The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli

Daniel Porta-Casteràs; Marta Cano; Trevor Steward; Raül Andero; Narcís Cardoner

doi:10.1016/j.ynstr.2022.100448

The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli

Daniel Porta-Casteràs, Marta Cano^*, Trevor Steward, Raül Andero, Narcís Cardoner

^*Autor corresponent d’aquest treball

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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Resum

Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor gene polymorphism has been postulated as a potential sex-specific diagnostic biomarker of trauma-related disorders. However, no research to date has evaluated whether the PACAPergic system may act as a vulnerability/resilience neuromechanism to trauma-induced psychopathology in healthy participants without heightened risk to experience traumatic events. Methods: Here, we compared the amygdala and hippocampus response to fearful faces in participants with at-risk genotype versus non-risk participants from the Human Connectome Project (n = 991; 53.4% female). Results: Increased hippocampal response to fearful faces in the female risk group emerged in sex by genetic risk interaction. Conclusions: Our findings revealed the first sex-specific neurogenetic vulnerability factor to trauma-related disorders, and emphasize the importance of prevention-based strategies to ameliorate neuropsychiatric pathophysiology.

Idioma original	Anglès
Número d’article	100448
Pàgines (de-a)	1-7
Nombre de pàgines	7
Revista	Neurobiology of Stress
Volum	18
DOIs	https://doi.org/10.1016/j.ynstr.2022.100448
Estat de la publicació	Publicada - 1 de maig 2022

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10.1016/j.ynstr.2022.100448Llicència: Creative Commons Reconeixement No Comercial - Sense Obra Derivada

https://ddd.uab.cat/record/283297

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1 Actiu
3 Acabat

DIFERENCIAS DE SEXO EN LA MEMORIA DE MIEDO
Andero Gali, R. (PI), Perez Caballero, L. (Investigador/a), Florido Torres, A. L. (Col.laborador/a), Marin Blasco, I. J. (Col.laborador/a), Velasco Garcia, E. R. (Col.laborador/a), Acharya, N. (Col.laborador/a), Rodriguez Romero, L. (Col.laborador/a), Fabregat Nabás, J. (Col.laborador/a), Vanzo , G. (Col.laborador/a) & Torrent Bonilla, M. (Col.laborador/a)
1/09/21 → 31/08/25
Projecte: Projectes i Ajuts a la Recerca
BioStress: Translational biomarkers of traumatic stress
Perez Caballero, L. (Investigador/a), Molina Molina, P. (Investigador/a), Florido Torres, A. L. (Investigador/a), Velasco Garcia, E. R. (Investigador/a) & Andero Gali, R. (PI)
Instituto de Salud Carlos III (ISCIII)
1/01/20 → 31/12/23
Projecte: Projecte Internacional de Recerca
Microcircuitos y macrocircuitos de la via tac2 en aprendizaje del miedo
Andero Gali, R. (PI), Florido Torres, A. L. (Col.laborador/a) & Velasco Garcia, E. R. (Col.laborador/a)
Ministerio de Economía y Competitividad (MINECO)
30/12/16 → 29/12/20
Projecte: Projectes i Ajuts a la Recerca

Com citar-ho

@article{4a511d2df3a2418c92c0a083b3df5da9,

title = "The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli",

abstract = "Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor gene polymorphism has been postulated as a potential sex-specific diagnostic biomarker of trauma-related disorders. However, no research to date has evaluated whether the PACAPergic system may act as a vulnerability/resilience neuromechanism to trauma-induced psychopathology in healthy participants without heightened risk to experience traumatic events. Methods: Here, we compared the amygdala and hippocampus response to fearful faces in participants with at-risk genotype versus non-risk participants from the Human Connectome Project (n = 991; 53.4% female). Results: Increased hippocampal response to fearful faces in the female risk group emerged in sex by genetic risk interaction. Conclusions: Our findings revealed the first sex-specific neurogenetic vulnerability factor to trauma-related disorders, and emphasize the importance of prevention-based strategies to ameliorate neuropsychiatric pathophysiology.",

keywords = "fMRI, Hippocampus, PACAP, PTSD, Threat, Women",

author = "Daniel Porta-Caster{\`a}s and Marta Cano and Trevor Steward and Ra{\"u}l Andero and Narc{\'i}s Cardoner",

note = "Funding information: Instituto de Salud Carlos III PFIS grant FI19/00251 (DPC). Instituto de Salud Carlos III Sara Borrell grant CD20/00189 (MC). National Health and Medical Research Council/Medical Research Future Fund Investigator grant MRF1193736 (TS). Brain & Behavior Research Foundation Young Investigator Grant (TS). Brain & Behavior Research Foundation Young Investigator Grant #22434 (RA). University of Melbourne McKenzie Fellowship (TS). Ministerio de Econom{\'i}a y Competitividad, Ram{\'o}n y Cajal program RYC2014-15784 (RA). Ministerio de Econom{\'i}a y Competitividad, RETOS-MICINN SAF2016-76565-R (RA). Ministerio de Econom{\'i}a y Competitividad, RETOS-MICINN, PID2020-112705RB-I00 (RA). Fundaci{\'o}n Alicia Koplowitz (RA). Network of European Funding for Neuroscience Research through the European Commission, ERA-NET Neuron JTC 2019 ISCIII AC19/00077 (RA). Network of European Funding for Neuroscience Research through the European Commission, ERA-NET Neuron JTC 2019 ISCIII AC19/00088 (NC). Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = may,

day = "1",

doi = "10.1016/j.ynstr.2022.100448",

language = "English",

volume = "18",

pages = "1--7",

journal = "Neurobiology of Stress",

issn = "2352-2895",

publisher = "Elsevier BV",

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TY - JOUR

T1 - The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli

AU - Porta-Casteràs, Daniel

AU - Cano, Marta

AU - Steward, Trevor

AU - Andero, Raül

AU - Cardoner, Narcís

N1 - Funding information: Instituto de Salud Carlos III PFIS grant FI19/00251 (DPC). Instituto de Salud Carlos III Sara Borrell grant CD20/00189 (MC). National Health and Medical Research Council/Medical Research Future Fund Investigator grant MRF1193736 (TS). Brain & Behavior Research Foundation Young Investigator Grant (TS). Brain & Behavior Research Foundation Young Investigator Grant #22434 (RA). University of Melbourne McKenzie Fellowship (TS). Ministerio de Economía y Competitividad, Ramón y Cajal program RYC2014-15784 (RA). Ministerio de Economía y Competitividad, RETOS-MICINN SAF2016-76565-R (RA). Ministerio de Economía y Competitividad, RETOS-MICINN, PID2020-112705RB-I00 (RA). Fundación Alicia Koplowitz (RA). Network of European Funding for Neuroscience Research through the European Commission, ERA-NET Neuron JTC 2019 ISCIII AC19/00077 (RA). Network of European Funding for Neuroscience Research through the European Commission, ERA-NET Neuron JTC 2019 ISCIII AC19/00088 (NC). Publisher Copyright: © 2022 The Authors

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor gene polymorphism has been postulated as a potential sex-specific diagnostic biomarker of trauma-related disorders. However, no research to date has evaluated whether the PACAPergic system may act as a vulnerability/resilience neuromechanism to trauma-induced psychopathology in healthy participants without heightened risk to experience traumatic events. Methods: Here, we compared the amygdala and hippocampus response to fearful faces in participants with at-risk genotype versus non-risk participants from the Human Connectome Project (n = 991; 53.4% female). Results: Increased hippocampal response to fearful faces in the female risk group emerged in sex by genetic risk interaction. Conclusions: Our findings revealed the first sex-specific neurogenetic vulnerability factor to trauma-related disorders, and emphasize the importance of prevention-based strategies to ameliorate neuropsychiatric pathophysiology.

AB - Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor gene polymorphism has been postulated as a potential sex-specific diagnostic biomarker of trauma-related disorders. However, no research to date has evaluated whether the PACAPergic system may act as a vulnerability/resilience neuromechanism to trauma-induced psychopathology in healthy participants without heightened risk to experience traumatic events. Methods: Here, we compared the amygdala and hippocampus response to fearful faces in participants with at-risk genotype versus non-risk participants from the Human Connectome Project (n = 991; 53.4% female). Results: Increased hippocampal response to fearful faces in the female risk group emerged in sex by genetic risk interaction. Conclusions: Our findings revealed the first sex-specific neurogenetic vulnerability factor to trauma-related disorders, and emphasize the importance of prevention-based strategies to ameliorate neuropsychiatric pathophysiology.

KW - fMRI

KW - Hippocampus

KW - PACAP

KW - PTSD

KW - Threat

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=85129568525&partnerID=8YFLogxK

U2 - 10.1016/j.ynstr.2022.100448

DO - 10.1016/j.ynstr.2022.100448

M3 - Article

C2 - 35685680

AN - SCOPUS:85129568525

SN - 2352-2895

VL - 18

SP - 1

EP - 7

JO - Neurobiology of Stress

JF - Neurobiology of Stress

M1 - 100448

ER -

The pituitary adenylate cyclase-activating polypeptide system as a sex-specific modulator of hippocampal response to threat stimuli

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DIFERENCIAS DE SEXO EN LA MEMORIA DE MIEDO

BioStress: Translational biomarkers of traumatic stress

Microcircuitos y macrocircuitos de la via tac2 en aprendizaje del miedo

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