kappos, Ludwig
AU - Sprenger, Till
N1 - Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright: © 2018 Elsevier Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.
AB - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.
KW - Atrophy
KW - Cerebellum
KW - Cognition
KW - Depth-sensing computer vision
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Neurodegeneration
UR - https://www.scopus.com/pages/publications/85042865988
U2 - 10.1016/j.neubiorev.2018.02.012
DO - 10.1016/j.neubiorev.2018.02.012
M3 - Review article
C2 - 29477616
AN - SCOPUS:85042865988
SN - 0149-7634
VL - 89
SP - 85
EP - 98
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -