TY - JOUR
T1 - The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer
AU - Gasull, Magda
AU - Porta, Miquel
AU - Pumarega, José
AU - Vioque, Jesús
AU - de Basea, Magda Bosch
AU - Puigdomènech, Elisa
AU - Morales, Eva
AU - Grimalt, Joan O.
AU - Malats, Núria
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Background: In exocrine pancreatic cancer (EPC) mechanistic relationships may exist among some organochlorine compounds (OCs) and mutations in the K-ras oncogene, as well as among the latter and dietary factors. Objective: To analyze (1) the relationship between food intake and serum concentrations of OCs in EPC patients and (2) the relative influence of food and OCs on the frequency of K-ras mutations in EPC. Patients and methods: Incident cases of EPC were prospectively identified, and interviewed face-to-face during hospital admission (N=135 patients with data on OCs and diet, and N=97 with additional information on K-ras status). OCs were measured by high-resolution gas chromatography with electron-capture detection. Results: Consumption of milk and other dairy products was positively associated with concentrations of p,p′-DDT, PCB 138 and PCB 153 (log-transformed βs=0.652, 0.588 and 0.317, respectively; all p<0.05). When adjusted by OCs, dairy products were no longer associated with K-ras. By contrast, after adjusting by consumption of dairy products, patients with the highest concentrations of p,p′-DDT and some PCBs remained more likely to have a K-ras-mutated EPC than patients with lower concentrations (OR for upper tertile of PCB 138=5.5, 95% CI: 1.3-23.4). Conclusions: Dairy products were a source of OCs. The association between dairy products and K-ras mutations was not independent of OCs. By contrast, the association between OCs and K-ras was not confounded by dairy products. OCs may be more likely to contribute to the occurrence of K-ras mutations than nutrients contained in dairy products. © 2010 Elsevier Ltd.
AB - Background: In exocrine pancreatic cancer (EPC) mechanistic relationships may exist among some organochlorine compounds (OCs) and mutations in the K-ras oncogene, as well as among the latter and dietary factors. Objective: To analyze (1) the relationship between food intake and serum concentrations of OCs in EPC patients and (2) the relative influence of food and OCs on the frequency of K-ras mutations in EPC. Patients and methods: Incident cases of EPC were prospectively identified, and interviewed face-to-face during hospital admission (N=135 patients with data on OCs and diet, and N=97 with additional information on K-ras status). OCs were measured by high-resolution gas chromatography with electron-capture detection. Results: Consumption of milk and other dairy products was positively associated with concentrations of p,p′-DDT, PCB 138 and PCB 153 (log-transformed βs=0.652, 0.588 and 0.317, respectively; all p<0.05). When adjusted by OCs, dairy products were no longer associated with K-ras. By contrast, after adjusting by consumption of dairy products, patients with the highest concentrations of p,p′-DDT and some PCBs remained more likely to have a K-ras-mutated EPC than patients with lower concentrations (OR for upper tertile of PCB 138=5.5, 95% CI: 1.3-23.4). Conclusions: Dairy products were a source of OCs. The association between dairy products and K-ras mutations was not independent of OCs. By contrast, the association between OCs and K-ras was not confounded by dairy products. OCs may be more likely to contribute to the occurrence of K-ras mutations than nutrients contained in dairy products. © 2010 Elsevier Ltd.
KW - Dairy products
KW - Exocrine pancreatic cancer
KW - Milk
KW - Organochlorine compounds
KW - Persistent organic pollutants (POPs)
KW - Ras genes
U2 - 10.1016/j.chemosphere.2010.03.011
DO - 10.1016/j.chemosphere.2010.03.011
M3 - Article
SN - 0045-6535
VL - 79
SP - 686
EP - 697
JO - Chemosphere
JF - Chemosphere
IS - 7
ER -