TY - JOUR
T1 - The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients
AU - Ribera, Jordi
AU - Granada, Isabel
AU - Morgades, Mireia
AU - Vives, Susana
AU - Genescà, Eulàlia
AU - González, Celia
AU - Nomdedeu, Josep
AU - Escoda, Lourdes
AU - Montesinos, Pau
AU - Mercadal, Santiago
AU - Coll, Rosa
AU - González-Campos, José
AU - Abella, Eugenia
AU - Barba, Pere
AU - Bermúdez, Arancha
AU - Gil, Cristina
AU - Tormo, Mar
AU - Pedreño, María
AU - Martínez-Carballeira, Daniel
AU - Hernández-Rivas, Jesús María
AU - Orfao, Alberto
AU - Martínez-López, Joaquín
AU - Esteve, Jordi
AU - Bravo, Pilar
AU - Garcia-Guiñon, Antoni
AU - Debén, Guillermo
AU - Moraleda, José M.
AU - Queizán, José A.
AU - Ortín, Xavier
AU - Moreno, María J.
AU - Feliu, Evarist
AU - Solé, Francesc
AU - Ribera, Josep M.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - © 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
AB - © 2019 British Society for Haematology and John Wiley & Sons Ltd. The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
KW - acute lymphoblastic leukaemia
KW - adults
KW - age
KW - hypodiploidy
KW - prognosis
UR - http://www.mendeley.com/research/poor-prognosis-low-hypodiploidy-adults-bcell-precursor-acute-lymphoblastic-leukaemia-restricted-olde
UR - https://www.scopus.com/pages/publications/85063447567
U2 - 10.1111/bjh.15887
DO - 10.1111/bjh.15887
M3 - Article
C2 - 30916384
SN - 0007-1048
VL - 186
SP - 263
EP - 268
JO - British Journal of Haematology
JF - British Journal of Haematology
ER -